A5083197388- Essential Oils and Antimicrobial Activity
- Antifungal resistance and susceptibility
- Lung Cancer Treatments and Mutations
- Antimicrobial Peptides and Activities
- Natural Compounds in Disease Treatment
- Family Support in Illness
- Hip and Femur Fractures
- Quinazolinone synthesis and applications
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related cognitive impairment studies
- Colorectal Cancer Treatments and Studies
- Lipoproteins and Cardiovascular Health
- Fungal Plant Pathogen Control
- Advancements in Transdermal Drug Delivery
- Diabetes Treatment and Management
- Bone Metabolism and Diseases
- Pharmacological Effects and Toxicity Studies
- Bone health and osteoporosis research
- Chronic Myeloid Leukemia Treatments
- Shoulder Injury and Treatment
- Cancer survivorship and care
- Drug Transport and Resistance Mechanisms
- Drug-Induced Adverse Reactions
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacovigilance and Adverse Drug Reactions
Fudan University
2019-2024
Minhang District Central Hospital
2017-2024
Shanghai Genon Biological Products (China)
2023
Eye & ENT Hospital of Fudan University
2023
Shanghai Ninth People's Hospital
2020-2022
Zhejiang Provincial People's Hospital
2021
Weatherford College
2020
Wenzhou Medical University
2018
First Affiliated Hospital of Wenzhou Medical University
2018
Florida College
1997
Atorvastatin and its lactone form metabolite are reported to be associated with statin-induced myopathy (SIM) such as myalgia life-threatening rhabdomyolysis. Though the rhabdomyolysis is not common during statin therapy, incidence will significantly increase due pharmacokinetic drug-drug interactions (DDIs) inhibitor drugs which inhibit atorvastatin's lactone's metabolism hepatic uptake. Thus, quantitative analysis of DDIs atorvastatin cytochrome P450 3A4 (CYP3A4) organic anion-transporting...
Aim: Apatinib is an orally administered vascular epidermal growth factor receptor (VEGFR)-tyrosine kinase inhibitors approved for the treatment of advanced gastric adenocarcinoma or esophageal junction adenocarcinoma. predominantly metabolized by CYP3A4/5, followed CYP2D6. The present study aimed to evaluate potential drug-drug interaction (DDI) and drug-disease (DDZI) risks apatinib in Chinese volunteers. Methods: Modeling simulation were conducted using Simcyp Simulator. input parameters...
In vitro interaction of osthol (Ost) and fluconazole (FLC) was investigated against 11 fluconazole-resistant clinical isolates Candida albicans. Synergistic activities were determined using the checkerboard microdilution assay. The results agar diffusion test confirmed synergistic interaction. We used an enteric material Eudragit S100 for preparation Ost nanoparticle (Ost-NP) to improve oral bioavailability, biological activity Ost. physicochemical characteristics Ost-S100-NP revealed with...
Osteoporosis is a clinically common metabolic disease, especially in postmenopausal women. Tai Chi might be beneficial osteoporosis patients. This study will performed to examine the effects of on bone mineral density osteoporosis.We search electronical databases and hand-searching journals or reference lists. The screening data extraction carried out by 2 investigators independently. primary outcome (lumbar spine, Ward's triangle, trochanter, proximal femur, femoral neck, total hip)....
Several pharmacological agents, such as chloroquine/hydroxychloroquine, have been promoted for COVID-19 treatment or pre-exposure prophylaxis. However, no comprehensive evaluation of the safety these possible agents is available, and urgently needed. The purpose this study was to investigate risks cardiac adverse events associated with pharmacotherapies COVID-19, including certain antimalarial, antiviral, antibiotic drugs. We conduced retrospective pharmacovigilance analyses US Food Drug...
Objective. To determine whether arthrographic distention combined with manipulation for frozen shoulder provides additional benefits. Methods. A total of 180 participants from five clinical centers pain and stiffness in predominantly 1 >3 months entered the study, 165 completed study. The control group was treated alone, treatment underwent after resting 5 minutes following distention. Patients were followed up at one two weeks three six months. For evaluation, shoulder-specific...
Aim: It has been found that the co-administration of nifedipine with apatinib could cause exposure changes in vivo. But, whether this pharmacokinetic drug-drug interaction (DDI) between and enhance antihypertensive effect nifedipine, causing sever blood pressure was unknown. Therefore, aim present study to conduct pharmacokinetic/pharmacodynamic (PK/PD) modelling evaluate on nifedipine. Thus, results guide these two drugs clinic. Methods: A physiologically-based (PBPK) model first developed...
Ensartinib (X-396) is a second-generation anaplastic lymphoma kinase (ALK) tyrosine inhibitor (TKI) indicated for the treatment of ALK-positive patients with locally advanced or metastatic non-small cell lung cancer. Although in vitro experiments and molecular docking suggested its potential as cytochrome P450 inhibitor, no further investigation clinical trials have been conducted to assess drug-drug interaction (DDI) risk. In this study, we series elucidate inhibition mechanism ensartinib....
Abstract Aims The present study aimed to quantitatively investigate the potential drug–drug interaction (DDI) mechanism between meropenem (MEPM) and valproic acid (VPA). Methods In study, we firstly developed a physiologically based pharmacokinetic (PBPK) model of MEPM VPA. verified PBPK was then used DDI effect genetic polymorphisms acylpeptide hydrolase (APEH) on also evaluated. Results our simulation, plasma concentration hydrolysate VPAG decreased 63% when combined with MEPM. Total VPA...