A5008778280- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Lung Cancer Treatments and Mutations
- Cardiovascular Function and Risk Factors
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Blood Pressure and Hypertension Studies
- Health and Medical Studies
- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Treatment and Research
- Palliative Care and End-of-Life Issues
- Health Systems, Economic Evaluations, Quality of Life
- Cancer survivorship and care
- Obesity, Physical Activity, Diet
- Economic and Financial Impacts of Cancer
- Genetic Associations and Epidemiology
- Neuroendocrine Tumor Research Advances
- Adipokines, Inflammation, and Metabolic Diseases
- Colorectal Cancer Screening and Detection
- Cardiovascular and exercise physiology
- Clinical practice guidelines implementation
Otto-von-Guericke University Magdeburg
2025
Universitätsklinik für Strahlentherapie
2021-2025
University Hospital in Halle
2017-2025
University Hospital Magdeburg
2023-2025
Martin Luther University Halle-Wittenberg
2015-2024
Klinikum Magdeburg
2023
Luther University
2022
Wittenberg University
2022
Sächsische Krebsgesellschaft
2020
European Institute of Oncology
2019
Understanding the genetic architecture of cardiac structure and function may help to prevent treat heart disease. This investigation sought identify common variations associated with inter-individual variability in function.
Abstract Background Progression-free (PFS) and overall survival (OS) in UICC stage III non-small cell lung cancer (NSCLC) after definitive concurrent chemoradiotherapy (CRT) can be increased with consolidating immunotherapy. Recent studies have shown a strong predictive value of gross tumor volume (GTV) changes during CRT on OS. The TORCH trial investigated the prognostic impact GTV as predictor for response to Methods This retrospective non-interventional observational multicenter included...
Improving the sustainability and cost-effectiveness of healthcare systems has become increasingly relevant in times climate change, energy transition, an aging population skyrocketing social costs. The selection adequate fractionation schedule is fundamental importance field Radiation Oncology. We evaluated three internationally established schedules for definitive prostate cancer radiation therapy (RT) with respect to their ecological health-economic impacts.We analyzed data 109 patients...
In contrast to normal cells, tumor cells of multiple entities overexpress the Heat shock protein 70 (Hsp70) not only in cytosol, but also present it on their plasma membrane a tumor-specific manner. Furthermore, Hsp70-positive actively release Hsp70 small extracellular vesicles with biophysical characteristics exosomes. Due conformational changes lipid environment, most commercially available antibodies fail detect membrane-bound and vesicular Hsp70. To fill this gap assess role circulation...
Precise blood pressure (BP) measurements are central for the diagnosis of hypertension in clinical and epidemiological studies. The purpose this study was to quantify variability BP associated with arm side, body position, successive setting a population-based observational study. Additionally, we aimed evaluate influence different measurement conditions on prevalence hypertension. sample included 967 men 812 women aged 45 83 years at baseline. measured according standardized protocol...
Abstract Physical activity (PA) reduces the risk for mortality. Whether beneficial effects of PA are domain specific is unclear. We associated leisure time (LTPA), sports (SPA) and work (WPA) related cardiorespiratory fitness (CRF) with all-cause mortality in two German population-based cohorts. used data Study Health Pomerania (SHIP, n = 2,935, median age 53; 48% male) Cardiovascular Disease, Living Ageing Halle study (CARLA, 1,776, 64 54% male). Mortality was determined after a follow-up...
The effects of lifestyle risk factors considered collectively on the human metabolism are to date unknown. We aim investigate association these with metabolites and their changes during 4 years.One hundred sixty-three were measured in serum samples AbsoluteIDQ kit p150 (Biocrates) following a targeted metabolomics approach, population-based cohort 1030 individuals, aged 45 83 years at baseline. evaluated associations between metabolite concentrations (28 acylcarnitines, 14 amino acids, 9...
Although prostate cancer (PCa) is the most commonly diagnosed in men of sub-Saharan Africa (SSA), little known about its management and survival. The objective current study was to describe presentation, patterns diagnosis, treatment, survival patients with PCa 10 countries SSA.
Glioblastoma multiforme (GBM) is a primary malignant brain tumour characterized by very low long-term survival. The aim of this study was to analyse the distribution treatment modalities and their effect on survival for GBM cases diagnosed in Germany between 1999 2014.Cases were pooled from German Cancer Registries with International Classification Diseases Oncology, third edition (ICD-O-3) codes or giant-cell GBM. Three periods, first (January 1999-December 2005), second 2006-December 2010)...
Previous research found an association of CRP with QT time in population based samples. Even more, there is evidence a substantial involvement the tumor necrosis factor-alpha system pathophysiology cardiac arrhythmia, while role Interleukin 6 remains inconclusive.To determine between inflammation abnormally prolonged QT-time (APQT) men and women elderly general population.Data descend from baseline examination prospective, population-based Cardiovascular Disease, Living Ageing Halle (CARLA)...
To assess the change in inpatient radiotherapy related to COVID-19 lockdown measures during first wave of pandemic 2020.
Abstract Background Anaplastic thyroid carcinoma has a very poor prognosis. We analyzed the effect of surgery, radiotherapy and chemotherapy on survival time side effects in patients with ATC. Methods retrospectively all (n = 63) histologically confirmed ATC who presented at our clinic between 1989 2020. Kaplan–Meier curves cox proportional hazard models acute toxicities logistic regression models. Results Out 63 patients, 62 received radiotherapy, 74% underwent surgery 24% combined...
The new Medical Licensing Regulations 2025 (Ärztliche Approbationsordnung, ÄApprO) will soon be passed by the Federal Council (Bundesrat) and implemented step individual faculties in coming months. further development of medical studies essentially involves an orientation from fact-based to competence-based learning focuses on practical, longitudinal interdisciplinary training. Radiation oncology radiation therapy are important components therapeutic great importance for public health, both...
Disruption of metabolic homeostasis is an important factor in many diseases. Various metabolites have been linked to higher risk morbidity and all-cause mortality using metabolomics large population-based cohorts. In these studies, baseline metabolite levels were compared across subjects identify associations with health outcomes, implying the existence 'healthy' concentration ranges that are equally applicable all individuals. Here, we focused on intra-individual changes over time their...
Abstract Background In radical radiochemotherapy (RCT) of inoperable non-small-cell lung cancer (NSCLC) typical prognostic factors include T- and N-stage, while there are still conflicting data on the relevance gross tumor volume (GTV) particularly its changes during RCT. The NCT03055715 study Young DEGRO working group German Society Radiation Oncology (DEGRO) evaluated impact GTV Methods A total 21 university centers for radiation oncology from five different European countries (Germany,...
Objective To investigate the association between inflammation and selective echocardiographic parameters (EP) characteristic for ventricular hypertrophy in cross-sectional longitudinal population-based analyses. Methods Baseline (711 men, 659 women: 45–83 years) 4-year follow-up data (622 540 women) of prospective, CARdio-vascular disease, Living Ageing Halle (CARLA)study after exclusion participants with cardiacvascular diseases were analysed. Inflammation parameters: soluble tumour...
Abstract Background Stage III non-small cell lung cancer (NSCLC) represents a highly heterogeneous disease and treatment burden. Advances in imaging modality show promising results for radiotherapy planning. In this multicentric study, we evaluated the impact of PET/CT-based planning on prognosis patients with stage NSCLC. Method A retrospective observational cohort study (ARO 2017-01/NCT03055715) was conducted by young DEGRO trial group German Society Radiation Oncology (DEGRO) primary...
Background There is evidence that chronic inflammation associated with the progression/development of renal failure; however, relations in subjects preserved function remain insufficiently understood. Objective To examine association development failure a cohort elderly general population. Methods After excluding reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, incorporated 785 men 659 women (aged 45–83 years). Follow-up was performed four years after...
Arterial hypertension is a common disease with high prevalence in the general population. Left ventricular hypertrophy (LVH) an independent risk factor arterial hypertension. Electrocardiographic indices like Sokolow-Lyon index (SLI) are recommended as diagnostic screening methods for LVH. We assessed performance of SLI cohort large used electrocardiographic and echocardiographic data from prospective, population-based study CARdio-vascular Disease, Living Ageing Halle (CARLA). Linear...