A5017733356- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- interferon and immune responses
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renal cell carcinoma treatment
- Adipose Tissue and Metabolism
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- Exercise and Physiological Responses
- Renal Diseases and Glomerulopathies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Effects of Radiation Exposure
Sotio (Czechia)
2019-2025
Cornell University
2025
Weill Cornell Medicine
2025
Charles University
2019-2024
University Hospital in Motol
2021-2022
Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8+ cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML). However, ICIs targeting programmed cell death 1 (PDCD1, best known as PD-1) and lymphocyte-associated protein 4 (CTLA4) have limited clinical efficacy patients with AML. Natural killer (NK) cells are central players AML-targeting responses. little is on the relationship between co-inhibitory receptors expressed...
While type I interferon (IFN) is best known for its key role against viral infection, accumulating preclinical and clinical data indicate that robust IFN production in the tumor microenvironment promotes cancer immunosurveillance contributes to efficacy of various antineoplastic agents, notably immunogenic cell death inducers. Here, we report malignant blasts from patients with acute myeloid leukemia (AML) release via a Toll-like receptor 3 (TLR3)-dependent mechanism not driven by treatment....
In some settings, cancer cells responding to treatment undergo an immunogenic form of cell death that is associated with the abundant emission danger signals in damage-associated molecular patterns. Accumulating preclinical and clinical evidence indicates play a crucial role (re-)activation antitumor immune responses vivo, thus having major impact on patient prognosis. We have previously demonstrated presence calreticulin surface malignant blasts positive prognostic biomarker for patients...
Highlights•Off-target ILDR synergizes with anti-PD-L1 to eradicate non-irradiated tumors•The abscopal effects of depend on dosimetry (≥1 and ≤3 Gy) volume•Gut composition governs the combined anti-PD-L1•ILDR Christensenellaceae influence emigration intestinal mregDC TdLNSummaryThe mechanisms governing local radiotherapy in cancer patients remain an open conundrum. Here, we show that off-target low-dose irradiation (ILDR) increases clinical benefits immune checkpoint inhibitors or...
Dendritic cells (DCs) have received considerable attention as potential targets for the development of novel cancer immunotherapies. However, clinical efficacy DC-based vaccines remains suboptimal, largely reflecting local and systemic immunosuppression at baseline. An autologous vaccine (DCVAC) has recently been shown to improve progression-free survival overall in randomized trials enrolling patients with lung (SLU01, NCT02470468) or ovarian carcinoma (SOV01, NCT02107937), but not...
Abstract The mammalian body possesses remarkable adaptability to cold exposure, involving intricate adjustments in cellular metabolism, ultimately leading thermogenesis. However, cold‐induced stress can impact immune response, primarily through noradrenaline‐mediated pathways. In our study, we utilized a rat model subjected short‐term or long‐term mild exposure investigate systemic response during the acclimation. To provide human relevance, included group of regular swimmers study. Our...
Abstract Epithelial ovarian carcinoma (EOC) is among the top five causes of cancer-related death in women. Most women with EOC achieve indeed complete remission after primary or interval cytoreductive surgery combined chemotherapy based on a platinum-taxane doublet. Homologous recombination (HR) defects imposed by germline somatic BRCA1 DNA repair-associated (BRCA1) BRCA2 mutations are not only key determinants platinum sensitivity patients but also provide strong rationale for maintenance...
Abstract Epithelial ovarian carcinoma (EOC) is one of the top five causes cancer-related death in women. Most patients with EOC achieve initial remission after primary or interval cytoreductive surgery combined platinum-taxane chemotherapy. However, mutations BRCA1 BRCA2 genes, which lead to homologous recombination (HR) defects, play a crucial role platinum sensitivity and justify use poly (ADP-ribose) polymerase (PARP) inhibitors as maintenance therapy, commonly linked extended...
<h3></h3> In some settings, cancer cells responding to treatment undergo an immunogenic form of cell death that is associated with the abundant emission danger signals in damage-associated molecular patterns. Accumulating preclinical and clinical evidence indicates play a crucial role (re-)activation antitumor immune responses vivo, thus having major impact on patient prognosis. We have previously demonstrated presence calreticulin surface malignant blasts positive prognostic biomarker for...
Abstract Epithelial ovarian carcinoma (EOC) is among the top five causes of cancer-related death in women. Most women with EOC achieve indeed complete remission after primary or interval cytoreductive surgery combined chemotherapy based on a platinum-taxane doublet. Homologous recombination (HR) defects imposed by germline somatic BRCA1 DNA repair-associated (BRCA1) BRCA2 mutations are not only key determinants platinum sensitivity patients but also provide strong rationale for maintenance...
Abstract In some settings, cancer cells responding to treatment undergo an immunogenic form of cell death that is associated with the abundant emission danger signals in damage-associated molecular patterns (DAMPs). Accumulating preclinical and clinical evidence indicates play a crucial role (re-)activation antitumor immune responses vivo, thus having major impact on patient prognosis. We have previously demonstrated presence calreticulin (CRT) surface malignant blasts positive prognostic...