A5100683865- Birth, Development, and Health
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Sexual function and dysfunction studies
- Growth Hormone and Insulin-like Growth Factors
- Obesity, Physical Activity, Diet
- Colorectal Cancer Surgical Treatments
- Gestational Diabetes Research and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Gestational Trophoblastic Disease Studies
- Prenatal Screening and Diagnostics
- Lipid metabolism and disorders
- Helicobacter pylori-related gastroenterology studies
- Congenital Diaphragmatic Hernia Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Regulation of Appetite and Obesity
- Pregnancy and preeclampsia studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Fibrosis and Remodeling
- Sexuality, Behavior, and Technology
- Nutrition and Health in Aging
First Affiliated Hospital Zhejiang University
2017-2025
Southern Medical University
2014-2025
Nanfang Hospital
2014-2025
Harbin Medical University
2021-2024
Second Affiliated Hospital of Harbin Medical University
2021-2024
Guiyang Medical University
2019-2024
Anhui and Huaihe River Institute of Hydraulic Research
2024
Yunnan Normal University
2024
Third Affiliated Hospital of Sun Yat-sen University
2023-2024
Sun Yat-sen University
2023-2024
Deep sequencing was used to discover a novel rhabdovirus (Bas-Congo virus, or BASV) associated with 2009 outbreak of 3 human cases acute hemorrhagic fever in Mangala village, Democratic Republic Congo (DRC), Africa. The cases, presenting over 3-week period, were characterized by abrupt disease onset, high fever, mucosal hemorrhage, and, two patients, death within days. BASV detected an serum sample from the lone survivor at concentration 1.09×106 RNA copies/mL, and 98.2% genome subsequently...
Using viral metagenomics of brain tissue from a young adult crossbreed steer with acute onset neurologic disease, we sequenced the complete genome novel astrovirus (BoAstV-NeuroS1) that was phylogenetically related to an ovine astrovirus. In retrospective analysis 32 cases bovine encephalitides unknown etiology, 3 other infected animals were detected by using PCR and in situ hybridization for RNA. Viral RNA restricted nervous system cytoplasm affected neurons within spinal cord, brainstem,...
AIM:To investigate the effect of lifestyle intervention on non-alcoholic fatty liver disease (NAFLD) in Chinese obese children. METHODS:Seventy-six children aged from 10 to 17 years with NAFLD were enrolled for a one-month and divided randomly into three groups.Group1, consisting 38 children, was an untreated control group without any intervention.Group 2, 19 summer camp, strictly controlled only by life style 3, received oral vitamin E therapy at dose 100 mg/d.The height, weight, fasting...
To identify rare allelic variants and HLA alleles in narcolepsy patients with hypocretin (orexin, HCRT) deficiency but lacking DQB1*06:02.China (Peking University People's Hospital), Czech Republic (Charles University), Denmark (Golstrup Italy (University of Bologna), Korea (Catholic USA (Stanford University).CSF hypocretin-1, DQB1*06:02, clinical polysomnographic data were collected (552 144 without cataplexy) from 6 sites. Numbers cases DQB1*06:02 low CSF hypocretin-1 compiled. class I (A,...
Many single nucleotide polymorphisms (SNPs) have been found to be associated with breast cancer, but their SNP interactions are seldom addressed. In this study, we focused on the joint effect for combinations of seven CXCL12-related genes involved in major cancer-related pathways. genotyping was determined by PCR-restriction fragment length polymorphism (RFLP) study (case = 220, control 334). Different numbers combinational SNPs genotypes called barcodes from different chromosomes were used...
Long-term fine particulate matter (PM2.5) exposure was associated with childhood obesity. However, the key PM2.5 components and whether effect may vary by obesity type, growth stage, sex, individual/family characteristics have yet been examined. In this study, we investigated 213,907 Chinese children adolescents aged 3-18 years in 2017-2019. Three-year average concentrations of five major were assigned to each participant's address. Multivariable mixed-effects model weighted quantile sum...
166 Background: Maintenance therapy with bevacizumab (Bev) plus capecitabine (Cap) is widely recommended to unresectable mCRC patients (pts). Fruquintinib (Fru) a highly selective TKI that inhibits vascular endothelial growth factor receptor (VEGFR)-1,2,3. This study compare the therapeutic potential of alternating treatment fruquintinib and as maintenance for (NCT05659290). Methods: Eligible pts aged 18-75 years stable disease or better after induction chemotherapy in combination Bev, ECOG...
Background: Premature ejaculation (PE) is a largely prevalent sexual complaint that can lead to distress in couple relationships and significantly reduce patients’ quality of life. Despite the considerable progress PE research last decades, there still lack visual summarized literature for comprehensive understanding. Objective: This study aims identify collaboration patterns among different authors, countries, institutions explore hotspots prospects field. Methods: On January 22, 2024, we...
Abstract Context Age of pubertal onset has been decreasing in many countries but there have no data on development Chinese children over the last decade. Objective The primary objective study was to evaluate current status sexual maturation and adolescents. Secondary objectives were examine socioeconomic, lifestyle, auxological associations with onset. Methods In this national, cross-sectional, community-based health survey, a multistage, stratified cluster random sampling method used select...
Wiskott-Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the WAS gene, which together with its homolog, N-WASP, regulates actin cytoskeleton remodeling and cell motility. patients suffer from microthrombocytopenia, characterized diminished number size of platelets, though underlying mechanism not fully understood. Here, we identified FLI1 as direct transcriptional regulator binding partner WIP. Depletion either or WIP human erythroleukemic...
Cardiac septal overgrowth complicates 10–40% of births from diabetic mothers, but perplexingly hyperglycemia markers during pregnancy are not reliably predictive. We thus tested whether fetal exposure to is sufficient induce cardiac even in the absence systemic maternal diabetes. To isolate effects hyperglycemia, we infused glucose into blood supply left right uterine horn nondiabetic pregnant rats starting on gestational day 19. After 24 h infusion, right-sided fetuses and dams remained...
Microtubule-associated protein light chain 3 (LC3A) is a reliable marker of autophagy that displays three distinct patterns immunohistochemical staining in solid tumors: diffuse cytoplasmic staining, juxtanuclear and "stone-like" structures. These have different prognostic significance many tumors, but little known about their influence gastric cancer (GC). This study was retrospective analysis 188 GC patients from stages I to IV. The pattern LC3A expression examined tumor nontumor tissues...
The relationship between birth weight and blood pressure has not been well explored in Chinese children adolescents. aim of this study was to investigate the childhood China. A total 15324 adolescents (7919 boys 7405 girls) aged 7–17 years were stratified into six groups. Analysis covariance binary logistic regression used analyse while controlling for potential confounding factors, including age, gestational season area residence. group with weights from 2500 2999 g had lowest prevalence...
ADAM10 is a metalloproteinase that regulates invasiveness in many tumors. Here, we found expression correlates with the of pituitary adenomas and contributes to invasion by cleaving L1 CD44. In high-grade adenoma patients, levels were be elevated compared low-grade adenomas. phorbol 12-myristate 13-acetate (PMA)-stimulated cell line, AtT-20 cells, cleavage was correspondingly enhanced increased interaction between Src Shc. Increases PMA-induced phosphorylation residue 418 (418Src) promoted...
Objective This study aimed to compare survival and toxicity between induction chemotherapy followed by concurrent chemoradiotherapy (IC + CCRT) (CCRT) alone in elderly patients with advanced nasopharyngeal carcinoma (NPC). Study Design Propensity‐matched analysis of a retrospective cohort. Setting Department Medical Oncology, Jingzhou Hospital, Tongji College, Huazhong University Science Technology, China. Subjects Methods In total, 193 stage III IVb NPC who were treated IC CCRT or enrolled....
Gestational choriocarcinoma (GC) is a highly aggressive tumor. In our study, we systematically investigated EpCAM/CD147 expression characteristics in patients with GC and assessed the role of circulating tumor cells (CTCs) predicting chemotherapy response disease progression. tissues were positive for either epithelial cellular adhesion molecule (EpCAM) or CD147, all samples exhibited strong human chorionic gonadotropin (HCG) expression. Among recruited (n = 115), 103 had at least 1 CTC...
Offspring exposed in utero to maternal diabetes exhibit long-lasting insulin resistance, though the initiating mechanisms have received minimal experimental attention. Herein, we show that rat fetuses develop resistance after only 2-day continuous exposure isolated hyperglycemia starting on gestational day 18. Hyperglycemia-induced reductions insulin-induced AKT phosphorylation localized primarily fetal skeletal muscle. The muscle of hyperglycemia-exposed also exhibited impaired vivo glucose...
Backgrounds The patient-generated subjective global assessment (PG-SGA) is one of the screening criteria for malnutrition, skeletal muscle radiodensity (SMD) and mass index (SMI) are associated with survival in colorectal cancer patients. Body composition parameters can be easily assessed; however, few studies have examined association between total wasting scores PG-SGA body two abnormalities. Methods This cohort study included 1,637 stage I-III CRC patients from 2 clinical centers China,...