A5091748182- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Physiological and biochemical adaptations
- Cardiomyopathy and Myosin Studies
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
- Genetic Associations and Epidemiology
- Scientific Computing and Data Management
- Congenital heart defects research
- Mitochondrial Function and Pathology
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Distributed and Parallel Computing Systems
- Genetic and phenotypic traits in livestock
- Ubiquitin and proteasome pathways
- Trypanosoma species research and implications
- Viral Infectious Diseases and Gene Expression in Insects
- Studies on Chitinases and Chitosanases
- Protein Kinase Regulation and GTPase Signaling
- Vibrio bacteria research studies
Inserm
2014-2024
Theories and Approaches of Genomic Complexity
2016-2024
Aix-Marseille Université
2012-2022
Institut de Biologie du Développement Marseille
1999-2004
Centre National de la Recherche Scientifique
1991-1997
Laboratoire de Génétique Cellulaire
1992
Centre d’Immunologie de Marseille-Luminy
1991-1992
Laboratoire de génétique et biologie cellulaire
1992
Flynets (http://gifts.univ-mrs.fr/FlyNets/FlyNets_home_page.html) is a WWW database describing molecular interactions (protein-DNA, protein-RNA and protein-protein) in the fly Drosophila melanogaster. It composed of two parts, as follows. (i) FlyNets-base specialized which focuses on involved development. The information content distributed among several specific lines arranged according to GenBank-like format grouped into five thematic zones improve human readability. FlyNets achieves high...
ABSTRACT The phenotypes of different mutant combinations teashirt (tsh) and homeotic genes together with their regulatory interactions are described in order to gain insight into tsh gene function. We show that when tsh, Scr, Antp BX-C missing, the ventral part trunk (or thorax abdomen) is transformed anterior head identity showing a gene. These act synergistically suppress expression procephalic labial (lab) subsets cells each segment trunk. Transcripts from always accumulate segments...
The rotund (rn) locus of Drosophila melanogaster at cytogenetic position 84D3,4 has been isolated and cloned on the basis mutant phenotype: an absence structures in subdistal regions appendages. shortened appendages are consequence a localized cell death imaginal discs, precursors adult Physical characterization rn demonstrated that it is relatively large, occupying minimum 50 kb. There two major transcripts 1.7 kb (m1.7) 5.3 (m5.3). We present here sequence analysis m1.7 its putative...
Abstract Understanding the relationship between genetic variations and in complex quantitative phenotypes remains an ongoing challenge. While Genome-wide association studies (GWAS) have become a vital tool for identifying single-locus associations, we lack methods epistatic interactions. In this article, propose novel method higher-order epistasis detection using mixed effect conditional inference forest (epiMEIF). The proposed is fitted on group of single nucleotide polymorphisms (SNPs)...
Deciphering the genetic architecture of human cardiac disorders is fundamental importance but their underlying complexity a major hurdle. We investigated natural variation performance in sequenced inbred lines Drosophila Genetic Reference Panel (DGRP). Genome-wide associations studies (GWAS) identified networks associated with traits which were used to gain insights as molecular and cellular processes affected. Non-coding variants that we map potential regulatory non-coding regions, turn...
Abstract In mammals, both sterile wounding and infection induce inflammation activate the innate immune system, combination of challenges may lead to severe health defects, revealing importance balance between intensity resolution inflammatory response for organism’s fitness. Underlying mechanisms remain however elusive. Using Drosophila, we show that, upon with entomopathogenic bacterium Pseudomonas entomophila (Pe) , a induces reduced resistance increased host mortality. To identify...
Developmental patterning and tissue formation are regulated through complex gene regulatory networks (GRNs) driven the action of transcription factors (TFs) converging on enhancer elements. Here, as a point entry to dissect poorly defined GRN underlying cardiomyocyte differentiation, we apply an integrated approach identify active enhancers TFs involved in Drosophila heart development. The consists 104 cardiomyocytes, representing less than 0.5% all cells embryo. By modifying BiTS-ChIP for...
Mutations in the MYBPC3 gene encoding human cardiac myosin-binding protein-C (cMyBP-C) are associated with familial hypertrophic cardiomyopathy (FHC), but molecular mechanisms involved not fully understood. In addition, development of FHC is sensitive to genetic background, and search for candidate modifier genes crucial a view proposing diagnosis exploring new therapies. We used Drosophila as model investigate vivo consequences cMyBP-C mutations. first produced transgenic flies that...
GIF-DB (Gene Interactions in the Fly Database) is a new WWW database (http://www-biol.univ-mrs.fr/ approximately lgpd/GIFTS_home_page. html ) describing gene molecular interactions involved process of embryonic pattern formation flyDrosophila melanogaster. The detailed information distributed specific lines arranged into an EMBL- (or SWISS-PROT-) like format. achieves high level integration with other databases such as FlyBase, EMBL and SWISS-PROT through numerous hyperlinks. original...
Summary The identification of genetic factors influencing cardiac senescence in natural populations is central to our understanding aging and identify the etiology associated disorders human populations. However, underpinning complex traits almost impossible, due infeasibility control background gene-environment interactions. Drosophila has striking similarities with humans, highlighting conserved nature for organisms a heart. Leveraging on large collection inbred lines from Genetic...
SUMMARY Cardiopathies are one of the leading causes death in obese diabetics. Resulting part from junk food, diabetic cardiomyopathies notably characterized by contractile dysfunctions. Using Drosophila model for cardiac function pathophysiological context, we identified a set candidate genes, expressed heart, whose expression is modulated acute challenge on High Sugar and Fat regimes. Genes encoding core components key homeostatic pathways proteins such as 1C-metabolism homeostasis,...
Abstract Deciphering the genetic architecture of human cardiac disorders is fundamental importance but their underlying complexity a major hurdle. We investigated natural variation performance in sequenced inbred lines Drosophila Genetic Reference Panel (DGRP). Genome Wide Associations Studies (GWAS) identified networks associated with traits which were used to gain insights as molecular and cellular processes affected. Non-coding variants that we map potential regulatory non-coding regions,...
Sepsis is a complex and heterogeneous syndrome in which inflammatory infection mechanisms are implicated. Thus, it difficult to differentiate those mammals where inflammation highly biological process. In our laboratory, besides studying sepsis human blood samples, we choose investigate murine model ordered describe global transcriptome overview of critical events occurring the blood, brain lung during an induced non-infection inflammation. We decided complete view with another animal...
The rotund (rn) locus of Drosophila melanogaster at cytogenetic position 84D3,4 has been isolated and cloned on the basis mutant phenotype: an absence structures in subdistal regions appendages. shortened appendages are consequence a localized cell death imaginal discs, precursors adult Physical characterization rn demonstrated that it is relatively large, occupying minimum 50 kb. There two major transcripts 1.7 kb (m1.7) 5.3 (m5.3). We present here sequence analysis m1.7 its putative...