A5010103624- Diabetes and associated disorders
- Diabetes Management and Research
- Birth, Development, and Health
- Gut microbiota and health
- Pancreatic function and diabetes
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Autopsy Techniques and Outcomes
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diverse Scientific Research Studies
- Cancer-related gene regulation
- RNA modifications and cancer
- interferon and immune responses
- Connective tissue disorders research
- Hormonal and reproductive studies
- Child Nutrition and Water Access
- Gestational Diabetes Research and Management
- Viral gastroenteritis research and epidemiology
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Forensic Anthropology and Bioarchaeology Studies
- Infant Nutrition and Health
First Affiliated Hospital of Harbin Medical University
2013-2024
Harbin Medical University
2013-2024
Shougang (China)
1996
Abstract Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D remains unclear. Here, we integratively profiled gut functional and metabolic alterations children with new-onset independent cohorts investigated the underlying mechanisms. In T1D, microbiota was characterized by decreased butyrate production bile acid metabolism increased lipopolysaccharide biosynthesis at species, gene, metabolite levels. The combination of 18 bacterial species fecal...
Blood microbiome signatures in patients with type 1 diabetes (T1D) remain unclear. We profile blood using 16S rRNA gene sequencing 77 controls and 64 children new-onset T1D, compared it the gut oral microbiomes. The of T1D is characterized by increased diversity perturbed microbial features, a significant increase potentially pathogenic bacteria controls. Thirty-six representative genera were identified random forest analysis, providing strong discriminatory power for an AUC 0.82. PICRUSt...
Abstract Context Aggrecan, encoded by the ACAN gene, is main proteoglycan component in extracellular cartilage matrix. Heterozygous mutations have been reported to cause idiopathic short stature. However, prevalence of pathogenic variants Chinese stature patients and clinical phenotypes remain be evaluated. Objective We sought determine among children characterize phenotypic spectrum their responses growth hormone therapies. Patients Methods Over 1000 unrelated ascertained across China were...
Abstract Context Age of pubertal onset has been decreasing in many countries but there have no data on development Chinese children over the last decade. Objective The primary objective study was to evaluate current status sexual maturation and adolescents. Secondary objectives were examine socioeconomic, lifestyle, auxological associations with onset. Methods In this national, cross-sectional, community-based health survey, a multistage, stratified cluster random sampling method used select...
To investigate the features and treatment status of children with type 1 diabetes mellitus (T1DM) in China.
Aims Findings from previous studies about the association of preterm birth as well weight with risk T1DM were still inconsistent. We aimed to further clarify these associations based on Chinese children and explore role gender therein. Methods A nationwide multicenter population-based large cross-sectional study was conducted in China 2017 2019. Children aged between 3 18 years old complete information included this analysis. Multiple Poisson regression models used for evaluating children....
BACKGROUND In addition to insulin resistance, impaired secretion has recently been identified as a crucial factor in the pathogenesis of type 2 diabetes mellitus (T2DM). Scarce clinical data exist for pediatric T2DM. AIM To investigate association β-cell function and resistance with T2DM first Chinese multicenter study. METHODS This cross-sectional study included 161 newly diagnosed children adolescents between January 2017 October 2019. Children normal glycemic levels (n = 1935) were...
The aim was to determine the burden of diabetes mellitus (DM) in an urban area China aid us planning preventive measures for those at risk DM. A survey conducted among 29 859 subjects aged between 30 and 64 belonging 32 units Shougang Corporation (a heavy industry enterprise) within Beijing area. WHO study protocols diagnostic criteria were used prevalence DM impaired glucose tolerance (IGT). results showed that age-adjusted prevalance (IGT) 3.63 % 4.19 %, respectively, both increasing with...
Abstract Background Growth chart is a valuable clinical tool to monitor the growth and nutritional status of children. A widely used in China based on merged data sets national surveys 2005. We aimed establish an up-to-date, complete curve for urban Chinese children adolescents with full range ages. Methods Using collected large-scale, cross-sectional study (Prevalence Risk factors Obesity Diabetes Youth (PRODY), 2017–2019), we analyzed 201,098 aged 3 18 years from 11 provinces, autonomous...
Diabetes mellitus is now fast emerging as one of the biggest health catastrophes world has ever witnessed. It huge global and societal implications, particularly in developing countries such China India [1]. bring with it potential massive increase type 1 diabetes (2-5% per annum increases incidence world's most populous countries) childhood obesity (with its associated insulin resistance 2 diabetes)[2]. A nine-year prospective study on by WHO DiaMond Project Participating Center Chinese...
Childhood obesity is an energy-metabolic disorder in which excessive accumulation of systemic fat caused by various factors, and it has been confirmed that childhood increases the risk factors diseases such as immune system, cardiovascular system endocrine system.Studies have fibroblast growth factor 21(FGF21)can reduce blood glucose, glucagon, triglyceride improve islet cell function, makes FGF21 a promising drug treatment diabetes, metabolic syndrome.However, underlying mechanisms not...