A5033538139- Fusion materials and technologies
- Genomics and Chromatin Dynamics
- SARS-CoV-2 and COVID-19 Research
- Nuclear Materials and Properties
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Metal and Thin Film Mechanics
- Sepsis Diagnosis and Treatment
- Plant Molecular Biology Research
- Poxvirus research and outbreaks
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Mycorrhizal Fungi and Plant Interactions
- Mosquito-borne diseases and control
- RNA Research and Splicing
- Immune Response and Inflammation
- Immune cells in cancer
- Computational Drug Discovery Methods
- Cardiac Health and Mental Health
- Neutropenia and Cancer Infections
- Fibroblast Growth Factor Research
- Ion-surface interactions and analysis
- Advanced Physical and Chemical Molecular Interactions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Inserm
2015-2025
Université de Montpellier
2021-2025
Institut de Recherche pour le Développement
2021-2025
Theories and Approaches of Genomic Complexity
2015-2022
Aix-Marseille Université
2012-2021
University of New Caledonia
2019-2021
Physique des interactions ioniques et moléculaires
2016
Laboratoire de Neurosciences Intégratives et Adaptatives
2016
Centre National de la Recherche Scientifique
2012-2015
Yeshiva University
2009
Cell-type specific regulation of gene expression requires the activation promoters by distal genomic elements defined as enhancers. The identification and characterization enhancers are challenging in mammals due to their genome complexity. Here we develop CapStarr-Seq, a novel high-throughput strategy quantitatively assess enhancer activity mammals. This approach couples capture regions interest previously developed Starr-seq technique. Extensive assessment CapStarr-seq demonstrates...
ABSTRACT Background Recent reports raise concerns on the changing epidemiology of mpox in Democratic Republic Congo (DRC), with increasing case counts, sexual contact-mediated clusters, and sustained human-to-human transmission driven by a novel monkeypox virus (MPXV) subclade, clade Ib. However, only limited number I MPXV genomes have been characterized so far, from regions. Methods We conducted whole genome sequencing 603 mpox-positive samples that were collected 581 patients between...
Abstract Background Several variants of SARS-CoV-2 have a demonstrated impact on public health, including high and increased transmissibility, severity infection, immune escape. Therefore, this study aimed to determine the lineages better characterize dynamics pandemic during different waves in Guinea. Methods Whole genome sequencing 363 samples with PCR cycle threshold (Ct) values under thirty was undertaken between May 2020 2023. The Illumina iSeq 100 technology used. sequences were then...
Density Functional Theory studies show that in tungsten a mono vacancy can contain up to 6 Hydrogen Isotopes (HIs) at 300K with detrapping energies varying the number of HIs vacancy.Using these predictions, multi trapping rate equation model has been built and used thermal desorption spectrometry (TDS) experiments performed on single crystal after deuterium ions implantation.Detrapping obtained from adjust temperature TDS spectrum observed experimentally are good agreement DFT values within...
Major depressive disorder (MDD) is a highly prevalent mental illness whose therapies management remains uncertain, with more than 20% of patients who do not achieve response to antidepressants. Therefore, identification reliable biomarkers predict treatment will greatly improve MDD patient medical care. Due the inaccessibility and lack brain tissues from living study depression, researches using animal models have been useful in improving sensitivity specificity identifying biomarkers. In...
Human Mpox cases are increasingly reported in Africa, with the highest burden Democratic Republic of Congo (DRC). While case reporting on a clinical basis can overestimate infection rates, laboratory confirmation by PCR underestimate them, especially suboptimal samples like blood, commonly used DRC. Here we Luminex-based assay to evaluate whether antibody testing be complementary confirm and identify human transmission chains during outbreak investigations. We left-over blood from 463...
Mortality due to sepsis remains unacceptably high, especially for septic shock patients. Murine models have been used better understand pathophysiology mechanisms. However, the mouse model is still under debate. Herein we investigated transcriptional response of mice injected with lipopolysaccharide (LPS) and compared it either human cells stimulated in vitro LPS or blood We identified a molecular signature composed 2331 genes an FDR median 0%. This highly enriched regulated peritoneal...
In this paper, we combine density functional theory data with a thermodynamic and kinetic model to determine the total concentration of hydrogen implanted in subsurface tungsten exposed flux. The is calculated given flux hydrogen, temperature implantation, energy incoming ions as independent variables. This global built step by step; an equilibrium between atomic within bulk molecular gas phase first considered, solubility compared experimental results. Subsequently, used chemical potential...
Due to their central role in ecosystems functioning and ability rapidly respond environmental changes, soil microorganisms could potentially be used for monitoring recovery the context of degraded land restoration. However, these belowground organisms have been, date, largely neglected. Here, we investigated fungal bacterial community diversity, composition, structure from ultramafic soils New Caledonia, an archipelago southwest Pacific recognized as a priority conservation The emerging...
Abstract Background Plasmodium falciparum malaria remains a major health problem in Africa. The mechanisms of pathogenesis are not fully understood. Transcriptomic studies may provide new insights into molecular pathways involved the severe form disease. Methods Blood transcriptional levels were assessed patients with cerebral malaria, non-cerebral or mild by using microarray technology to look for gene expression profiles associated clinical status. Multi-way ANOVA was used extract...
The interaction of beryllium with benzene, graphene and graphitic compounds involves multi-reference electronic states, Jahn-Teller distortion, charge transfer van der Waals interactions. This is investigated herein using periodic molecular models at different levels theory: (i) the second-order Møller-Plesset (MP2) perturbation theory, (ii) coupled cluster method inclusion single double perturbative triple excitations (CCSD(T)), (iii) complete active space self-consistent field (CAS-SCF)...
Our previous transcriptomic analysis of Glossina palpalis gambiensis experimentally infected or not with Trypanosoma brucei gambiense aimed to detect differentially expressed genes (DEGs) associated infection. Specifically, we selected candidate governing tsetse fly vector competence that could be used in the context an anti-vector strategy, control human and/or animal trypanosomiasis. The present study verify whether gene expression field flies (G. p. palpalis) is modified response natural...
Abstract In mammals, both sterile wounding and infection induce inflammation activate the innate immune system, combination of challenges may lead to severe health defects, revealing importance balance between intensity resolution inflammatory response for organism’s fitness. Underlying mechanisms remain however elusive. Using Drosophila, we show that, upon with entomopathogenic bacterium Pseudomonas entomophila (Pe) , a induces reduced resistance increased host mortality. To identify...
Tight regulation of kinetochore microtubule dynamics is required to generate the appropriate position and movement chromosomes on mitotic spindle. A widely studied but mysterious aspect this occurs during metaphase when polymerization plus-ends balanced by depolymerization at their minus-ends. Thus, microtubules maintain a constant net length, allowing persist spindle equator, consist tubulin subunits that continually flux toward poles. Here, we construct feasible network regulatory proteins...
Traumatic brain injury (TBI) is associated with a collection of physical, emotional and cognitive post complications. The background for such complex consequences may be due to number different factors, the nature these changes indicates that frontal lobes implicated. In this study we have employed gene expression arrays ontology databases search possible similarities between forms acquired injuries in order test whether molecular relationships exist pathologies. Two types experimental...
The purpose of this paper is the characterization a plasma-doping system in BF3. Energy distributions (IEDs) boron ions crossing high-voltage sheath (up to 1 kV) are measured BF3 plasma under different experimental conditions. It demonstrated that relative percentages reaching cathode and IED shapes governed by number collisions inside sheath. Heavy molecular , dissociated light (B+, BF+) created. Based on results ab initio calculations ion structures, mechanisms occurring discussed....