A5079070105- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Algal biology and biofuel production
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Protein purification and stability
- Metabolomics and Mass Spectrometry Studies
- Microbial Metabolic Engineering and Bioproduction
- Asthma and respiratory diseases
- Aquatic Ecosystems and Phytoplankton Dynamics
- Immune Cell Function and Interaction
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Inhalation and Respiratory Drug Delivery
University of Würzburg
2019-2025
Universitätsklinikum Würzburg
2018-2025
Institut für Hämatopathologie Hamburg
2020-2025
Max Planck Institute of Molecular Plant Physiology
2013-2018
Hexal (Germany)
2018
Martin Luther University Halle-Wittenberg
2016
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015
Hospital del Mar Research Institute
2013-2014
Municipal Institute for Medical Research
2013-2014
Hospital Del Mar
2013-2014
The oxygen sensitive alpha-subunit of the hypoxia-inducible factor-1 (HIF-1) is a major trigger cellular response to hypoxia. Although posttranslational regulation HIF-1alpha by hypoxia well known, its transcriptional still under debate. We, therefore, investigated mRNA in pulmonary artery smooth muscle cells. Hypoxia rapidly enhanced levels and promoter activity. Furthermore, inhibition phosphatidylinositol 3-kinase (PI3K)/AKT but not extracellular signal-regulated kinase 1/2 pathway...
Future sustainable energy production can be achieved using mass cultures of photoautotrophic microorganisms, which are engineered to synthesize valuable products directly from CO2 and sunlight. As cyanobacteria cultivated in large scale on non-arable land, these phototrophic bacteria have become attractive organisms for biofuels. Synechococcus sp. PCC 7002, one the cyanobacterial model organisms, provides many properties biofuel such as tolerance seawater high light intensities.Here, we...
The objective was to obtain a standardized evaluation of available prostate cancer-specific quality life instruments used in patients with early-stage disease.We carried out systematic literature reviews the PubMed database identify manuscripts which contained information regarding either development process or metric properties instruments. Each instrument evaluated by two experts, independently, using Evaluating Measures Patient-Reported Outcomes (EMPRO) tool. An overall and seven...
The transcriptional regulator BRD4 has been shown to be important for the expression of several oncogenes including MYC. Inhibiting broad antiproliferative activity in different cancer cell types. small molecule JQ1 blocks interaction with acetylated histones leading modulation. Depleting via engineered bifunctional molecules named PROTACs (proteolysis targeting chimeras) represents next-generation approach JQ1-mediated inhibition. trigger proteasomale degradation by recruiting E3 ligases....
Abstract Anti-CD3 x anti-tumor-bispecific Abs have been used to redirect cytotoxic T cells tumor in an MHC-unrestricted fashion and induce their rejection vivo. We recently described a recombinant bispecific single-chain Ab that combines four different V regions of two Abs, anti-17-1A anti-CD3, on one polypeptide chain. It folds correctly 60-kDa globular protein is secreted fully functional form by high producer Chinese hamster ovary cell line. In this work, we report its remarkable...
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Protein synthesis is an essential process, deregulated in multiple tumor types showing differential dependence on translation factors compared to untransformed tissue. We show that colorectal cancer (CRC) with loss-of-function mutation the APC suppressor depends oncogenic program regulated by ability sense phosphorylated eIF2α (p-eIF2α). Despite increased protein rates following loss, phosphorylation, typically associated inhibition, enhanced CRC. Elevated p-eIF2α, and its proper sensing...
Background: ESR1 mutations are biomarkers in breast cancer patients who develop metastatic disease after endocrine therapy (ET). Recently, the Food and Drug Administration (FDA) European Medicines Agency (EMA) have approved Elacestrant, a selective estrogen receptor degrader for harboring mutations. This has necessitated establishment of reliable sensitive NGS- or PCR-based assays to detect these resistance liquid biopsy samples. Methods: We evaluated NGS results pan-cancer cohort almost...
Fixed‐dose combinations (FDC) have been developed to reduce the pill burden for hypertensive patients. Data on fixed‐dose or free‐dose (freeDC) ramipril/amlodipine (R/A) candesartan/amlodipine (C/A) combination treatment initiation were assessed. 71 463 patients prescribed R/A and 10 495 C/A. For both C/A, FDC younger (both P < .001) less comorbid. Prior MI (OR: 0.61 0.60), prior stroke 0.68 0.70) CHD 0.64) negatively associated with use, whereas hyperlipidemia was positively 1.26 1.19)....
The Melan-Aaa26–35 (EAAGIGILTV) peptide is a human leukocyte antigen (HLA)-A2-restricted T-cell epitope within the Melan-A/MART-1 tumor expressed on malignant melanoma cells. Melan-A and analog (ELAGIGILTV, Melan-Aaa26–35*A27L) specific T-cells can be expanded reliably for immunotherapeutic approaches in vitro. We studied ability of to recognize HM1.24aa22−30 (LLLGIGILV) HM1.24 presented by normal plasma Peripheral blood mononuclear cells from HLA-A2+ healthy donors multiple myeloma (MM)...
Abstract The evolutionarily conserved proteins REI1-LIKE (REIL1) and REIL2 have four zinc finger domains are Arabidopsis thaliana homologs of the cytosolic 60S ribosomal maturation factor Rei1p (for Required for isotropic bud growth1 protein) from yeast (Saccharomyces cerevisiae) its paralog Reh1p REI1 homologue1 protein). A. paralogs result independent gene duplications. REIL required specifically in cold (10°C) but not growth at optimal temperature (20°C). A reil1-1 reil2-1 double mutant...
Multiple myeloma is a common plasma-cell-derived hematologic neoplasm. While the delivery of growth-inhibiting miRNA to multiple cells would be promising strategy evaluate treatment options, most are transfection-resistant with established methods. Nonviral nanoparticulate transfection systems particularly in this context, but so far struggle and knockdown efficiency. Here, we present poly(glycidol)-based nanogels covalently bound cell-penetrating peptide TAT (transactivator transcription...
The regulatory protein pUL69 of human cytomegalovirus acts as a viral mRNA export factor, facilitating the cytoplasmic accumulation unspliced RNA via interaction with cellular factor UAP56. Here we provide evidence for posttranslational modification arginine methylation within functionally important N terminus. First, demonstrated specific immunoprecipitation full-length well pUL69aa1-146 by mono/dimethylarginine-specific antibody. Second, observed electrophoretic mobility shift upon...