A5000633602- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- TGF-β signaling in diseases
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chromatin Remodeling and Cancer
- Circular RNAs in diseases
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Muscle Physiology and Disorders
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- BRCA gene mutations in cancer
- Lung Cancer Research Studies
- Pluripotent Stem Cells Research
- Gene expression and cancer classification
- Cancer Cells and Metastasis
- Spectroscopy Techniques in Biomedical and Chemical Research
Ruhr University Bochum
2016-2025
Universitätsklinikum Knappschaftskrankenhaus Bochum
2004-2025
University of Würzburg
2025
Universitätsklinikum Würzburg
2025
Goethe University Frankfurt
2025
Icahn School of Medicine at Mount Sinai
2025
St. Josef-Hospital
2022
Essen University Hospital
2006-2022
Technical University of Munich
2022
TU Dortmund University
2022
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel were analyzed for convergent sites homozygous deletion. Twenty-five 84 tumors had deletions 18q21.1, site that excludes DCC (a gene colorectal cancer) and includes DPC4 , similar in sequence to Drosophila melanogaster ( Mad ) implicated transforming growth factor-β (TGF-β)-like signaling pathway. Potentially inactivating mutations identified six 27...
Mutations in the SMAD4/DPC4 tumor suppressor gene, a key signal transducer most TGFβ-related pathways, are involved 50% of pancreatic cancers. Homozygous Smad4 mutant mice die before day 7.5 embryogenesis. Mutant embryos have reduced size, fail to gastrulate or express mesodermal marker, and show abnormal visceral endoderm development. Growth retardation -deficient results from cell proliferation rather than increased apoptosis. Aggregation ES cells with wild-type tetraploid morulae rescues...
Background: Although as many 10% of pancreatic cancer cases may have an inherited component, familial has not been linked to defects in any specific gene. Some studies shown that families with germline mutations the breast susceptibility gene BRCA2 increased risk and ovarian cancers, well a modestly cancer. To study these relationships more detail, we examined whether are associated Methods: We identified 26 European which at least two first-degree relatives had histologically confirmed...
Smad4/ DPC4 (deleted in pancreatic carcinoma, locus 4) is a tumor suppressor gene lost at high frequency cancers of the pancreas and other gastrointestinal organs. Smad4 encodes key intracellular messenger transforming growth factor β (TGF-β) signaling cascade. TGF-β potent inhibitor epithelial cells; thus, it has been assumed that loss during progression relieves this inhibition. Herein, we show restoration to human carcinoma cells suppressed formation vivo , yet did not restore sensitivity...
MicroRNAs (miRNAs) are RNA molecules that involved in the regulation of many cellular processes, including those related to human cancers. The aim this study was determine, as a proof principle, whether specific candidate miRNAs could be detected fine-needle aspirate (FNA) biopsies pancreatic ductal adenocarcinoma (PDAC) and accurately differentiate malignant from benign tissues.We used TaqMan(R) assays quantify miRNA levels FNA samples collected RNARetain (n = 16) compared results with...
Perturbations in the expression profiles of microRNAs (miRNAs) have been reported for a variety different cancers. Differentially expressed miRNAs not systematically evaluated basal cell carcinoma (BCC) skin.To initiate microarray-based miRNA profiling study to identify specific candidates that are differentially BCC.Patients with BCC (n = 7) were included this study. Punch biopsies harvested from tumour centre (lesional, n and adjacent nonlesional skin (intraindividual control, 7)....
Malignant gliomas are the most common and lethal primary intracranial tumors. To date, no reliable biomarkers for detection risk stratification of have been identified. Recently, we demonstrated significant levels microRNAs (miRNAs) to be present in cerebrospinal fluid (CSF) samples from patients with CNS lymphoma. Because involvement miRNA carcinogenesis, miRNAs CSF may serve as unique minimally invasive diagnosis glioma. The objective this pilot study was identify differentially expressed...
MicroRNAs (miRNAs) are small non-coding RNAs that involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported colon carcinoma. To elucidate its potential role cancer, was overexpressed via a lentiviral vector system two cancer cell lines. This induced both lines miR-30a-5p-mediated growth inhibition, attributable to cycle arrest at the G 1 phase and an induction apoptosis. Combining global analyses transgenic line...
Improved non-invasive strategies for early cancer detection are urgently needed to reduce morbidity and mortality. Non-coding RNAs, such as microRNAs small nucleolar have been proposed biomarkers diagnosis. Analyzing serum derived from nude mice implanted with primary human pancreatic ductal adenocarcinoma (PDAC), we identified 15 diagnostic microRNA candidates. Of those miR-1246 was selected based on its high abundance in of tumor carrying mice. Subsequently, noted a cross reactivity the...