A5055330564- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advances in Oncology and Radiotherapy
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- COVID-19 and healthcare impacts
- Cardiac Structural Anomalies and Repair
- Lung Cancer Research Studies
- Economic and Financial Impacts of Cancer
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Esophageal and GI Pathology
- Endometrial and Cervical Cancer Treatments
- Radiation Dose and Imaging
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Chemokine receptors and signaling
- Cancer, Stress, Anesthesia, and Immune Response
University of Cologne
2021-2025
University Hospital Cologne
2020-2025
Heinrich Heine University Düsseldorf
2024
Düsseldorf University Hospital
2024
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2022-2024
Essen University Hospital
2020
University Hospital Bonn
2016-2017
In several solid tumors, fibroblast activation protein (FAP) is overexpressed by cancer-associated fibroblasts in the tumor microenvironment. Preliminary evidence suggests that detection and staging are feasible with PET/CT imaging using [68Ga]-radiolabeled inhibitors of FAP also cervical cancer (CC). Our study aims to explore accuracy [68Ga]Ga-fibroblast inhibitor (FAPI)-46 [18F]F-FDG compared histopathological results surgical lymph node (LN) before primary chemoradiation.Seven consecutive...
Abstract Introduction In head and neck cancers (HNCs), fibroblast activation protein (FAP) is expressed by cancer-associated fibroblasts (CAFs) in the tumor microenvironment. Preliminary evidence suggests that detection staging feasible with positron emission tomography (PET/CT) imaging using [ 68 Ga]-radiolabeled inhibitors of FAP ([ Ga]Ga-FAPI-46) HNCs. This study aims to compare Ga]Ga-FAPI-46 PET/CT 18 F]-fluorodeoxy- d -glucose F]F-FDG) a focus on improved target volume definition...
Abstract Background Fibroblast activation protein (FAP) is expressed in the tumor microenvironment (TME) of various cancers. In our analysis, we describe impact dual-tracer imaging with Gallium-68-radiolabeled inhibitors FAP (FAPI-46-PET/CT) and fluorodeoxy-D-glucose (FDG-PET/CT) on radiotherapeutic management primary esophageal cancer (EC). Methods 32 patients EC, who are scheduled for chemoradiation, received FDG FAPI-46 PET/CT same day (dual-tracer protocol, 71%) or two separate days...
Abstract Introduction Locoregional recurrence (LR) is common in locally advanced head and neck cancer (HNSCC), posing challenges for treatment. We analysed outcome parameters toxicities patients being treated with radiotherapy (RT) LR-HNSCC investigated patient disease related prognostic factors this prognostically unfavourable group. Methods This analysis includes 101 RT, radio-chemotherapy (RCT) or radio-immunotherapy (RIT) between 2010 2018 at a high-volume tertiary centre. Patient...
Highlights•Off-target ILDR synergizes with anti-PD-L1 to eradicate non-irradiated tumors•The abscopal effects of depend on dosimetry (≥1 and ≤3 Gy) volume•Gut composition governs the combined anti-PD-L1•ILDR Christensenellaceae influence emigration intestinal mregDC TdLNSummaryThe mechanisms governing local radiotherapy in cancer patients remain an open conundrum. Here, we show that off-target low-dose irradiation (ILDR) increases clinical benefits immune checkpoint inhibitors or...
While immune checkpoint inhibitors (ICIs) in combination with radiotherapy (RT) are widely used for patients brain metastasis (BM), markers that predict treatment response combined RT and ICI (RT-ICI) their optimal dosing sequence the best immunogenic effects still under investigation. The aim of this study was to evaluate prognostic factors therapeutic outcome compare concurrent non-concurrent RT-ICI. We retrospectively analyzed data 93 319 BMs different cancer types who received PD-1 at...
Imaging studies with PET tracers acting as fibroblast activation protein inhibitors (FAPI) show promising results that could usefully complement [<sup>18</sup>F]-FDG in cancer imaging. <b>Methods:</b> All patients received [<sup>18</sup>F]-FDG-PET/CT and dual-tracer PET/CT after additional injection of [<sup>68</sup>Ga]Ga-FAPI-46 following the [<sup>18</sup>F]-FDG-PET/CT. Two readers visually compared detection rate analyzed target-to-background uptake ratios (TBRs) for tumor metastatic...
Abstract Background Expression of CXCR4, a chemokine (C-X-C motif) receptor that plays central role in tumor growth and metastasis circulating cells, has been described variety solid tumors. A high expression CXCR4 prognostic significance with regard to overall progression-free survival offers starting point for targeted therapies. In this context, [68]Ga-Pentixafor-Positron Emission Tomography/Computer Tomography (PET/CT) promising possibility imaging the profile. We set out compare [18F]...
Abstract Purpose Fibroblast activation protein (FAP) detected by positron-emission tomography (PET) using fibroblast inhibitor (FAPI) appears to be a promising target for cancer imaging, staging, and therapy, providing added value strength as complement [ 18 F]fluorodeoxyglucose (FDG) in imaging. We recently introduced combined single-session/dual-tracer protocol with F]FDG 68 Ga]Ga-FAPI imaging staging. Malignant tissue visualization target-to-background uptake ratios (TBRs) well functional...
Abstract Purpose The described work aimed to avoid cancellations of indispensable treatments by implementing active patient flow management practices and optimizing infrastructure utilization in the radiation oncology department a large university hospital regional COVID-19 treatment center close first German SARS-CoV‑2 hotspot region Heinsberg order prevent nosocomial infections patients personnel during pandemic. Patients methods study comprised year-to-date intervention analyses in-...
In Germany, the new Licensing Regulations for Physicians 2025 (Ärztliche Approbationsordnung, ÄApprO) define a binding legal framework on basis of which medical faculties modernize their curricula. Since 2015, National Competence Based Learning Objectives Catalogue Medicine 2.0 (Nationaler Kompetenzbasierter Lernzielkatalog 2.0., NKLM) formulates competencies and learning objectives to be achieved in course studies as curriculum orientation faculties. addition, about 80% areas core are made...
The use of positron-emission tomography (PET)/computed (CT) in radiation therapy (RT) has increased. Radiation oncologists (RadOncs) have access to PET/CT with a variety tracers for different tumor entities and it target volume definition. German Society Nuclear Medicine (DGN) the Oncology (DEGRO) aimed identify current patterns care order improve interdisciplinary collaboration.
Abstract Background Present studies on the efficacy and safety of curative chemoradiation therapy (CRT) with esophageal cancer reflect heterogenous results especially in elderly patients. The aim this study was to evaluate toxicity CRT patients ≥ 65 years. In a cohort, focus centered around treatment-related (CTCAE Grade > 3), overall survival as well progression free survival, comparing these rates in-between older than 70 years those younger Methods A total 67 (34 (50.7%) were years)...
Elderly patients > 70 years of age with esophageal cancer (EC) represent a challenging group as frailty and comorbidities need to be considered. The aim this retrospective study was evaluate the efficacy side effects curative chemoradiation therapy (CRT) regard basic geriatric screening in elderly order elucidate prognostic factors. Thirty-four EC treated at our center between May 2014 October 2018 fulfilled selection criteria for analysis. Treatment consisted intravenous infusion...
The abscopal effect (AbE) is a systemic immune response mediated by the effects of radiotherapy (RT) on system. AbE in patients with metastatic cancer treated RT alone has been seen rarely, however, era checkpoint inhibition (ICI) recognized more commonly. actual frequency RT-ICI setting unclear. We retrospectively screened receiving for progressive disease during ICI between 2015- 2021. Patients switching treatment within radiological assessment (RA) were excluded. Eligible had ≥1 NIL...
<title>Abstract</title> Introduction: Locoregional recurrence (LR) is common in locally-advanced head and neck cancer (HNSCC), posing challenges for treatment. We analysed outcome parameters toxicities patients being treated with radiotherapy (RT) LR-HNSCC investigated patient disease related prognostic factors this prognostically unfavourable group. Methods This analysis includes 101 RT, radio-chemotherapy (RCT) or radio-immunotherapy (RIT) between 2010–2018. Patient characteristics, tumour...