A5102024044- Probiotics and Fermented Foods
- Gut microbiota and health
- Genetic Mapping and Diversity in Plants and Animals
- Mycotoxins in Agriculture and Food
- Antibiotic Resistance in Bacteria
- Plant-Microbe Interactions and Immunity
- Wheat and Barley Genetics and Pathology
- Marine Bivalve and Aquaculture Studies
- Cancer Research and Treatments
- Plant Pathogenic Bacteria Studies
- Rice Cultivation and Yield Improvement
- Polyamine Metabolism and Applications
- Antimicrobial Peptides and Activities
- Gene expression and cancer classification
- Antibiotic Use and Resistance
- Fermentation and Sensory Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Genetic Associations and Epidemiology
- Food composition and properties
- GABA and Rice Research
- Protein Hydrolysis and Bioactive Peptides
- Marine Biology and Environmental Chemistry
- Biochemical effects in animals
- Pharmacogenetics and Drug Metabolism
- Plant Gene Expression Analysis
Chinese Academy of Agricultural Sciences
2020-2025
Ministry of Agriculture and Rural Affairs
2010-2025
Feed Research Institute
2022-2025
Institute of Crop Sciences
2020-2025
China Agricultural University
2010-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Minhang District Central Hospital
2021-2024
Fudan University
2021-2024
Dalian Ocean University
2018-2024
Nanjing Drum Tower Hospital
2017-2024
Abstract Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D remains unclear. Here, we integratively profiled gut functional and metabolic alterations children with new-onset independent cohorts investigated the underlying mechanisms. In T1D, microbiota was characterized by decreased butyrate production bile acid metabolism increased lipopolysaccharide biosynthesis at species, gene, metabolite levels. The combination of 18 bacterial species fecal...
With the rapid advancement of genetic and protein engineering, proteins peptides have emerged as promising drug molecules for therapeutic applications. Consequently, there has been a growing interest in field chemical modification technology to address challenges associated with their clinical use, including clearance from circulation, immunogenicity, physical instabilities (such aggregation, adsorption, deamination, clipping, oxidation, etc.), enzymatic degradation. Polyethylene glycol...
Purpose:The incidence of hepatocellular carcinoma (HCC) is extremely high, and China accounts for approximately 50% global liver cancer cases.Previous studies reported that CDC20 involved in the occurrence progression a variety malignant tumors.So, whether will affect development HCC, we have conducted in-depth research on this.Methods: We selected Hep3B HepG2 cell culture, performed siRNA transfection, lentiviral infection, western blot, MTS determination, cycle apoptosis test,...
The co-occurrence of aflatoxin B1 (AFB1) and zearalenone (ZEN) in grain-based food animal feed poses significant health risks to humans animals due their potent mutagenic, cytotoxic, carcinogenic properties. Conventional physical chemical methods are insufficient for effectively detoxifying multiple mycotoxins present feed. In this study, we evaluated the capability Bacillus subtilis ZJ-2019-1 (B. ZJ-2019-1) simultaneously degrade AFB1 ZEN while optimizing reaction enhance degradation...
Lactobacilli have played an important role in the gut health of pets. The aim this research was to study effects isolated (named L11) on immune, nutrient metabolism, and cats. Twelve healthy adult cats were randomly assigned into two groups, control group (CONTROL, n = 6, without any probiotics product) treatment (probiotics, L11 109 CFU/kg feed), while using same dry diet. On day 28, blood fecal samples collected, biochemical indices, microbiota, short-chain fatty acids (SCFAs),...
Detecting epistatic interactions associated with complex and common diseases can help to improve prevention, diagnosis treatment of these diseases. With the development genome-wide association studies (GWAS), designing powerful robust computational method for identifying becomes a great challenge bioinformatics society, because study often deals large size genotyped data huge amount combinations all possible genetic factors. Most existing detection methods are based on classification...
Salidroside (SAL) is the major ingredient of Rhodiola rosea, and has been traditionally used in Chinese medicine for decades. Numerous studies have demonstrated protective effects SAL myocardial ischemia. However, it yet to be deciphered whether cardioprotective after infarction (MI) vivo. In present study, we established a mouse MI model via coronary artery ligation. The aim was investigate treatment could reduce mortality, improve cardiac function attenuate remodeling mice. Post-surgery,...
Lactic acid bacteria play a crucial role in maintaining the health of host’s gut microbiota. In this study, anti-inflammatory properties Limosilactobacillus reuteri LR20-6 and Lacticplantibacillus plantarum L272 were evaluated using mouse model diarrhea induced by Escherichia coli. We also investigated their effects on microbiota regulation. The results indicated that both could reduce inflammation inhibiting expression inflammatory factors IL-6 TNF-α blocking MyD88 NF-kB/p65 signaling...
To investigate the anti-bacterial and anti-inflammatory properties of sophoridine elucidate its mechanism action, we carried out both in vitro vivo experiments. Multiple bacterial strains were utilized to determine effective concentration antibacterial bactericidal assays. Subsequently, LPS-stimulated RAW264.7 cells E. coli-challenged BALB/c mice models employed evaluate production inflammatory cytokines. Our results showed that concentrations exceeding 5.12 mg/mL significantly inhibited...
Yeast hydrolysate (YH) is rich in amino acids and other nutrients, as a nutritional supplement it has been widely used daily supplements for livestock. However, the role of YH domestic pets, especially cats, not yet determined. The objective this research was to study effects different concentrations on healthy cats. All cats were randomly divided into four treatments: control group (T0, n = 6, without YH), treatment 1 (T1, low concentration group, 0.8% YH, 6), 2 (T2, middle 1.5% 3 (T3, high...