A5002999435- Multiple Myeloma Research and Treatments
- GDF15 and Related Biomarkers
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Neonatal Respiratory Health Research
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- Nuclear Receptors and Signaling
- Macrophage Migration Inhibitory Factor
- Chronic Myeloid Leukemia Treatments
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Immune cells in cancer
- Epigenetics and DNA Methylation
Universitätsklinikum Würzburg
2022-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2022
Vita-Salute San Raffaele University
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Abstract Disseminated cancer cells frequently lodge near vasculature in secondary organs. However, our understanding of the cellular crosstalk invoked at perivascular sites is still rudimentary. Here, we identify intercellular machinery governing formation a pro-metastatic vascular niche during breast colonization lung. We show that specific secreted factors, induced metastasis-associated endothelial (ECs), promote metastasis mice by enhancing stem cell properties and viability cells....
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don't respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response checkpoint-based immunotherapy. Based on in vitro pharmacological studies, mouse models analyses of human melanoma patients, we show that cytokine GDF-15 impairs LFA-1/β2-integrin-mediated adhesion cells activated endothelial cells, which a pre-requisite extravasation....
Abstract In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that in PDAC cells needed the recruitment of PAF1c transcription elongation complex to RNA polymerase depletion CTR9, a subunit, enables long-term survival PDAC-bearing mice. largely dispensable normal proliferation regulation target genes. Instead, limits DNA damage associated with by being essential expression long genes involved...