A5034249297- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Extracellular vesicles in disease
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Laser-induced spectroscopy and plasma
- Neurobiology and Insect Physiology Research
- RNA and protein synthesis mechanisms
- Microtubule and mitosis dynamics
- Invertebrate Immune Response Mechanisms
- Cancer-related Molecular Pathways
- Laser-Plasma Interactions and Diagnostics
- Laser-Matter Interactions and Applications
- Cancer-related gene regulation
- Developmental Biology and Gene Regulation
- Laser Material Processing Techniques
- Signaling Pathways in Disease
- Wnt/β-catenin signaling in development and cancer
- DNA Repair Mechanisms
- Renal and related cancers
- Photodynamic Therapy Research Studies
- Protein Kinase Regulation and GTPase Signaling
- Optical Imaging and Spectroscopy Techniques
University of Würzburg
2010-2025
Institute of Structural and Molecular Biology
2024
University of Leeds
2024
Universitätsklinikum Würzburg
2023-2024
Comprehensive Cancer Center Mainfranken
2015-2024
Oncode Institute
2023
Helmholtz Zentrum München
2023
Ludwig-Maximilians-Universität München
2023
Technion – Israel Institute of Technology
2023
Goethe Institute
2023
Cyclin proteins form complexes with members of the p34cdc2 kinase family and they are essential components cell cycle regulatory machinery. They thought to determine timing activation, subcellular distribution, and/or substrate specificity cdc2-related kinases, but their precise mode action remains be elucidated. Here we report cloning sequencing avian cyclin B2. Based on use monospecific antibodies raised against bacterially expressed protein, also describe distribution B2 in chick embryo...
A multi-center study has been set up to accurately characterize the optical properties of diffusive liquid phantoms based on Intralipid and India ink at near-infrared (NIR) wavelengths.Nine research laboratories from six countries adopting different measurement techniques, instrumental set-ups, data analysis methods determined their best relative uncertainties dilutions prepared with common samples two compounds.By exploiting a suitable statistical model, comprehensive reference values three...
The proteins encoded by the myc proto-oncogene family are involved in cell proliferation, apoptosis, differentiation, and neoplasia. Myc acts through dimerization with Max to bind DNA activate transcription. Homologs of max genes were cloned from fruit fly Drosophila melanogaster their protein products (dMyc dMax) shown heterodimerize, recognize same sequence as vertebrate homologs, dMyc is likely gene diminutive ( dm ), a mutation which results small body size female sterility caused...
The transcriptional regulator BRD4 has been shown to be important for the expression of several oncogenes including MYC. Inhibiting broad antiproliferative activity in different cancer cell types. small molecule JQ1 blocks interaction with acetylated histones leading modulation. Depleting via engineered bifunctional molecules named PROTACs (proteolysis targeting chimeras) represents next-generation approach JQ1-mediated inhibition. trigger proteasomale degradation by recruiting E3 ligases....
Abstract RNA-binding proteins emerge as effectors of the DNA damage response (DDR). The multifunctional non-POU domain-containing octamer-binding protein NONO/p54nrb marks nuclear paraspeckles in unperturbed cells, but also undergoes re-localization to nucleolus upon induction double-strand breaks (DSBs). However, NONO nucleolar is poorly understood. Here we show that topoisomerase II inhibitor etoposide stimulates production RNA polymerase II-dependent, damage-inducible antisense intergenic...
The transcription factor dMyc is the sole Drosophila ortholog of vertebrate c-myc protooncogenes and a central regulator growth cell-cycle progression during normal development. We have investigated molecular basis function by analyzing its interaction with putative transcriptional cofactors Tip48/Reptin (Rept) Tip49/Pontin (Pont). demonstrate that Rept Pont conserved their ability to bind Myc evolution. All three proteins are required for tissue in vivo, because mitotic clones mutant either...
Myc proteins are essential regulators of animal growth during normal development, and their deregulation is one the main driving factors human malignancies. They function as transcription that (in vertebrates) control many growth- proliferation-associated genes, in some contexts contribute to global gene regulation. We combine chromatin immunoprecipitation-sequencing (ChIPseq) RNAseq approaches Drosophila tissue culture cells identify a core set less than 500 target whose salient resides...
Protein synthesis is an essential process, deregulated in multiple tumor types showing differential dependence on translation factors compared to untransformed tissue. We show that colorectal cancer (CRC) with loss-of-function mutation the APC suppressor depends oncogenic program regulated by ability sense phosphorylated eIF2α (p-eIF2α). Despite increased protein rates following loss, phosphorylation, typically associated inhibition, enhanced CRC. Elevated p-eIF2α, and its proper sensing...
ABSTRACT Cyclins control the activities of cyclin-dependent protein kinases (cdks) and hence play a key role in cell cycle regulation. While B-type cyclins associate with p34cdc2 to trigger entry into mitosis, progression through S phase requires cyclin A, presumably association p33cdk2. Vertebrate A- display strikingly distinct subcellular localizations, but mechanisms underlying these differential distributions are unknown. Here, we have begun study requirements for nuclear localization A....
ABSTRACT This article describes the characterization of a new Drosophila gene that we have called pitchoune (pit) (meaning small in Provence) because mutations this produce larvae cannot grow beyond first instar larval stage although they can live as long 7-10 days. All tissues are equally affected and perfectly shaped indistinguishable from wild-type animals. Analysis mutant somatic clones suggests function cell growth proliferation, which is supported by fact proliferation promoted pit...
The human c-myc proto-oncogene, implicated in the control of many cellular processes including cell growth and apoptosis, encodes three isoforms which differ their N-terminal region. functions these have never been addressed vivo. Here, we used Drosophila melanogaster to examine a fully integrated system. First, established that c-Myc protein can rescue lethal mutations myc ortholog, dmyc, demonstrating biological relevance this model. Then, characterized new dmyc insertion allele, permits...
AbstractMyc is a transcription factor with diverse biological effects ranging from the control of cellular proliferation and growth to induction apoptosis. Here we present comprehensive analysis transcriptional targets sole Myc ortholog in Drosophila melanogaster, dMyc. We show that genes are down-regulated response dmyc inhibition largely identical those up-regulated after dMyc overexpression many them play role control. The promoter regions these characterized by presence E-box sequence...