A5102006247- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Genomics and Chromatin Dynamics
- Adipokines, Inflammation, and Metabolic Diseases
- Protein Degradation and Inhibitors
- Sirtuins and Resveratrol in Medicine
- Muscle Physiology and Disorders
- Cancer Genomics and Diagnostics
- Exercise and Physiological Responses
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone and Joint Diseases
- Bone health and treatments
- Sinusitis and nasal conditions
- Protein Kinase Regulation and GTPase Signaling
- Mycobacterium research and diagnosis
- Advanced Glycation End Products research
- PI3K/AKT/mTOR signaling in cancer
- Diet, Metabolism, and Disease
- Actinomycetales infections and treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
WinnMed
2025
Eye & ENT Hospital of Fudan University
2024
Clinical Trial Investigators
2024
Emerald Coast Science Center
2024
Peking Union Medical College Hospital
2023
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2023
Guizhou University
2022
ABSTRACT Genes involved in the regulation of chromatin structure are frequently disrupted cancer, contributing to an aberrant transcriptome and phenotypic plasticity. Yet, therapeutics targeting mutant forms chromatin-modifying enzymes have yielded only modest clinical utility, underscoring difficulty epigenomic underpinnings gene regulatory networks. Here, we sought identify novel epigenetic vulnerabilities diffuse large B-cell lymphoma (DLBCL). Through screens biochemical analysis,...
MyoD is a skeletal muscle-specifically expressed transcription factor and plays critical role in regulating myogenesis during muscle development regeneration. However, whether myofibers-expressed exerts its metabolic function whole body energy homeostasis vivo remains largely unknown. Here, we report that genetic deletion of Myod male mice enhances the oxidative metabolism and, intriguingly, renders resistant to high fat diet-induced obesity. By performing lipidomic analysis...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory upper airway disease, divided into eosinophilic CRSwNP (eCRSwNP) and noneosinophilic (neCRSwNP) according to levels. Neutrophils are major effector cells in CRSwNP. but their role different environments remain largely unclear. We performed integrated transcriptome analysis of polyp-infiltrating neutrophils from patients, using healthy donor blood as a control. Flow cytometry vitro studies showed that activated both type....
Abstract Skeletal muscle is the largest metabolic and endocrine organ. It secretes various peptides that contribute to regulating body energy homeostasis by communicating with other organs. However, it unknown whether muscle-secreted lipids exert a similar function. Myod specifically expressed in skeletal muscle. Here, we report genetic deletion of mice enhanced oxidative metabolism and, intriguingly, rendered resistant HFD-induced obesity. By performing lipidomic analysis muscle-conditioned...