Thomas Müller
A5066764071- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Renal Diseases and Glomerulopathies
- Immune Response and Inflammation
- Complement system in diseases
- Psychology, Coaching, and Therapy
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Chronic Myeloid Leukemia Treatments
- Multiple Sclerosis Research Studies
- Effects of Radiation Exposure
- vaccines and immunoinformatics approaches
- Psychiatric care and mental health services
- Respiratory and Cough-Related Research
Karolinska Institutet
2022-2025
Institute of Medical Microbiology and Hygiene
2008-2024
Technical University of Munich
2007-2024
German Center for Infection Research
2019-2024
Princess Margaret Cancer Centre
2004-2023
The University of Texas MD Anderson Cancer Center
2004-2023
Universitätsmedizin Rostock
2023
Affimed Therapeutics (Germany)
2017-2023
Indiana University – Purdue University Indianapolis
2004-2023
Svenska Örtmedicinska Institute
2023
To compare the efficacy and toxicity of pemetrexed versus docetaxel in patients with advanced non-small-cell lung cancer (NSCLC) previously treated chemotherapy.
XL184 (cabozantinib) is a potent inhibitor of MET, vascular endothelial growth factor receptor 2 (VEGFR2), and RET, with robust antiangiogenic, antitumor, anti-invasive effects in preclinical models. Early observations clinical benefit phase I study cabozantinib, which included patients medullary thyroid cancer (MTC), led to expansion an MTC-enriched cohort, the focus this article.
We sought to clarify the prognostic impact of primary tumor location in metastatic colorectal cancer (mCRC). evaluated association between and survival parameters patients with previously untreated mCRC receiving first-line chemotherapy ± bevacizumab three independent cohorts: a prospective pharmacogenetic study (PROVETTA) two randomized phase III trials, AVF2107g NO16966. Cancers proximal or distal splenic flexure were classified as right-sided left-sided, respectively. The end point was...
Abstract The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant concern (VOC) has destabilized global efforts to control impact disease 2019 (COVID-19). Recent data have suggested that B.1.1.529 can readily infect people with naturally acquired or vaccine-induced immunity, facilitated in some cases by viral escape from antibodies neutralize ancestral SARS-CoV-2. However, appears be relatively uncommon such individuals, highlighting a...
To compare the efficacy and toxicity of pemetrexed versus docetaxel in patients with advanced non-small-cell lung cancer (NSCLC) previously treated chemotherapy.
T cells are critical in mediating the early control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection. However, it remains unknown whether memory can effectively cross-recognize new SARS-CoV-2 variants with a broad array mutations, such as emergent hypermutated BA.2.86 variant. Here, we report two separate cohorts, including healthy controls and individuals chronic lymphocytic leukemia, that spike-specific CD4
Abstract Emerging evidence suggests an important role for human epidermal keratinocytes in innate immune mechanisms against bacterial and viral skin infections. The proinflammatory effect of infections can be mimicked by double-stranded RNA (dsRNA). Herein, we demonstrate that express all known dsRNA sensing receptors at a constitutive inducible level, they use several downstream signaling pathways leading to broad pattern gene expression, not only response genes under the control NF-κB, but...
Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and with various forms immunodeficiencies. Impaired vaccine-induced cell-mediated was observed many patients, particularly solid-organ transplant chronic lymphocytic leukemia patients. Notably, an inherited lack mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed...
Redirection of immune cells to efficiently eliminate tumor holds great promise. Natural killer (NK), macrophages, or T are specifically engaged with target expressing markers after infection neoplastic transformation, resulting in their activation and subsequent killing those targets. Multiple strategies redirect immunity have been developed the past two decades, but they technical hurdles cause undesirable side-effects, as exemplified by cell-based chimeric antigen receptor approaches...
Adoptive transfer of T cells expressing a transgenic cell receptor (TCR) has the potential to revolutionize immunotherapy infectious diseases and cancer. However, generation defined TCR-transgenic medicinal products with predictable in vivo function still poses major challenge limits broader more successful application this "living drug." Here, by studying 51 different TCRs, we show that conventional genetic engineering viral transduction leads variable TCR expression functionality as result...
Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in individuals with various immunodeficiencies. Given the increased antibody evasion properties of emerging subvariants, it is necessary assess whether other components adaptive generate resilient and protective responses against infection. We assessed T cell 279 individuals, covering five different immunodeficiencies healthy controls, before after booster vaccination, as well Omicron infection a subset patients....
Mucosal-associated invariant T (MAIT) cells are unconventional that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ donor–matched blood, barrier, and lymphoid tissues. population size was donor dependent with distinct tissue compartmentalization patterns adaptations: Intestinal CD103 + resident an immunoregulatory CD39 high CD27 low profile, whereas expressing NCAM1/CD56 dominated...
Abstract —Dietary ω-3 fatty acids retard coronary atherosclerosis. Previously, we demonstrated that dietary reduce platelet-derived growth factor (PDGF)-A and PDGF-B mRNA levels in unstimulated, human mononuclear cells (MNCs). In a randomized, investigator-blinded intervention trial, have now compared the effect of ingestion 7 g/d ω-3, ω-6, or ω-9 for 4 weeks versus no on PDGF-A, PDGF-B, heparin-bound epidermal (HB-EGF), monocyte chemoattractant protein-1 (MCP-1), interleukin-10 gene...
Mucosal-associated invariant T (MAIT) cells are unconventional that mediate rapid antimicrobial immune responses to antigens derived from microbial riboflavin pathway metabolites presented by the evolutionarily conserved MR1 molecules. MAIT represent a large pre-expanded cell subset in humans and involved both protective immunity inflammatory immunopathology. However, what controls functional heterogeneity of human is still largely unclear. Here, combining transcriptomic analyses, we...
Purpose To evaluate whether cisplatin-based chemotherapy (gemcitabine, vinorelbine, and cisplatin [GVP]) prolongs overall survival in comparison to cisplatin-free (gemcitabine vinorelbine [GV]) as first-line treatment patients with advanced non-small-cell lung cancer (NSCLC). Patients Methods Between September 1999 June 2001, 300 NSCLC stage IIIB malignant pleural effusion or IV disease were randomly assigned receive GV 1000 mg/m 2 + 25 on days 1 8 every 3 weeks) GVP 75 day weeks). Primary...
Bispecific antibodies that redirect the lytic activity of cytotoxic immune effector cells, such as T- and NK onto tumor cells have emerged a highly attractive clinically validated treatment modality for hematological malignancies. Advancement this therapeutic concept into solid indications, however, is hampered by scarcity targetable antigens are surface-expressed on but demonstrate only limited expression healthy tissues. To overcome limitation, dual-targeting, i.e. simultaneous targeting...