A5061162593- Erythrocyte Function and Pathophysiology
- Parathyroid Disorders and Treatments
- Ion channel regulation and function
- Blood properties and coagulation
- Neonatal Health and Biochemistry
- Genetic Syndromes and Imprinting
- Fibroblast Growth Factor Research
- Calcium signaling and nucleotide metabolism
- Pancreatic function and diabetes
- Ion Transport and Channel Regulation
- Hemoglobinopathies and Related Disorders
- Metabolism, Diabetes, and Cancer
- Magnesium in Health and Disease
- Bone health and treatments
- Biomedical Research and Pathophysiology
- Cardiac electrophysiology and arrhythmias
- Ion Channels and Receptors
- Neuroscience and Neuropharmacology Research
- Wnt/β-catenin signaling in development and cancer
- Vitamin D Research Studies
- Genetic and Kidney Cyst Diseases
- Caveolin-1 and cellular processes
- Blood groups and transfusion
- Renal and related cancers
- Digestive system and related health
University of Hohenheim
2018-2025
Charité - Universitätsmedizin Berlin
2014-2019
Martin Luther University Halle-Wittenberg
2015-2018
Ontario Institute for Cancer Research
2012-2016
University of Tübingen
2006-2015
University Health Network
2012-2014
Health Net
2014
University of Basel
2014
TH Bingen University of Applied Sciences
2012
Cancer Institute (WIA)
2012
Suicidal death of erythrocytes, or eryptosis, is characterized by cell shrinkage and membrane scrambling leading to phosphatidylserine exposure at the surface. Eryptosis triggered increase cytosolic Ca2+ activity, which may result from treatment with ionophore ionomycin energy depletion removal glucose. The present study tested hypothesis that erythrocyte surface fosters adherence endothelial cells vascular wall under flow conditions arterial shear rates binding eryptotic mediated...
AMP-activated protein kinase (AMPK), an energy-sensing enzyme, counteracts energy depletion by stimulation of production and limitation utilization. On depletion, erythrocytes undergo suicidal death or eryptosis, triggered increase in cytosolic Ca(2+) activity ([Ca(2+)](i)) characterized cell shrinkage phosphatidylserine (PS) exposure at the erythrocyte surface. The present study explored whether AMPK participates regulation eryptosis. Western blotting confocal microscopy disclosed...
Human erythrocytes express cation channels which contribute to the background leak of Ca2+, Na+ and K+. Excessive activation these upon energy depletion, osmotic shock, Cl- or oxidative stress triggers suicidal death (eryptosis), characterized by cell-shrinkage exposure phosphatidylserine at cell surface. Eryptotic cells are supposed be cleared from circulating blood. The present study aimed identify channels. RT-PCR revealed mRNA encoding non-selective channel TRPC6 in erythroid progenitor...
Suicidal erythrocyte death (eryptosis) is characterized by cell shrinkage, membrane blebbing, and phospholipid scrambling with phosphatidylserine exposure at the surface. Eryptotic cells adhere to vascular wall are rapidly cleared from circulating blood. Eryptosis stimulated an increase in cytosolic Ca(2)+ activity, ceramide, hyperosmotic shock, oxidative stress, energy depletion, hyperthermia, a wide variety of xenobiotics endogenous substances. Inhibitors eryptosis include erythropoietin...
Hepatic failure is commonly associated with anemia, which may result from gastrointestinal bleeding, vitamin deficiency, or liver‐damaging diseases, such as infection and alcohol intoxication. At least in theory, anemia during hepatic accelerated clearance of circulating erythrocytes. Here we show that bile duct ligation (BDL) mice leads to severe despite increased reticulocyte numbers. Bilirubin stimulated suicidal death human Mechanistically, bilirubin triggered rapid Ca 2+ influx,...
Significance Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D metabolism induces left heart hypertrophy. The importance of FGF23 is supported by the consequences deficiency: FGF23-deficient mice have a significantly reduced life span recapitulate human age-associated diseases. Moreover, has gained attention as potential disease biomarker due to its positive correlation with activity, progression, outcome in chronic kidney or cardiovascular disorders. It is, however, not...
To explore the functional significance of cGMP-dependent protein kinase type I (cGKI) in regulation erythrocyte survival, gene-targeted mice lacking cGKI were compared with their control littermates. By age 10 weeks, cGKI-deficient exhibited pronounced anemia and splenomegaly. Compared mice, mutants had significantly lower red blood cell count, packed volume, hemoglobin concentration. Anemia was associated a higher reticulocyte number an increase plasma erythropoietin The spleens mutant...
Loss-of-function mutations in human adenomatous polyposis coli (APC) lead to multiple colonic polyps eventually resulting carcinoma. Similarly, heterozygous mice carrying defective APC (apc(Min/+)) suffer from intestinal tumours. The animals further anaemia, which theory could result accelerated eryptosis, a suicidal erythrocyte death triggered by enhanced cytosolic Ca(2+) activity and characterized cell membrane scrambling shrinkage. To explore, whether APC-deficiency enhances we estimated...
Activation of AMP-activated protein kinase (AMPK) upon energy depletion stimulates production and limits utilization. Erythrocytes lacking AMPK are susceptible to suicidal cell death (eryptosis). A hallmark eryptosis is membrane scrambling with phosphatidylserine exposure at the erythrocyte surface, which can be identified from annexin V-binding. AMPKα1-deficient mice (ampk(-/-)) suffer anemia due accelerated clearance erythrocytes circulating blood. To determine link between eryptotic...
Chorea-acanthocytosis is an inevitably lethal genetic disease characterized by a progressive hyperkinetic movement disorder and cognitive behavioral abnormalities as well acanthocytosis. The caused loss-of-function mutations of the gene encoding vacuolar protein sorting-associated 13A (VPS13A) or chorein, with unknown function expressed in various cell types. How chorein deficiency leads to pathophysiology chorea-acanthocytosis remains enigmatic. Here we show decreased...
Hallmarks of apoptosis include cell shrinkage, which is at least partially due to cellular K+ loss. The decline concentration has been suggested participate in the triggering apoptosis. Suicidal erythrocyte death or eryptosis triggered by increased cytosolic Ca2+ activity leading activation Ca2+-sensitive channels with subsequent loss and scambling membrane phosphatidylserine (PS) exposure surface. Phosphatidylserine exposing erythrocytes are recognized macrophages, engulfed, degraded thus...
Vitamin A and retinoic acid have previously been shown to confer some protection against a severe course of malaria by fostering the phagocytosis parasitized erythrocytes. Phagocytosis erythrocytes is stimulated phosphatidylserine exposure at cell surface. The present study has thus performed explore effect specific receptor (RAR) agonist 4-(E-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]-1-propenyl) benzoic (TTNPB) on erythrocyte annexin V binding, which reflects 24 hours...