EDWARDS, OWEN M. M.D., F.R.C.P.; CLARK, JOHN D. A. M.B.Ch.B., M.R.C.P. Author Information

Abstract Introduction Transcranial Doppler ultrasonography (TCD) and Near-Infrared spectroscopy (NIRS) are indirect measures of neurovascular coupling (NVC). NVC is the relationship between cerebral blood flow neuronal activity to meet metabolic demands brain. No studies have integrated TCD-NIRS investigate feasibility measuring in those with dementia, delirium, depression. Methods 32 participants (median [IQR] age 73.0 [70.0,78.5], 50% female, healthy (HC, n = 10), depression (n 11),...

Unilateral renal agenesis is an uncommon association with Kallmann's syndrome (KS) (hypogonadotrophic hypogonadism and olfactory defect). We have investigated affected individuals from six pedigrees: five X‐linked KS, one KS ichthyosis (XLI). Seventeen had imaging performed, scans demonstrated only kidney. In addition, two pedigrees males who died in the neonatal period bilateral agenesis. Only of four family (Pedigree 6) showed unilateral agenesis, despite all patients demonstrating...

SUMMARY In a study of 250 patients with autoimmune thyroid disease, seven (2.8%) were found to have polymyalgia rheumatica or giant cell arteritis. All cases occurred in female over the age 60 years, prevalence this group 9.3%. No either disorder seen control population 150 50 years attending cardiac clinic at same hospital. Awareness association may allow earlier diagnosis and treatment syndrome elderly disease.

SUMMARY As judged by the urinary excretion of free noradrenaline and adrenaline, secretion catecholamines is not increased in patients with Graves' disease. Catecholamine was reduced treatment propranolol or carbimazole singly combination. The possible mechanism hyperthyroidism responsible for apparent increase sympathetic nervous activity mitigation these features discussed.

SUMMARY Nine female patients with normal serum total thyroxine (T4) and triiodothyronine (T3) but elevated thyroid stimulating hormone (TSH) levels were studied. Six had generalised oedema associated maximal diurnal weight gains in excess of 1.4 kg. Under conditions forced water diuresis, before during physiological replacement 1‐thyroxine, the supine transcapillary escape rate albumin (TERA) was measured, while venous colloid osmotic pressure (COP), packed cell volume (PCV) urinary exretion...

Abstract Aims To determine the nature of association between baseline albuminuria and risk all‐cause mortality cardiovascular disease, to if rate change from over 1 year predicts these endpoints in patients with diabetic nephropathy. Methods Cohort study 427 (161 Type 266 2) nephropathy defined as urinary albumin excretion (UAE) ≥ 30 mg/24 h at (mean age 53.4 years). Patients were recruited time referral a clinic followed up annually for an average 5 years. UAE was re‐measured calculated....

Endocrine studies, using the four hypothalamic releasing hormones, gonadotrophin hormone, thyrotrophin corticotrophin hormone and growth were performed in 33 males after admission with a major head injury. The test was repeated 7 days later all patients 3-6 months 21 patients. All had period of unconsciousness followed by post-traumatic amnesia greater than 24 h. results obtained from investigating gonadal axis are reported this paper. levels total free testosterone, basal FSH LH fell...

A clinical and investigative study is reported of 19 patients with ‘idiopathic oedema women’. The reasons for defining this as a specific syndrome unrelated to the menstrual cycle are given, features reviewed. During forced water diuresis flow composition urine plasma volume were studied on tilting from supine upright position seven premenopausal four postmenopausal disorder. No differences found in results obtained follicular luteal phases or pre- post-menopausal patients. reductions...

Renal function was assessed in 18 patients who had consumed 2 to 30 kg of paracetamol. No relationship found between the total amount paracetamol taken and any aspect renal studied. patient clinically significant impairment. Thirteen showed no deterioration over a period about one year during which they an additional mean

Oxytetracycline given to two patients with impaired renal function produced clinical deterioration and increasing azotaemia. Both improved when oxytetracycline was stopped. In general tetracycline should not be used in poor function, but if it is necessary the blood urea level checked frequently.

Three patients with insulin‐dependent diabetes mellitus are described in whom generalized oedema and weight gain followed the administration of excessive monocomponent insulins, two cases associated symptomatic hypoglycaemia. Serial measurements plasma volume transcapillary escape rate albumin (TERA) using 125 I‐labelled albumin, serum colloid osmotic pressure (COP) a membrane osmometer, packed cell (PCV), proteins, showed that was an increased TERA, while total protein concentration COP...

Six obese subjects were studied over a period of 12 weeks whilst on 1260 kJ (300 kcal) formula diet. Weight loss was initially rapid, but later slowed markedly despite good patient compliance. The basal metabolic rate (BMR) fell in all patients during the study. Plasma triiodothyronine patients, plasma half-life thyroxine increased. thyroxine, reverse (reverse T3) and serum prolactin thyrotropin response to thyroliberin showed no significant change.

suggest a need to re-evaluate strategies for managing high blood pressure in very old patients.This study was supported by grant NIADDKD AM31801. 1

Using assays that specifically measure insulin, intact proinsulin, and 32,33 split we examined the β-cell secretory response to an oral glucose tolerance test (OGTT) in 64 women with gestational diabetes mellitus (GDM) 154 pregnant normoglycemic control subjects of comparable age body mass index. Women GDM were characterized by a lower 30-min insulin increment (40.8 [34.9–47.6] vs. 58.6 [53.6–64] pmol insulin/mmol glucose, P < 0.001; geometric mean [95% confidence interval]) higher...

Abstract Species range shifts due to climate alterations have been increasingly well‐documented. Although amphibians are one of the most sensitive groups animals environmental perturbations change, almost no studies offered evidence poleward distribution in this taxon response warming. Range would be facilitated by variation traits associated with ability species persist and/or shift their face but extent and consequences intraspecific these is unclear. We studied role ongoing green...

Good control of blood glucose concentration in insulin-dependent diabetics leads to fewer complications. Monitoring is therefore central the management patients with diabetes. This achieved both by frequent measurement concentrations and glycated haemoglobin (sometimes referred as A1c (HbA1c)). There have been a few isolated reports that subject seasonal variation diabetics, children Britain adults Sweden. clearly important interpreting changes response therapeutic interventions. Here we...

Antithyroid drugs are commonly used as first-line treatment for Graves' disease, but the optimum regimen inducing remission remains unclear. We gave block-replace of carbimazole plus thyroxine to 100 patients 6 or 12 months, determine whether prolonged is associated with fewer relapses. The rate one year after cessation was 59% month course and 65% months; this not significantly different. also analysed HLA markers identified by restriction fragment length polymorphisms could confirm...

1. Water and electrolyte excretion has been measured in both the follicular luteal phases of menstrual cycle eight normal females undergoing a sustained water diuresis. 2. When subjects were supine, no differences found urinary during phases. 3. tilted to upright position, urine volume, sodium potassium osmolar free clearances fell, suggesting an alteration proximal tubular function. These changes statistically greater than phase cycle. 4. It is postulated that enhanced retention...