A5101813732- Insect symbiosis and bacterial influences
- Insect-Plant Interactions and Control
- Insect behavior and control techniques
- Insect and Pesticide Research
- Invertebrate Immune Response Mechanisms
- Animal Ecology and Behavior Studies
- Insect and Arachnid Ecology and Behavior
- Concrete and Cement Materials Research
- Sinusitis and nasal conditions
- Parasite Biology and Host Interactions
- Forest Insect Ecology and Management
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Neurobiology and Insect Physiology Research
- Genetic factors in colorectal cancer
- Plant and animal studies
- Pharmacological Effects and Toxicity Studies
- Magnesium Oxide Properties and Applications
- Building materials and conservation
- Mitochondrial Function and Pathology
- Grouting, Rheology, and Soil Mechanics
- Cancer-related molecular mechanisms research
- Evolution and Genetic Dynamics
- Epilepsy research and treatment
- Colorectal Cancer Treatments and Studies
Zhejiang University
2012-2025
China National Rice Research Institute
2025
State Key Laboratory of Rice Biology
2025
St. Jude Children's Research Hospital
2024
Eye & ENT Hospital of Fudan University
2024
Ministère de l'Agriculture et de la Souveraineté alimentaire
2024
Southeast University
2024
Fudan University
2024
Xi'an University of Architecture and Technology
2021-2023
Hebei Normal University
2022
Abstract Background Plants differ more than threefold in seed oil contents (SOCs). Soybean ( Glycine max ), cotton Gossypium hirsutum rapeseed Brassica napus and sesame Sesamum indicum ) are four important crops with markedly different SOCs fatty acid compositions. Results Compared to grain like maize rice, expanded acyl-lipid metabolism genes relatively higher expression levels of involved synthesis (SOS) the contributed accumulation seeds. Here, we conducted comparative transcriptomics on...
Abstract Parasitoids are ubiquitous in natural ecosystems. Parasitic strategies highly diverse among parasitoid species, yet their underlying genetic bases poorly understood. Here, we focus on the divergent adaptation of a specialist and generalist drosophilid parasitoids. We find that novel protein (Lar) enables active immune suppression by lysing host lymph glands, eventually leading to successful parasitism generalist. Meanwhile, another (Warm) contributes passive strategy attaching laid...
Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis than patients stable (MSS) CRC. However, some MSI-H CRC do not gain overall survival benefits from immune checkpoint-blockade treatment. In other words, heterogeneity within the subgroup of tumors remains poorly understood. Thus, an in-depth molecular characterization is urgently required. Here, we use nonnegative matrix factorization (NMF)-based consensus clustering to define...
It is widely accepted that the oxygen level in tumor tissue significantly lower than adjacent normal tissue, thus termed hypoxia. Intratumoral hypoxia represents a major driving force cancer progression, recurrence, metastasis, and decreased survival. Though multiple gene signatures reflect complex cellular response to have been established several types such as head neck, breast, lung cancers, hypoxic panorama colorectal (CRC) remains poorly understood.A signature constituted by total of...
Abstract Making the appropriate responses to predation risk is essential for survival of an organism; however, underlying mechanisms are still largely unknown. Here, we find that Drosophila has evolved adaptive strategy manage threat from its parasitoid wasp by manipulating oviposition behavior. Through perception differences in host search performance wasps, able recognize younger wasps as a higher level and consequently depress oviposition. We further show this antiparasitoid behavior...
The success of an organism depends on the molecular and ecological adaptations that promote its beneficial fitness. Parasitoids are valuable biocontrol agents for successfully managing agricultural pests, they have evolved diversified strategies to adapt both physiological condition hosts competition other parasitoids. Here, we deconstructed parasitic in a highly successful parasitoid, Trichopria drosophilae , which parasitizes broad range Drosophila hosts, including globally invasive...
Leptopilina wasps are crucial for biological pest control, particularly against the globally emerging Drosophila suzukii. Despite their ecological significance, genomic basis of host selection and parasitism in this genus remains underexplored. In study, we assembled a high-quality, chromosome-level genome myrica, species collected Taizhou, Zhejiang Province, China. We employed combination PacBio long-read sequencing, Illumina short-read Hi-C technology to produce assembly approximately...
Animals often exhibit increased aggression in response to starvation, while parasites manipulate host behavior. In contrast, underlying molecular mechanisms for these behavioral changes are mostly unknown. The diamondback moth, Plutella xylostella , is an agricultural pest that feeds on cruciferous plants as larvae, Cotesia vestalis a parasitoid wasp parasitizes moth larvae. this study, we determined unparasitized larvae and cannibalism when starved, starved parasitized by C. were more...
Abstract Intraspecific competition is a major force in mediating population dynamics, fuelling adaptation, and potentially leading to evolutionary diversification. Among the arms races between parasites, one of most fundamental intriguing behavioural adaptations counter-adaptations are superparasitism avoidance. However, underlying mechanisms ecological contexts these phenomena remain underexplored. Here, we apply Drosophila parasite Leptopilina boulardi as study system find that this...
Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis , an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction lipid levels. This process requires excess secretion P . tachykinin (PxTK) peptides from enteroendocrine cells (EEs) in midgut parasitized larvae. We found parasitization upregulates PxTK signaling to suppress lipogenesis enterocytes (ECs)...
Abstract Patients with right-sided colon cancer (RCC) generally have a poorer prognosis than those left-sided (LCC). We previously found that homeobox C6 ( HOXC6 ) was the most significantly upregulated gene in RCC compared to LCC. However, it remains unclear whether plays role tumor proliferation and metastasis. Our study aimed explore potential oncogenic detailed molecular mechanism of RCC. In this study, validated be overexpressed associated poor prognosis. Furthermore, overexpression...
Abstract Studying the microbial symbionts of eukaryotic hosts has revealed a range interactions that benefit host biology. Most eukaryotes are also infected by parasites adversely affect biology for their own benefit. However, it is largely unclear whether ability to develop in depends on host-associated symbionts, e.g., gut microbiota. Here, we studied parasitic wasp Leptopilina boulardi (Lb) and its Drosophila melanogaster. Results showed Lb successfully develops conventional (CN) with...
Abstract Trichopria drosophilae (Hymenoptera: Diapriidae) is an important pupal endoparasitoid of Drosophila melanogaster Meigen (Diptera: Drosophilidae) and some other fruit fly species, such as D. suzukii , a very invasive economic pest. Studies T. suggest that this could be good biological control agent for pests. In research, we compared the parasitic characteristics reared in (TD m ) with those hydei h ). TD had larger size than . The number maximum mature eggs female was 133.6 ± 6.9,...
Abstract Background The role and mechanism of the nicotinamide adenine dinucleotide (NAD + ) salvage pathway in cancer cell proliferation is poorly understood. Nicotinamide phosphoribosyltransferase (NAMPT), which converts into NAD , rate-limiting enzyme pathway. Here, we assessed NAMPT colorectal cancer. Methods Real-time PCR, immunohistochemistry, western blotting, analyses datasets from Oncomine Gene Expression Omnibus were conducted to assess expression at mRNA protein levels Kaplan...
Vitellogenin receptor (VgR) is essential to vitellogenin uptaking and dominates ovary maturation in insects. However, the function of VgR parasitoid wasps largely unknown. Here, we applied Drosophila Leptopilina boulardi as a study model investigate parasitoids. Despite conserved sequence characteristics with other insect VgRs, found L. (LbVgR) gene was highly expressed head but lower ovary. In addition, that LbVgR had no effects on development, participated host-searching behavior female...
Parasitoids commonly manipulate their host’s metabolism and immunity to facilitate offspring survival, but the mechanisms remain poorly understood. Here, we deconstructed manipulation strategy of a newly discovered parasitoid wasp, L. myrica, which parasitizes D. melanogaster. Using RNA-seq, analyzed transcriptomes myrica-parasitized non-parasitized Drosophila host larvae. A total 22.29 Gb 23.85 clean reads were obtained from two samples, respectively, differential expression analysis...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory upper airway disease, divided into eosinophilic CRSwNP (eCRSwNP) and noneosinophilic (neCRSwNP) according to levels. Neutrophils are major effector cells in CRSwNP. but their role different environments remain largely unclear. We performed integrated transcriptome analysis of polyp-infiltrating neutrophils from patients, using healthy donor blood as a control. Flow cytometry vitro studies showed that activated both type....