A5051618172- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Herpesvirus Infections and Treatments
- Vaccine Coverage and Hesitancy
- Virology and Viral Diseases
- Viral Infections and Vectors
- Zoonotic diseases and public health
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Disaster Response and Management
- Viral Infections and Immunology Research
- Rabies epidemiology and control
- Immune responses and vaccinations
- Streptococcal Infections and Treatments
- Animal Disease Management and Epidemiology
- Hepatitis B Virus Studies
- Antimicrobial Resistance in Staphylococcus
- Infection Control and Ventilation
- Yersinia bacterium, plague, ectoparasites research
- HIV Research and Treatment
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- COVID-19 and Mental Health
University of California, Los Angeles
2013-2025
UCLA Health
2010-2025
Fielding Graduate University
2017-2025
University of Kinshasa
2018-2024
National Institute of Biomedical Research
2017-2024
Clinical Research Consortium
2024
AID Atlanta
2024
University of California, Irvine
2023
Research Center Borstel - Leibniz Lung Center
2023
Centers for Disease Control and Prevention
2023
Studies on the burden of human monkeypox in Democratic Republic Congo (DRC) were last conducted from 1981 to 1986. Since then, population that is immunologically naïve orthopoxviruses has increased significantly due cessation mass smallpox vaccination campaigns. To assess current risk infection, we analyzed incidence trends a monkeypox-enzootic region. Active, population-based surveillance was nine health zones central DRC. Epidemiologic data and biological samples obtained suspected cases....
Human monkeypox is an endemic disease in rain-forested regions of central Democratic Republic Congo. We report fetal outcomes for 1 4 pregnant women who participated observational study at the General Hospital Kole (Sankuru Province), where 222 symptomatic subjects were followed between 2007 and 2011. Of women, gave birth to a healthy infant, 2 had miscarriages first trimester, death, with macerated stillborn showing diffuse cutaneous maculopapillary skin lesions involving head, trunk...
Abstract Monkeypox virus is a zoonotic endemic to Central Africa. Although active disease surveillance has assessed monkeypox prevalence and geographic range, information about diversity lacking. We therefore genome of viruses in 60 samples obtained from humans with primary secondary cases infection 2005 through 2007. detected 4 distinct lineages deletion that resulted gene loss 10 (16.7%) seemed correlate human-to-human transmission (p = 0.0544). The data suggest high frequency spillover...
Smallpox eradication, coordinated by the WHO and certified 40 years ago, led to cessation of routine smallpox vaccination in most countries. It is estimated that over 70% world's population no longer protected against smallpox, through cross-immunity, closely related orthopox viruses such as monkeypox. Monkeypox now a re-emerging disease. endemic yet unconfirmed animal reservoirs sub-Saharan Africa, while its human epidemiology appears be changing. small animals imported from Ghana exotic...
The science around the use of masks by general public to impede COVID-19 transmission is advancing rapidly. Policymakers need guidance on how should be used population combat pandemic. Here, we synthesize relevant literature inform multiple areas: 1) characteristics COVID-19, 2) filtering and efficacy masks, 3) estimated impacts widespread community mask use, 4) sociological considerations for policies concerning mask-wearing. A primary route likely via small respiratory droplets, known...
Letters9 February 2021Cross-sectional Assessment of COVID-19 Vaccine Acceptance Among Health Care Workers in Los AngelesFREEAdva Gadoth, MPH, PhD*, Megan Halbrook, MPH*, Rachel Martin-Blais, MD, Ashley Gray, Nicole H. Tobin, Kathie G. Ferbas, PhD, Grace M. Aldrovandi, MD†, Anne W. Rimoin, PhD†Adva PhD*Jonathan and Karin Fielding School Public Health, University California, Angeles, CaliforniaSearch for more papers by this author, MPH*Jonathan MDDavid Geffen Medicine at PhDDavid MD†David...
Outbreaks of monkeypox (mpox) have historically resulted from zoonotic spillover clade I virus (MPXV) in Central Africa and II MPXV West Africa. In 2022, subclade IIb caused a global epidemic linked to transmission through sexual contact. Here we describe the epidemiological genomic features an mpox outbreak mining region eastern Democratic Republic Congo, by MPXV. Surveillance data collected between September 2023 January 2024 identified 241 suspected cases. Genomic analysis demonstrates...
We report a cluster of clade I monkeypox virus infections linked to sexual contact in the Democratic Republic Congo. Case investigations resulted 5 reverse transcription PCR-confirmed infections; genome sequencing suggest they belonged same transmission chain. This finding demonstrates that mpox through extends beyond IIb.
ABSTRACT Background Monkeypox virus (MPXV) attracted global attention in 2022 during a widespread outbreak linked primarily to sexual contact. Clade I MPXV is prevalent Central Africa and characterized by severe disease high mortality, while II confined West associated with milder illness. A IIb emerged Nigeria 2017, protracted human-to-human transmission forerunner of the B.1 lineage 2022. In October 2023, large mpox Kamituga mining region Democratic Republic Congo (DRC), which we conducted...
Mpox was previously thought to be a zoonotic disease endemic in parts of central, west, and east Africa; however, from 2022 2023, large global outbreak mpox clade II monkeypox virus occurred, marking the first instance sustained transmission outside Africa since case human identified 1970.1WHOMonkeypox – United Kingdom Great Britain Northern Ireland.https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON383Date: May 18, 2022Date accessed: March 24, 2024Google Scholar More...
Recent reports raise concerns on the changing epidemiology of mpox in Democratic Republic Congo (DRC). High-quality genomes were generated for 337 patients from 14/26 provinces to document whether increase number cases is due zoonotic spillover events or viral evolution, with enrichment APOBEC3 mutations linked human adaptation. Our study highlights two patterns transmission contributing source cases. All new sequences eastern South Kivu province (n = 17; 4.8%) corresponded recently...
Deep sequencing was used to discover a novel rhabdovirus (Bas-Congo virus, or BASV) associated with 2009 outbreak of 3 human cases acute hemorrhagic fever in Mangala village, Democratic Republic Congo (DRC), Africa. The cases, presenting over 3-week period, were characterized by abrupt disease onset, high fever, mucosal hemorrhage, and, two patients, death within days. BASV detected an serum sample from the lone survivor at concentration 1.09×106 RNA copies/mL, and 98.2% genome subsequently...
By analyzing vesicle fluids and crusted scabs from 136 persons with suspected monkeypox, we identified 51 cases of monkeypox by PCR, sequenced the hemagglutinin gene, confirmed 94% virus culture. PCR demonstrated chickenpox in 61 patients. Coinfection both viruses was found 1 additional patient.
The newly identified coronavirus, COVID-19, was first reported in Wuhan, China on December 31, 2019. In one month, cases outnumber those from the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) epidemic [[1]Wu J.T. Leung K. G.M. Nowcasting and forecasting potential domestic international spread of 2019-nCoV outbreak originating China: a modelling study.Lancet. 2020; (Published online ahead print.)https://doi.org/10.1016/S0140-6736(20)30260-9Summary Full Text PDF Scopus (2827) Google...
The science around the use of masks by general public to impede COVID-19 transmission is advancing rapidly. Policymakers need guidance on how should be used population combat pandemic. In this narrative review, we develop an analytical framework examine mask usage, considering and synthesizing relevant literature inform multiple areas: impact; characteristics; source control; PPE; sociological considerations; implementation considerations. A primary route via respiratory droplets, known...
Abstract Importance Healthcare workers (HCW) are slated to be early recipients of SARS-CoV-2 vaccines due increased risk exposure patients with COVID-19, and will tasked administering approved the general population. As lynchpins vaccination effort, HCWs’ opinions a vaccine’s safety efficacy may affect both public perception uptake vaccine. Therefore, it is crucial understand address potential hesitancy prior vaccine administration. Objective To healthcare workers’ attitudes about safety,...
During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province Democratic Republic of Congo, EVD was diagnosed a patient who had received recombinant vesicular stomatitis virus-based vaccine expressing ZEBOV glycoprotein (rVSV-ZEBOV) (Merck).His treatment included an (EBOV)-specific monoclonal antibody (mAb114), and he recovered within 14 days.However, 6 months later, presented again with severe EVD-like illness EBOV viremia, died.We initiated epidemiologic genomic...
Studies of two SARS-CoV-2 mRNA vaccines suggested that they yield ∼95% protection from symptomatic infection at least short-term, but important clinical questions remain. It is unclear how vaccine-induced antibody levels quantitatively compare to the wide spectrum induced by natural infection. Vaccine response kinetics and magnitudes in persons with prior COVID-19 compared virus-naı̈ve are not well-defined. The relative stability versus infection-induced unclear. We addressed these issues...
The national census is an essential data source to support decision-making in many areas of public interest. However, this may become outdated during the intercensal period, which can stretch up several decades. We developed a Bayesian hierarchical model leveraging recent household surveys with probabilistic sampling designs and building footprints produce up-to-date population estimates. estimated totals age sex breakdowns associated uncertainty measures within grid cells approximately 100m...