A5031324764- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Neuroendocrine Tumor Research Advances
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- Cardiac Imaging and Diagnostics
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Chemokine receptors and signaling
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Multiple Myeloma Research and Treatments
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Adrenal and Paraganglionic Tumors
- Cardiac Structural Anomalies and Repair
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Glioma Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Immunotherapy and Immune Responses
- Vasculitis and related conditions
- Cardiac Fibrosis and Remodeling
Ludwig-Maximilians-Universität München
1988-2025
Johns Hopkins University
2017-2025
Goethe University Frankfurt
2023-2025
Universitätsklinikum Würzburg
2015-2025
University Hospital Frankfurt
2023-2025
LMU Klinikum
1988-2025
European Neuroendocrine Tumor Society
2018-2025
Klinik und Poliklinik für Nuklearmedizin
2021-2025
Johns Hopkins Medicine
2017-2024
German Centre for Cardiovascular Research
2024
Dosimetry of organs and tumors helps to assess risks benefit treatment with <sup>177</sup>Lu-DOTATATE/DOTATOC. However, it is often not performed in clinical routine because additional efforts, the complexity data collection analysis, burden for patients. Aiming at a simplification dosimetry, we analyzed accuracy theoretically substantiated approximation, which allows calculation absorbed doses from single measurement abdominal activity distribution. <b>Methods:</b> Activity kinetics were...
C-X-C-motif chemokine receptor 4 (CXCR4) is a key factor for tumor growth and metastasis in several types of human cancer.We have recently reported promising first-in-man experience with CXCR4-directed endoradiotherapy (ERT) multiple myeloma (MM).Eight heavily pretreated MM patients underwent total 10 ERT cycles (7 1 cycle single patient 3 cycles).ERT was administered combination chemotherapy autologous stem cell support.End points were occurrence timing adverse events, progression-free...
C-X-C motif chemokine receptor 4 (CXCR4) and somatostatin receptors (SSTR) are overexpressed in gastro-entero-pancreatic neuroendocrine tumors (GEP-NET).In this study, we aimed to elucidate the feasibility of non-invasive CXCR4 positron emission tomography/computed tomography (PET/CT) imaging GEP-NET patients using [ 68 Ga]Pentixafor comparison Ga-DOTA-D-Phe-Tyr3-octreotide ([ Ga]DOTATOC) 18 F-fluorodeoxyglucose F]FDG).Twelve with histologically proven (3xG1, 4xG2, 5xG3) underwent...
Even as medical data sets become more publicly accessible, most are restricted to specific conditions. Thus, collection for machine learning approaches remains challenging, and synthetic augmentation, such generative adversarial networks (GAN), may overcome this hurdle. In the present quality control study, deep convolutional GAN (DCGAN)-based human brain magnetic resonance (MR) images were validated by blinded radiologists. total, 96 T1-weighted from 30 healthy individuals 33 patients with...
We have recently reported on our experience with C-X-C-motif chemokine receptor 4 (CXCR4)–directed radioligand therapy (RLT) in multiple myeloma and acute leukemia. <b>Methods:</b> Six patients heavily pretreated relapsed diffuse large B-cell lymphoma (3 men, 3 women; aged, 54 ± 8 y) underwent CXCR4-directed RLT combination conditioning chemotherapy allogeneic stem cell transplantation. In 2 patients, radioimmunotherapy targeting CD20 or CD66 was added to enhance antilymphoma activity....
In recent years, molecular imaging addressing the C-X-C motif chemokine receptor 4 (CXCR4) has increasingly been used in various clinical settings. Here, we aimed to assess radiopharmaceutical uptake and image contrast determine most relevant applications for CXCR4-directed imaging. We also investigated impact of specific activity on scan contrast. Methods: Patients (n = 690) with a variety neoplasms underwent total 777 PET/CT scans 68Ga-Pentixafor, serving as CXCR4-specific radioligand. A...
Prostate-specific Membrane Antigen Reporting and Data System (PSMA-RADS) was introduced for standardized reporting, PSMA-RADS version 1.0 allows classification of lesions based on their likelihood representing a site prostate cancer PSMA-targeted positron emission tomography (PET). In recent years, this system has extensively been investigated. Increasing evidence accumulated that the different categories reflect actual meanings, such as true positivity in 4 5 lesions. Interobserver...
We report the case of a 33-year-old woman with chronic calcifying pancreatitis in whom an intraductal pancreatic stone diameter 8 mm was successfully disintegrated extracorporeal shock waves, permitting subsequent endoscopic extraction fragments. The patient had mild attack after treatment. conclude that shockwave lithotripsy duct patients is possible. It should, however, be viewed reservation until further experience has been gained.
// Constantin Lapa 1, * , Theresa Reiter 2, 3, Malte Kircher 1 Andreas Schirbel Rudolf A. Werner Theo Pelzer 2 Carmen Pizarro 4 Dirk Skowasch Lena Thomas 5 Ulrike Schlesinger-Irsch 6 Daniel Ralph Bundschuh Wolfgang R. Bauer Florian C. Gärtner 5, Department of Nuclear Medicine, University Hospital Würzburg, Germany Internal 3 Comprehensive Heart Failure Center, Medicine II - Pneumology/Cardiology, Bonn, Radiology, These authors have contributed equally to this work Correspondence...
Objective Cardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease incompletely understood. Although it associated with arrhythmias, myocardial damage, elevated enzymes, plasma catecholamines in the acute phase, nothing known about delayed consequences of on cardiovascular function. Methods To determine long‐term...
Early identification of aggressive disease could improve decision support in pancreatic neuroendocrine tumor (pNET) patients prior to peptide receptor radionuclide therapy (PRRT). The prognostic value intratumoral textural features (TF) determined by baseline somatostatin (SSTR)-positron emission tomography (PET) before PRRT was analyzed. Thirty-one with G1/G2 pNET were enrolled (G2, n = 23/31). Prior [177Lu]DOTATATE (mean, 3.6 cycles), SSTR-PET computed performed. By segmentation 162...
<sup>18</sup>F-<i>N</i>-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (<sup>18</sup>F-LMI1195) is a new PET tracer designed for noninvasive assessment of sympathetic innervation the heart. The <sup>18</sup>F label facilitates imaging advantages over SPECT technology while allowing centralized manufacturing. Highly specific neural uptake <sup>18</sup>F-LMI1195 has previously been established, but retention kinetics are not yet fully understood. <b>Methods:</b> Healthy New Zealand White...
Reliable standards and criteria for somatostatin receptor (SSTR) PET are still lacking. We herein propose a structured reporting system on 5-point scale SSTR imaging, titled SSTR-RADS version 1.0, which might serve as standardized assessment both diagnosis treatment planning in neuroendocrine tumors. could guide the imaging specialist interpreting scans, facilitate communication with referring clinician so that appropriate workup equivocal findings is pursued, reliable tool patient selection...
// Rudolf A. Werner 1,* , Constantin Lapa Harun Ilhan 2 Takahiro Higuchi 1 Andreas K. Buck Sebastian Lehner Peter Bartenstein Frank Bengel 3 Imke Schatka 4 Dirk O. Muegge 5 László Papp 6 Norbert Zsótér 7 Tobias Große-Ophoff 8 Markus Essler and Ralph Bundschuh Department of Nuclear Medicine, University Hospital Würzburg, Germany Ludwig-Maximilians-University Munich, Hannover Medical School, Hannover, Charité - Universitätsmedizin Berlin,...
Despite histological evidence in various solid tumor entities, available experience with CXCR4-directed diagnostics and endoradiotherapy mainly focuses on hematologic diseases. With the goal of expanding application CXCR4 theranostics to tumors, we aimed elucidate feasibility CXCR4-targeted imaging a variety such neoplasms. Methods: Nineteen patients newly diagnosed, treatment-naïve tumors including pancreatic adenocarcinoma or neuroendocrine tumor, cholangiocarcinoma, hepatocellular...