A5051225940- Microtubule and mitosis dynamics
- Photosynthetic Processes and Mechanisms
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Genomics and Chromatin Dynamics
- Cellular transport and secretion
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Adrenal Hormones and Disorders
- Nuclear Structure and Function
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Plant nutrient uptake and metabolism
- RNA modifications and cancer
- Protein Structure and Dynamics
- Protist diversity and phylogeny
- Thyroid Disorders and Treatments
- DNA Repair Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Renal function and acid-base balance
- Cancer therapeutics and mechanisms
- Neuroblastoma Research and Treatments
University of Leeds
2016-2025
Institute of Structural and Molecular Biology
2006-2024
University of Würzburg
2024
Universitätsklinikum Würzburg
2024
Comprehensive Cancer Center Mainfranken
2024
Institute of Cancer Research
2008-2020
University of Leicester
2007-2019
Cancer Research UK
2014-2016
Jagiellonian University
2009
Institute of Medicinal Plant Development
2009
The interaction between nuclear pore proteins (nucleoporins) and transport factors is crucial for the translocation of macromolecules through pores. Many nucleoporins contain FG sequence repeats, previous studies have demonstrated interactions repeats containing FxFG or GLFG cores factors. crystal structure residues 1-442 importin-beta bound to a peptide indicates that this repeat core binds same primary site as cores. Importin-beta-I178D shows reduced binding both consistent with an...
Inherited microcephaly exposes Zika culprit Microcephaly has been the terrifying hallmark of recent outbreak virus (ZIKV) in Americas. How damages brain development fetus is enigmatic. Chavali et al. found that congenital microcephaly, mutations a neural precursor protein, Musashi-1 (MSI1), impede RNA binding to stem cell targets, resulting abnormal (see Perspective by Griffin). MSI1 also binds ZIKV amplify viral replication cells. This interaction could put pregnant woman at risk giving...
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Summary Brassinosteroids, which control plant growth and development, are sensed by the membrane receptor kinase BRASSINOSTEROID INSENSITIVE 1 ( BRI 1). Brassinosteroid binding to leucine‐rich repeat LRR ) domain induces heteromerisation with a SOMATIC EMBRYOGENESIS RECEPTOR KINASE SERK )‐family co‐receptor. This process allows cytoplasmic domains of interact, trans ‐phosphorylate activate each other. Here we report crystal structures in its activated form complex nucleotides. has structural...
Myc family proteins promote cancer by inducing widespread changes in gene expression. Their rapid turnover the ubiquitin-proteasome pathway is regulated through phosphorylation of Box I and ubiquitination E3 ubiquitin ligase SCF
Significance Echinoderm microtubule-associated protein (EMAP)-like (EML) proteins normally function in the cytoskeleton. In some lung cancers, genetic abnormalities generate oncogenic fusion EML4-anaplastic lymphoma kinase (ALK) on which cancer cells depend for survival. We have determined molecular structure of a conserved, tubulin-binding region EML1 that reveals an unexpected fold. This is disrupted ∼70% EML4-ALK fusions found patients, causing them to be sensitive drugs target Hsp90,...
Highlights•N-MYC forms complexes with TFIIIC, RAD21, and TOP2A•TFIIIC recruits RAD21 is required for N-MYC-dependent pause release of Pol II•Aurora-A displaces TOP2A, from N-MYC during S phase•Aurora-A inhibits II phaseSummaryMYC proteins bind globally to active promoters promote transcriptional elongation by RNA polymerase (Pol II). To identify effector that mediate this function, we performed mass spectrometry on in neuroblastoma cells. The analysis shows a subunit cohesin. TFIIIC...
Sylvia and Jim Tait's Quartet is in part a scientific autobiography review of endocrine advances made during their working lives. It focuses on four research projects to which the two important contributions before Tait died 2003.
Type IV secretion systems (T4SSs) are commonly used machineries in Gram-negative bacteria. They the infection of human, animal, or plant cells and propagation antibiotic resistance. The T4SS apparatus spans both membranes bacterium generally is composed 12 proteins, named VirB1–11 VirD4 after proteins canonical Agrobacterium tumefaciens T4SS. periplasmic core complex VirB8/VirB10 structurally functionally links cytoplasmic NTPases system with its outer membrane pilus components. Here we...