A5012426378- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Immune Response and Inflammation
- Photodynamic Therapy Research Studies
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Liver physiology and pathology
- Inflammasome and immune disorders
- Case Reports on Hematomas
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Heme Oxygenase-1 and Carbon Monoxide
- Amino Acid Enzymes and Metabolism
- Bacillus and Francisella bacterial research
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Eosinophilic Disorders and Syndromes
- Metabolism and Genetic Disorders
- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
National Defense Medical College
2015-2024
Seiko Holdings (Japan)
2022
Nagoya University
2014-2022
RIKEN Center for Integrative Medical Sciences
2022
Osaka University
2022
National Defense Medical College Hospital
2011-2017
Tokyo University of Pharmacy and Life Sciences
2014
Jikei University School of Medicine
2014
Japan Patent Office
2014
Bipar
2007
ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into 'overproduction type' and/or 'underexcretion based solely on renal excretion, without considering an extra-renal pathway. Here we show that decreased excretion caused by ABCG2 common mechanism hyperuricemia. Clinical parameters, including urinary are examined in 644 male outpatients with Paradoxically, export significantly...
Gout based on hyperuricemia is a common disease with genetic predisposition, which causes acute arthritis. The ABCG2/BCRP gene, located in gout-susceptibility locus chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Urate transport assays demonstrated that ABCG2 high-capacity urate secretion transporter. Sequencing the gene 90 patients revealed several nonfunctional mutations, including Q126X. Quantitative trait analysis...
Abstract The hepatocyte growth factor receptor c-Met is a tyrosine kinase that plays an important role in tumor by activating mitogenic signaling pathways. goal of this study was to evaluate the biology ovarian cancer and determine its potential as therapeutic target. protein expression detected immunohistochemistry 138 advanced-stage cancers using tissue microarray annotated with disease-specific patient follow-up. Fifteen (11%) tissues had overexpression. Median survival for patients high...
L-type amino acid transporter 1 (LAT1) is a Na+-independent neutral transport agency and essential for the of large acids. LAT1 has been identified as light chain CD98 heterodimer from C6 glioma cells. also corresponds to TA1, an oncofetal antigen that expressed primarily in fetal tissues cancer We have investigated first time, expression human primary astrocytic tumor tissue 60 patients. unique because it requires additional single membrane spanning protein, heavy 4F2 cell surface (4F2hc),...
Invasive and proliferative phenotypes are fundamental components of malignant disease, yet basic questions persist about whether tumor cells can express both simultaneously and, if so, what their properties. Suitable in vitro models that allow characterization purely invasive limited because proliferation is required for cell maintenance. Here, we describe glioblastoma highly response to hepatocyte growth factor/scatter factor (HGF/SF). From this population, selected subclones were or...
Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and subtypes remains unclear. Here, we first performed GWAS clinically defined only. Methods A conducted with 945 patients 1213 controls Japanese male population, followed replication study 1048 1334 controls....
Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 major cause renal overload (ROL) hyperuricemia, but its involvement in underexcretion (RUE) most prevalent subtype, not clearly explained so far. In this study, association analysis with 644 hyperuricemia patients and 1,623 controls male Japanese revealed significantly increased risk RUE as well overall ROL according to severity impairment. caused induced even if was...
Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether dysfunction ABCG2, high-capacity urate transporter regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout cases with onset data and 1,887 controls were genotyped, ABCG2 functions are estimated by its genotype combination determined. The was 6.5 years earlier severe than normal function (P = 6.14 × 10(-3)). Patients...
Abstract Noise-induced hearing loss (NIHL) is one of the most common sensorineural deficits. Recent studies have demonstrated that pathogenesis NIHL closely related to ischemia-reperfusion injury cochlea, which caused by blood flow decrease and free radical production due excessive noise. This suggests protecting cochlea from oxidative stress an effective therapeutic approach for NIHL. NRF2 a transcriptional activator playing essential role in defense mechanism against stress. To clarify...
Ginsenoside Rh 2 (Rh ), isolated from an ethanol extract of the processed root Panax ginseng CA Meyer, inhibits growth B16 melanoma cells. This study was designed to evaluate ability inhibit human ovarian cancer cells (HRA) in vitro and nude mouse. inhibited proliferations various established cell lines a dose‐dependent manner between 10 60 μ M induced apoptosis at around IC 50 dose. When HRA were inoculated s.c. into right flank mice, all mice formed palpable tumor within 14 days. Although...
BACKGROUND: xCT is a light chain of the cystine/glutamate antiporter system xc−. Glutamate that released by xc− plays an important role in infiltration glioblastoma (GBM) cells. Furthermore, increased glutathione synthesis may protect tumor cells against oxidative stress induced radiotherapy and chemotherapy. OBJECTIVE: To investigate whether levels expression correlated with infiltrative imaging phenotypes on magnetic resonance outcomes patients GBMs. METHODS: Forty histologically confirmed...
Objective Serum uric acid (SUA) levels in humans are mainly regulated by urate transporters. Recent genome‐wide association studies suggested that common variants of the human sodium‐dependent phosphate cotransporter type 1 gene ( NPT1/SLC17A1 ) influence SUA. NPT1 has been reported to mediate transport, but its physiologic role regulating SUA remains unclear. Furthermore, findings replication relationship between and gout have inconsistent. The aims this study were investigate effect on...
Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, dysfunctional variants of ABCG2, urate exporter gene also known as BCRP, are revealed to be major cause gout/hyperuricemia. Here, we compared the influence ABCG2 dysfunction on serum uric acid (SUA) levels with other risk factors in cohort 5,005 Japanese participants. was observed 53.3% population investigated and its population-attributable percent (PAR%) for hyperuricemia 29.2%, much higher...
ATP-binding cassette transporter G2 (ABCG2), also known as breast cancer resistance protein (BCRP), is identified a high-capacity urate exporter and its dysfunction has an association with serum uric acid (SUA) levels gout/hyperuricemia risk. However, pathophysiologically important pathway(s) responsible for the ABCG2-mediated excretion were unknown. In this study, we investigated how ABCG2 affected pathways. First, revealed that mouse Abcg2 mediates transport using membrane vesicle system....
Epidemiological studies have suggested that the regular use of nonsteroidal antiinflammatory drugs, which inhibit cyclooxygenase (COX), reduces risk colon cancer. The inducible COX-2 isoform has been reported to be upregulated in colorectal carcinomas and may play a role carcinogenesis. purpose this study was investigate expression protein human gastric adenocarcinomas.COX-2 examined 23 patients with adenocarcinoma by immunoblotting immunohistochemistry.There an increase levels 19 (83%)...