A5103172108- Effects of Radiation Exposure
- Radiation Dose and Imaging
- Radioactive contamination and transfer
- Radioactivity and Radon Measurements
- Genomics, phytochemicals, and oxidative stress
- Thyroid Disorders and Treatments
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Genetic factors in colorectal cancer
- Mycotoxins in Agriculture and Food
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Diagnosis and Treatment of Venous Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Ion channel regulation and function
- Advanced Neuroimaging Techniques and Applications
- Adolescent and Pediatric Healthcare
- Aldose Reductase and Taurine
- Lysosomal Storage Disorders Research
- Microbial Inactivation Methods
- Selenium in Biological Systems
- PARP inhibition in cancer therapy
- Heat shock proteins research
- Electrolyte and hormonal disorders
Praxis
2023
Schwarzwald-Baar Klinikum
2022
Institut für Radiobiologie der Bundeswehr
2014-2021
Universität der Bundeswehr München
2016-2021
Bundeswehr Medical Service Academy
2016-2021
LMU Klinikum
2018-2021
Ludwig-Maximilians-Universität München
2018-2021
Universität Ulm
2015-2021
Institut de Radiobiologie Cellulaire et Moléculaire
2020
Johannes Gutenberg University Mainz
2006-2018
The radiotoxic effects of uranium are often in the focus public fears but chemical toxic reported to surpass radiation effects. As there is no isotope that not radioactive, it possible study fully independently from In order quantitate and compare radio- chemotoxicity, we determined median lethal doses due its toxicity calculated absorbed radiological resulting ingestion or inhalation corresponding amounts depending on isotopic enrichment grade. Committed effective over 50 years related...
To look for the presence and age-dependence of late structural alterations otherwise normal-appearing cerebral gray white matter after radiation chemotherapy in adult survivors acute lymphoblastic leukemia (ALL) during childhood.In a group 13 17-37 years old, who had been treated by total brain (18-24 Gy) 16-28 ago, prospective MR examinations including diffusion tensor imaging (DTI) were performed. Evaluation included volumetry, calculation mean diffusivity (MD) fractional anisotropy (FA),...
A wide spectrum of scenarios may lead to radiation incidents and the liberation radioactive material. In case a terrorist attack by "dirty bomb", there is risk mechanical thermal trauma, external irradiation, superficial contamination incorporation The first treatment priority must be given care trauma patients with life-threatening injuries, as health effects occur latency. Radionuclide will longer-lasting irradiation from inside body, associated higher stochastic (e.g., occurrence tumors)...
Purpose In a nuclear or radiological event, an early diagnostic tool is needed to distinguish the worried well from those individuals who may later develop life-threatenFing hematologic acute radiation syndrome. We examined contribution of peripheral blood's cell populations on radiation-induced gene expression (GE) changes.Materials and methods EDTA-whole-blood six healthy donors was X-irradiated with 0 4Gy T-lymphocytes, B-lymphocytes, NK-cells granulocytes were separated using...
High-grade neuroepithelial tumor of the central nervous system with BCOR alteration (HGNET-BCOR) is a rare, highly malignant tumor. At time this publication, no standard protocol exists to treat entity. In work, we tested responsiveness primary culture PhKh1 derived from tissue pediatric HGNET-BCOR patient (P1) inhibitors Sonic hedgehog pathway combined radiation. The SMO vismodegib and itraconazole had low effect on proliferation cells. However, GLI inhibitor arsenic trioxide reduced...
In the case of a terrorist attack by "dirty bomb", blast injuries, external irradiation and incorporation radioactivity are to be expected. Departing from information about radiological scenario with cesium-137 in U.S. National Scenario Planning Guide, we estimated doses absorbed. Similar calculations were performed for smaller plume size detonation subway. For conditions as described scenario, committed effective dose amounted maximum 848 mSv, even very unfavorable conditions. Red bone...
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an important cofactor in the p53-mediated DNA damage response pathway upon ionizing radiation (IR) and exerts anti-apoptotic effects also independent of p53 activation. Furthermore, hnRNP overexpressed various neoplasms including malignant melanoma (MM). Here, we investigate role radioresistance MM cells.Our results show cytoplasmic expression human surgical specimens, but not benign nevi, a quick dose- time-dependent upregulation to IR...
In the case of a nuclear power plant accident, repetitive/prolonged radioiodine release may occur. Radioiodine accumulates in thyroid and by irradiation enhances risk cancer. Large doses non-radioactive iodine protect inhibiting uptake into gland (iodine blockade). Protection is based on competition at active carrier site cellular membrane Wolff-Chaikoff effect, latter being, however, only transient (24-48 h). Perchlorate alternatively provide protection mechanism only. has, stronger...
In the case of a terrorist attack by "dirty bomb" there is risk internal contamination with radionuclides through inhalation and wounds. We studied efficacy decorporation treatment depending on initiation time duration.
Metastasis is the survival-determining factor in urothelial carcinoma (UC) of urinary bladder. The small conductance calcium-activated potassium channel 3 (SK3) enhances tumor cell invasion breast cancer and malignant melanoma. Since Edelfosine, a glycerophospholipid with antitumoral properties, effectively inhibits SK3 activity, our goal was to evaluate as potential molecular target inhibit gain an invasive phenotype UC. protein expression analyzed 208 tissue samples UC lines. Effects...
Abstract Background In radiological emergencies with radionuclide incorporation, decorporation treatment is particularly effective if started early. Treating all people potentially contaminated (“urgent treatment”) may require large antidote stockpiles. An efficacious way to reduce requirements by using radioactivity screening equipment. We analyzed the suitability of such equipment for triage purposes and determined most efficient mix units daily doses. Methods The committed doses...
Background: In the case of a nuclear or radiological incident, there is risk external and internal contamination with radionuclides in addition to irradiation. There no consensus whether decorporation treatment should be initiated right away on spec pending results dosimetry determine indication. Method: Based biokinetic models for plutonium-239, americium-241 cesium-137, efficacy using DTPA Prussian blue was simulated depending initiation time duration different invasion pathways...
Abstract Childhood radiation exposure has been associated with increased papillary thyroid carcinoma (PTC) risk. The role of anaplastic lymphoma kinase ( ALK ) gene rearrangements in radiation‐related PTC remains unclear, but STRN‐ALK fusions have recently detected PTCs from exposed persons after Chernobyl using targeted next‐generation sequencing and RNA‐seq. We investigated RET as well known driver point mutations tumours 77 radiation‐exposed patients (mean age at surgery 22.4 years) 19...
Radioactive iodine released in nuclear accidents may accumulate the thyroid and by irradiation enhances risk of cancer. Radioiodine uptake into gland can be inhibited large doses stable or perchlorate. Nutritional daily intake impact physiology, so that radiological absorbed as well blocking efficacy differ Japanese with a very rich diet compared to Caucasians. Based on established biokinetic-dosimetric models for thyroid, we derived parameters Caucasians quantitatively compare effects...
In radiological emergencies, there is a risk of radionuclide incorporation. The doses absorbed can be reduced by decorporation treatment. Antidote requirements depend on the scenario and treatment strategy ("urgent approach": immediate all patients with possible incorporation; "precautionary only after confirmation incorporation). We calculated number daily antidote for different scenarios differences in outcome both strategies.The potentially contaminated victims was varied from 1,000 to...
Radiotherapy represents a common treatment strategy for patients suffering from oral squamous cell carcinoma (OSCC). However, application of radiotherapy is immanently limited by radio-sensitivity normal tissue surrounding the tumor sites. In this study, we used human epithelial keratinocytes (NHEK) and OSCC cells (Cal-27) as models to investigate radio-modulating anti-tumor effects synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid methyl ester (CDDO-Me). Nanomolar...
In the case of an attack by a "dirty bomb" with cesium-137 there is risk internal contamination. The excretion can be enhanced Prussian Blue (PB), and thus committed effective dose reduced. We analyzed benefit costs PB decorporation treatment. simulated reduction radiological treatment after incorporation inhalation. saving life time was quantified using monetary "value statistical life" (VSL). Treatment were based on market price in Germany. Moreover we considered holding stockpiling....
Radiofrequency electromagnetic fields (RF-EMF) are a basic requirement of modern wireless communication technology. Statutory thresholds RF-EMF established to limit relevant additional heat supply in human tissue. Nevertheless, date, questions concerning nonthermal biological effects have yet be fully addressed. New versions microarrays (8 × 60K v2) provide higher resolution whole genome gene expression display adaptive processes cells after irradiation. In this ex vivo/ vitro study, we...
Ionizing radiation produces reactive oxygen species (ROS) leading to cellular DNA damage. Therefore, patients undergoing therapy or first responders in radiological accident scenarios could both benefit from the identification of specifically acting pharmacological radiomitigators. The synthetic triterpenoid bardoxolone-methyl (CDDO-Me) has previously been shown exert antioxidant, anti-inflammatory and anticancer activities several cell lines, part by enhancing damage response. In our study,...
Purpose In the case of a nuclear incident, release radioiodine must be expected. Radioiodine accumulates in thyroid and by irradiation enhances risk cancer. Large doses stable (non-radioactive) iodine may inhibit accumulation protect (‘thyroid blocking’). Protection is based on competition at active carrier site cellular membrane an additional temporary inhibition organification iodide (Wolff-Chaikoff effect). Alternatively, other agents like e.g. perchlorate that compete with for uptake...