A5017946671- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Invertebrate Immune Response Mechanisms
- Physiological and biochemical adaptations
- Hippo pathway signaling and YAP/TAZ
- Developmental Biology and Gene Regulation
- Plant Molecular Biology Research
- CRISPR and Genetic Engineering
- Genetics and Physical Performance
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Plant Reproductive Biology
- Advanced Fluorescence Microscopy Techniques
- Insect Utilization and Effects
- Olfactory and Sensory Function Studies
- Marine Ecology and Invasive Species
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Microtubule and mitosis dynamics
- Lipid metabolism and biosynthesis
- Trypanosoma species research and implications
- Circadian rhythm and melatonin
Theories and Approaches of Genomic Complexity
2021-2024
Inserm
1996-2024
Institut de Biologie Valrose
1996-2014
Université Côte d'Azur
2006-2014
Centre National de la Recherche Scientifique
1996-2014
Centre Antoine Lacassagne
2004-2005
Centre de Biologie du Développement
2004
Institut de Biologie du Développement Marseille
1996-2001
Laboratoire Génome et Développement des Plantes
1998
Insulin signaling is a conserved feature in all metazoans. It evolved with the appearance of multicellularity, allowing primordial metazoans to respond greater diversity environmental signals. The insulin pathway highly insects and particularly Drosophila, where it has been extensively studied recent years shown control metabolism, growth, reproduction, longevity. Because misregulation insulin/IGF humans plays role many medical disorders, such as diabetes various types cancer, unraveling...
ABSTRACT Inactivation of the lethal(2)giant larvae (l(2)gl) gene results in malignant transformation imaginal disc cells and neuroblasts larval brain Drosophila. Subcellular localization l(2)gl product, P127, its biochemical characterization have indicated that it participates formation cytoskeletal network. In this paper, genetic phenotypic analyses a temperaturesensitive mutation (l(2)glts3) behaves as hypomorphic allele at restrictive temperature are presented. experimentally overaged...
ABSTRACT This article describes the characterization of a new Drosophila gene that we have called pitchoune (pit) (meaning small in Provence) because mutations this produce larvae cannot grow beyond first instar larval stage although they can live as long 7-10 days. All tissues are equally affected and perfectly shaped indistinguishable from wild-type animals. Analysis mutant somatic clones suggests function cell growth proliferation, which is supported by fact proliferation promoted pit...
The mechanism by which hypoxia induces gene transcription involves the inhibition of HIF-1α (hypoxia-inducible factor-1 α subunit) PHD (prolyl hydroxylase) activity, prevents VHL (von Hippel-Lindau)-dependent targeting to ubiquitin/proteasome pathway. thus accumulates and promotes transcription. In present study, first we provide direct biochemical evidence for presence a conserved hypoxic signalling pathway in Drosophila melanogaster. An assay 2-oxoglutarate-dependent dioxygenases was...
The Drosophila tumor suppressor gene lethal(2) giant larvae (lgl) encodes a cytoskeletal protein required for the change in shape and polarity acquisition of epithelial cells, also asymmetric division neuroblasts. We show here that lgl participates emission Decapentaplegic (Dpp), member transforming growth factor β (TGFβ) family, various developmental processes. During embryogenesis, is dpp-dependent transcriptional activation zipper (zip), which non-muscle myosin heavy chain (NMHC),...
Abstract The brain plays a key role in energy homeostasis, detecting nutrients, metabolites and circulating hormones from peripheral organs integrating this information to control food intake expenditure. Here, we show that group of neurons the Drosophila larval expresses adiponectin receptor (AdipoR) controls systemic growth metabolism through insulin signaling. We identify glucose-regulated protein 78 (Grp78) as antagonist AdipoR function produced by fat cells response dietary sugar....
Summary The identification of genetic factors influencing cardiac senescence in natural populations is central to our understanding aging and identify the etiology associated disorders human populations. However, underpinning complex traits almost impossible, due infeasibility control background gene-environment interactions. Drosophila has striking similarities with humans, highlighting conserved nature for organisms a heart. Leveraging on large collection inbred lines from Genetic...
SUMMARY Cardiopathies are one of the leading causes death in obese diabetics. Resulting part from junk food, diabetic cardiomyopathies notably characterized by contractile dysfunctions. Using Drosophila model for cardiac function pathophysiological context, we identified a set candidate genes, expressed heart, whose expression is modulated acute challenge on High Sugar and Fat regimes. Genes encoding core components key homeostatic pathways proteins such as 1C-metabolism homeostasis,...
Des experiences recentes realisees sur la drosophile montrent que stimulation des divisions cellulaires ne conduit pas a une augmentation de masse tissulaire. L'inhibition ou l'induction proliferation entraine formation tissus meme taille avec, respectivement, cellules anormalement grosses exceptionnellement petites. Ces donnees indiquent, par ailleurs, croissance est dominante et limitante proliferation. Cet eclairage nouveau liens entre cellulaire (augmentation masse) du nombre cellules)...