A5003009662- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Mycotoxins in Agriculture and Food
- Acute Kidney Injury Research
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects and Toxicity Studies
- Hepatitis C virus research
- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Chronic Myeloid Leukemia Treatments
- Insect and Pesticide Research
- Carcinogens and Genotoxicity Assessment
- Poisoning and overdose treatments
- Pharmacology and Obesity Treatment
- Hormonal Regulation and Hypertension
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Complementary and Alternative Medicine Studies
- HIV-related health complications and treatments
- Selenium in Biological Systems
- Abdominal Trauma and Injuries
- Biomedical Research and Pathophysiology
Klinik Schongau
2022-2023
LMU Klinikum
2007-2021
Ludwig-Maximilians-Universität München
2007-2021
München Klinik
2011-2020
University of Würzburg
1999-2007
Abstract The steroid hormone aldosterone is important for salt and water homeostasis as well pathological tissue modifications in the cardiovascular system kidney. mechanisms of action include a classical genomic pathway, but physiological relevant nongenotropic effects have also been described. Unlike estrogens or progesterone, these are not understood, although pharmacological studies suggest role mineralocorticoid receptor (MR). Here we investigated whether MR contributes to effects....
The development of acute‐on‐chronic liver failure (ACLF) in patients with cirrhosis is associated high mortality rates. Renal the most significant organ dysfunction that occurs ACLF. So far there are no biomarkers predicting We investigated whether cystatin C (CysC) and neutrophil gelatinase‐associated lipocalin (NGAL) can predict renal (RD), hepatorenal syndrome (HRS), ACLF, mortality. determined plasma levels CysC NGAL 429 hospitalized for acute decompensation EASL‐CLIF Acute‐on‐Chronic...
<h3>Background</h3> Idiosyncratic drug-induced liver injury (iDILI) is a frequent cause of acute and serious problem in late stage drug-development. Its diagnosis one the most challenging hepatology, since it done by exclusion relies on expert opinion. Until now no reliable vitro test exists to support iDILI. In some instances impossible determine causative drug polymedicated patients. <h3>Aim</h3> To investigate if monocyte-derived hepatocyte-like (MH) cells might be tool supporting...
Abstract Background Drug‐induced liver injury (DILI) and idiopathic autoimmune hepatitis (AIH) are competing diagnoses in patients with acute (ALI) drug intake. In absence of unequivocal markers, scores like RUCAM AIH used to distinguish both entities. However, some cases the diagnosis remains ambiguous. Our aim was identify a simple parameter discriminate DILI shortly after starting corticosteroid treatment. Methods For current analysis, 44 ALI who took at least one received corticosteroids...
The potential of metamizole to cause drug-induced liver injury (DILI) has received increasing attention. We investigated the distinguishing features a case series comprising 32 patients with suspected metamizole-induced DILI. For current analysis, 238 DILI included in our prospective study on drugs potentially causing were included. Diagnosis was based expert opinion and RUCAM (Roussel Uclaf Causality Assessment Method) score supported by an vitro test using monocyte-derived hepatocyte-like...
Idiosyncratic drug-induced liver injury (iDILI) is a major cause of acute failure resulting in transplantation or death. Prediction and diagnosis iDILI remain great challenge, as current models provide unsatisfying results terms sensitivity, specificity prognostic value. The absence appropriate tools for detection also impairs the development reliable biomarkers. Here, we report on new method identification drug-specific We combined advantages monocyte-derived hepatocyte-like (MH) cells,...
<b><i>Introduction:</i></b> A proportion of patients with drug-induced liver injury (DILI) present autoantibodies, which has led to the current concept autoimmune-like DILI. However, no standardized definition exists and clinical relevance not been studied in detail yet. <b><i>Methods:</i></b> 143 DILI enrolled a prospective study were analyzed. diagnosis was based on monocyte-derived hepatocyte-like cell test supported by Roussel Uclaf...
Drug-induced liver injury (DILI) is a major cause for acute failure and regulatory actions on novel drugs. Individual patient characteristics are the main determinant of idiosyncratic DILI, making DILI (iDILI) one most challenging diagnoses in hepatology. drug-drug interactions might play role iDILI. However, current approaches to iDILI diagnosis focused single drugs as causative agents. For present analysis, 48 patients with who took 2 were diagnosed investigated. A vitro test was employed...
1Department of Medicine IILiver Centre Munich, University Hospital, LMU MunichMunichGermany 2MetaHeps GmbHMartinsriedGermany * Address Correspondence and Reprint Requests to: Andreas Benesic, M.D. Department II, Liver Munich Marchioninistr. 15 81377 Germany E‐mail: [email protected] Tel.: +49 (0)89 4400 73130
Background/Aims: Chronic renal proximal tubule dysfunction after therapy with the antineoplastic agent ifosfamide (IFO) is often attributed to metabolite chloroacetaldehyde (CAA). IFO-nephropathy reported result in tubulointerstitial fibrosis and inflammation. Methods: To elucidate possible effects of CAA on extracellular matrix homeostasis, we investigated action markers (ECM) homeostasis human cells (RPTEC) by use direct ELISA for collagens gelatin zymography. Results: An increase type III...
Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO. Depletion sulfhydryl (SH) groups has been reported from cell culture, animal clinical studies. In this work effect CAA on human proximal tubule cells in primary culture (hRPTEC) was investigated. Toxicity determined by protein content, number, LDH release, trypan blue exclusion assay caspase-3 activity. Free thiols were measured...
Drug-induced liver injury (DILI) is the most common cause of acute failure and accounts for majority regulatory actions on drugs. Furthermore, DILI a relevant project terminations in pharmaceutical development. The idiosyncratic form especially threat late clinical development phases postmarketing, respectively. Even occurrence only few cases or postmarketing may suffice to terminate withdraw an otherwise promising therapy. Despite advances preclinical assessment dose-dependent toxicity,...