A5028460928- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Vitamin D Research Studies
- Alcohol Consumption and Health Effects
- Lipid metabolism and disorders
- Sleep and related disorders
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Stress Responses and Cortisol
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Nerve injury and regeneration
- Autism Spectrum Disorder Research
- COVID-19 and Mental Health
- Healthcare professionals’ stress and burnout
- Diet and metabolism studies
- Bone health and treatments
- Neurotransmitter Receptor Influence on Behavior
- Neurological Disorders and Treatments
- Vitamin C and Antioxidants Research
- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
Wenzhou Medical University
2015-2025
First Affiliated Hospital of Wenzhou Medical University
2015-2025
Sun Yat-sen University
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Nantong University
2023
North China University of Science and Technology
2020-2022
The First People's Hospital of Xiaoshan District, Hangzhou
2021
Wuhan University of Science and Technology
2020
Ruian People's Hospital
2016
Mounting evidence suggests that mitochondrial dysfunction and impaired mitophagy lead to Parkinson's disease (PD). Quercetin, one of the most abundant polyphenolic flavonoids, displays many health-promoting biological effects in diseases. We explored neuroprotective effect quercetin vivo 6-hydroxydopamine (6-OHDA)-lesioned rat model PD vitro 6-OHDA-treated PC12 cells. In vitro, we found (20 μM) treatment improved quality control, reduced oxidative stress, increased levels markers PINK1...
Abstract Cannabidiol (CBD), an abundant nonpsychoactive constituent of marijuana, has been reported previously to protect against hepatic steatosis. In this study, we studied further the functions and mechanisms CBD on liver inflammation induced by HFC diet. Mice feeding diet for 8 weeks were applied test protective effect livers. RAW264.7 cells incubated with LPS + ATP ± study inflammasome activation. We found that alleviated significantly inhibited nuclear factor‐κappa B (NF‐κB) p65...
Background: The epithelial tight junction is an important intestinal barrier whose disruption can lead to the release of harmful substances into circulation and cause damage systemic injury. maintenance junctions closely related energy homeostasis mitochondrial function. Nicotinamide riboside (NR) a NAD booster that enhance biogenesis in liver. However, whether NR prevent ethanol-induced dysfunction underlying mechanisms remain unclear. Methods: We applied mouse NIAAA model (chronic plus...
Alcohol abuse and high-fat diet–induced liver diseases have been the most prevalent chronic leading reasons for transplantation around world. Cannabidiol (CBD) is a botanical component extracted from marijuana plants without psychoactive impact. In our previous reports, we found that CBD can prevent fatty induced by Lieber–DeCarli ethanol diet or non-alcoholic disease (NAFLD) high-cholesterol diet. The current work further study on whether alleviate injuries plus (EHFD), which model...
Purpose: Cognitive behavioral therapy (CBT) for depression had been found to be effective in reducing depressive and anxiety symptoms breast cancer survivors. It is not known whether CBT would also improve insomnia quality of life (QOL). The aim this study was investigate QOL a randomized controlled multicenter trial. Patients methods: In study, survivors (n=392) were randomly allocated the following three groups: (n=98), self-care management (SCM, n=98), usual care (UC, n=196) ratio 1:1:2....
Targeting Nicotinamide adenine dinucleotide (NAD) metabolism has emerged as a promising anti-cancer strategy; we aimed to explore the health benefits of boosting NAD levels with nicotinamide riboside (NR) on hepatocellular carcinoma (HCC). We established three in vivo tumor models, including subcutaneous transplantation model both Balb/c nude mice (xenograft), C57BL/6J (allograft), and hematogenous metastatic neoplasm mice. NR (400 mg/kg bw) was supplied daily gavage. In-situ growth or...
Poststroke depression (PSD) is a frequent complication of stroke that has been associated with poorer outcome patients. This study sought to examine the possible association between serum uric acid levels and development PSD. We recruited 196 patients acute ischemic 100 healthy volunteers. Serum were tested by uricase-PAP method within 24 hr after admission. Neuropsychological evaluations conducted at 3-month poststroke. The 17-item Hamilton Depression Scale was used assess depressive...
Low levels of serum vitamin D are common in patients with mood disorders and stroke. It has been shown that low indicate a risk depression post-stroke subjects. Our aim was to determine the relationship between anxiety (PSA). A consecutive series 226 first acute ischemic stroke were recruited followed up for 1 month. Serum measured within 24 hours admission. Patients significant clinical symptoms Hamilton scale score >7 diagnosed as having PSA. In addition, 100 healthy subjects controls...
Whether leukoaraiosis burden retards short-term recovery after minor stroke is unclear. We investigated the association between and early of neurological function a first ischemic in 217 acute patients (National Institutes Health Stroke Scale (NIHSS) score ≤5). Leukoaraiosis severity was graded according to Fazekas scale categorized into none mild (0–2; n = 143) or severe (3–6; 74) groups. NIHSS Minimum Mental State Examination (MMSE) were assessed at baseline 30 days. Univariate analysis...
The serum triglyceride (TG) and total cholesterol (TC) levels have been reported altered in the traditional drug-dependence (such as marijuana heroin). However, studies assessing relationships among TC, TG, methamphetamine (MA)-dependence not described well. In this study, our aim is to explore TG TC large sample of MA-dependent patients. A retrospective study was conducted 938 patients who were recruited between February 2, 2008 March 11, 2013, with social characteristics history (duration...
MyoD is a skeletal muscle-specifically expressed transcription factor and plays critical role in regulating myogenesis during muscle development regeneration. However, whether myofibers-expressed exerts its metabolic function whole body energy homeostasis vivo remains largely unknown. Here, we report that genetic deletion of Myod male mice enhances the oxidative metabolism and, intriguingly, renders resistant to high fat diet-induced obesity. By performing lipidomic analysis...
A panel of experts proposed a new definition metabolic dysfunction-associated fatty liver disease (MAFLD) in 2020. To date, the associations between adipokines, such as adiponectin, adipsin, and visfatin MAFLD remain unclear. Therefore, we aimed to evaluate each these three adipokines using different diagnostic criteria. In total, 221 participants were included our study based on medical examination. Detailed questionnaire information, physical examination, abdominal ultrasound,...
Post-stroke depression (PSD) is a common psychiatric complication of stroke that associated with poor outcome in patients. Our aim was to assess the association between serum magnesium levels and presence PSD Chinese Two hundred nine patients were included study. Depressive symptoms measured by 17-Hamilton Rating Scale for Depression at 3 months after stroke. Based on depressive symptoms, diagnoses made line DSM-IV criteria PSD. Serum evaluated using dimethyl aniline blue colorimetric method...
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) has long been recognized as an adipokine. However, the exact role of eNAMPT in alcoholic liver disease (ALD) and its relevance to brown adipose tissue (BAT) remain largely unknown. This study aimed evaluate impact on function underlying mechanisms involved BAT-Liver communication.