A5035335028- Hormonal Regulation and Hypertension
- Mycotoxins in Agriculture and Food
- Ion Transport and Channel Regulation
- Carcinogens and Genotoxicity Assessment
- Drug Transport and Resistance Mechanisms
- Biomedical and Chemical Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Estrogen and related hormone effects
- COVID-19 and Mental Health
- Cancer, Hypoxia, and Metabolism
- Long-Term Effects of COVID-19
- Chronic Kidney Disease and Diabetes
- Receptor Mechanisms and Signaling
- Eicosanoids and Hypertension Pharmacology
- COVID-19 Clinical Research Studies
- Selenium in Biological Systems
- Physics and Engineering Research Articles
- Metabolism and Genetic Disorders
- Nitric Oxide and Endothelin Effects
- Plant Disease Resistance and Genetics
- Acute Kidney Injury Research
- Medical and Health Sciences Research
- Ion channel regulation and function
- Bacillus and Francisella bacterial research
- Liver Disease Diagnosis and Treatment
Martin Luther University Halle-Wittenberg
2016-2025
Luther University
2021-2022
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2017
University Hospital Münster
2017
University of Veterinary Medicine Hannover, Foundation
2017
Freie Universität Berlin
2017
University Hospital in Halle
2015
University of Münster
2004-2012
Max Delbrück Center
2011-2012
Medical University of Vienna
2011-2012
Abstract Nearly all mass gathering events worldwide were banned at the beginning of COVID-19 pandemic, as they suspected presenting a considerable risk for transmission SARS-CoV-2. We investigated transmitting SARS-CoV-2 by droplets and aerosols during an experimental indoor event under three different hygiene practices, used data in simulation study to estimate resulting burden disease conditions controlled epidemics. Our results show that mean number measured direct contacts per visitor...
Abstract The steroid hormone aldosterone is important for salt and water homeostasis as well pathological tissue modifications in the cardiovascular system kidney. mechanisms of action include a classical genomic pathway, but physiological relevant nongenotropic effects have also been described. Unlike estrogens or progesterone, these are not understood, although pharmacological studies suggest role mineralocorticoid receptor (MR). Here we investigated whether MR contributes to effects....
Tumor micromilieu often shows pronounced acidosis forcing cells to adapt their phenotype towards enhanced tumorigenesis induced by altered cellular signalling and transcriptional regulation. In the presents study mechanisms potential consequences of crosstalk between extra- intracellular pH (pHe, pHi) mitogen-activated-protein-kinases (ERK1/2, p38) was analyzed. Data were obtained mainly in AT1 R-3327 prostate carcinoma cells, but principle importance confirmed 5 other cell types....
Post-acute sequelae of COVID-19 (PASC) are long-term consequences SARS-CoV-2 infection that can substantially impair the quality life. Underlying mechanisms ranging from persistent viruses to innate and adaptive immune dysregulation have been discussed. Here, we profiled plasma 181 individuals cohort study for digital health research in Germany (DigiHero), including after mild moderate with or without PASC uninfected controls. We focused on soluble factors related monocyte/macrophage biology...
The expression and activity of P-glycoprotein (pGP) play a role in the multidrug resistance tumors. Because solid-growing tumors often show pronounced hypoxia or extracellular acidosis, this study attempted to analyze impact an acidic environment on pGP cytotoxicity chemotherapeutic agents. For this, prostate carcinoma cells were exposed (pH 6.6) for up 24 hours. was more than doubled after 3 6 hours incubation medium, whereas cellular remained constant, indicating that increased transport...
There is increasing evidence for an additional acute, nongenomic action of the mineralocorticoid hormone aldosterone on renal epithelial cells, leading to a two-step model electrolyte excretion. We investigated acute effect intracellular free Ca2+ and pH in aldosterone-sensitive Madin-Darby canine kidney cell clone. Within seconds application aldosterone, but not glucocorticoid hydrocortisone, there was 3-fold sustained increase at half-maximal concentration 10(-10) mol/liter. Omission...
Background:Asymmetrical NG, NG-dimethylarginine (ADMA) is associated with impaired endothelium-dependent vasodilation in humans.
Arterial aging is a predominant risk factor for the onset of cardiovascular diseases, such as hypertension, myocardial infarction, or stroke. Aging associated with intravascular renin-angiotensin system activation, increased vascular stiffness, intima-media thickening, and proinflammatory phenotype. Little known about influence aldosterone on arterial aging. Hence, we hypothesized that mineralocorticoid receptor (MR) activation might contribute to possibly accelerate process. We demonstrate...
Aldosterone triggers the stiff endothelial cell syndrome (SECS), characterized by an up-regulation of epithelial sodium channels (ENaCs) and mechanical stiffening cortex accompanied dysfunction. In vivo, aldosterone antagonism exerts sustained protection on cardiovascular system. To illuminate molecular mechanisms this time-dependent effect, a study cells in vitro ex vivo was designed to investigate SECS over time. Endothelia (from human umbilical veins, bovine aortae, explants arteries)...
Background In the connected world, although societies are not directly involved in a military conflict, they exposed to media reports of violence. Aims We assessed effects such exposures on mental health Germany during conflict Ukraine. Method used German population-based cohort for digital research, DigiHero, launching survey eighth day Russo-Ukrainian war. Of 27 509 participants from general population, 19 444 (70.7%) responded within 17 days. measured and fear impact war compared with...
Ochratoxin A (OTA) is a ubiquitous fungal metabolite with nephritogenic, carcinogenic, and teratogenic action. Epidemiological studies indicate that OTA may be involved in the pathogenesis of different forms human nephropathies. Previously we have shown activates extracellular signal-regulated kinases 1 2, members mitogen-activated protein (MAPK) family, C7-clone but not C11-clone renal epithelial Madin-Darby canine kidney (MDCK) cells. Here show nanomolar concentrations lead to activation...
1 Receptor-mediated endocytosis is an important mechanism for transport of macromolecules and regulation cell-surface receptor expression. In renal proximal tubules, receptor-mediated mediates the reabsorption filtered albumin. Acidification endocytic compartments essential because it interferes with ligand-receptor dissociation, vesicle trafficking, fusion events coat formation. 2 Here we show that activity Na+-H+ exchanger isoform 3 (NHE3) proper albumin endosomal pH homeostasis in a...
The steroid hormone aldosterone plays an important role during pathological tissue modifications, similar to cardiovascular or renal fibrosis. underlying mechanisms for the actions are not understood. Interaction of with epidermal growth factor (EGF) receptor is attractive hypothesis explain remodeling elicited by aldosterone, because (i) mineralocorticoids can sensitize cells EGF, (ii) mineralocorticoid (MR)-antagonists reduce EGFR-mRNA expression, (iii) EGFR itself supports development...