A5007700786- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- biodegradable polymer synthesis and properties
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Advanced SAR Imaging Techniques
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Endometriosis Research and Treatment
- Brain Tumor Detection and Classification
- Endoplasmic Reticulum Stress and Disease
- Modular Robots and Swarm Intelligence
- Genetic factors in colorectal cancer
- AI in cancer detection
- Environmental Changes in China
- Advanced Differential Equations and Dynamical Systems
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Synthesis and properties of polymers
- Microwave Imaging and Scattering Analysis
- Macrophage Migration Inhibitory Factor
- Quantum chaos and dynamical systems
Harbin Medical University
2023-2025
Fourth Affiliated Hospital of Harbin Medical University
2023-2025
Peking University
2020-2025
Second Affiliated Hospital of Zhejiang University
2025
Jiaxing University
2024
Zhejiang Chinese Medical University
2024
Weatherford College
2024
Shantou University
2023
Hanshan Normal University
2023
Shantou University Medical College
2023
Polyoxazoline polymers with methyl (PMOZ), ethyl (PEOZ), and propyl (PPOZ) side chains were prepared by the living cationic polymerization method purified ion-exchange chromatography. The following properties of polyoxazoline (POZ) measured: apparent hydrodynamic radius aqueous size-exclusion chromatography, relative lipophilicity reverse-phase viscosity cone–plate viscometry. PEOZ different molecular weights first functionalized then conjugated to model biomolecules such as bovine serum...
Automatic generation of facial images has been well studied after the Generative Adversarial Network (GAN) came out. There exists some attempts applying GAN model to problem generating anime characters, but none existing work gives a promising result. In this work, we explore training models specialized on an image dataset. We address issue from both data and aspect, by collecting more clean, well-suited dataset leverage proper, empirical application DRAGAN. With quantitative analysis case...
Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), as a common chronic liver condition globally, is experiencing an increasing incidence rate which poses significant health risks. Despite this, the detailed mechanisms underlying disease's onset and progression remain poorly understood. In this study, we aim to identify effective diagnostic biomarkers for MASLD using microarray data combined with machine learning techniques, will aid in further understanding...
Precise isolation and analysis of circulating tumor cells (CTCs) from blood samples offer considerable potential for cancer research personalized treatment. Currently, available CTC approaches remain challenging in the quest simple strategies to achieve cell with both high separation efficiency purity, which limits use captured CTCs downstream analyses. Here, we present a filter deterministic lateral displacement concept one-step label-free throughput. Unlike conventional (DLD) devices,...
ABSTRACT Currently available dopaminergic drugs such as levodopa and dopamine (DA) receptor agonists impart considerable improvement in Parkinson's disease (PD) motor symptoms but often lead to significant complications including “wearing‐ off ” dyskinesia. Such are believed stem from the pulsatile nature of stimulation with these agents. Continuous drug delivery using polyoxazoline (POZ) polymer conjugation may improve symptoms, while avoiding development side effects. The purposes current...
Neoadjuvant chemotherapy (NACT) is the standard-of-care treatment for patients with locally advanced breast cancer (LABC), providing crucial benefits in tumor downstaging. Clinical parameters, such as molecular subtypes, influence therapeutic impact of NACT. Moreover, severe adverse events delay process and reduce effectiveness therapy. Although metabolic changes during are determinant factors responses toxicities, related clinical research remains limited. One hundred paired blood samples...
Cartilage regeneration in juvenile mice was better than adult mice. This study evaluated the roles of cytokines and reactive oxygen species (ROS) after cartilage injury both attempted to correlate these with progenitor cells age-related differences regeneration. Full-thickness defects were created femoral trochlea knee joints 4-week-old (juvenile) 8-week-old (adult) Adult showed higher ROS peaks juveniles at day 7 post-injury. Protein expression levels tumor necrosis factor-α (TNF-α)...
Abstract Common polygenic diseases result from compounded risk contributed by multiple genetic variants, meaning that simultaneous correction or introduction of single nucleotide variants is required for disease modeling and gene therapy. Here, we show precise, efficient, multiplex base editing up to three target sites across 11 genes/loci in cynomolgus monkey embryos using CRISPR-based cytidine- adenine-base editors. Unbiased whole genome sequencing demonstrates high specificity embryos....
Oxidative nucleic acid modifications have attracted increasing attention in recent years since they been found to be related a number of diseases including cancer. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) and 8-hydroxyguanosine (8-OHG) are the typical markers oxidative modification DNA RNA, respectively, emerging biomarkers for early detection diseases. Urine is favored biofluid biomarker discovery due its noninvasiveness patients. Accurate quantification these still has challenges because their...
Abstract Patients with right-sided colon cancer (RCC) generally have a poorer prognosis than those left-sided (LCC). We previously found that homeobox C6 ( HOXC6 ) was the most significantly upregulated gene in RCC compared to LCC. However, it remains unclear whether plays role tumor proliferation and metastasis. Our study aimed explore potential oncogenic detailed molecular mechanism of RCC. In this study, validated be overexpressed associated poor prognosis. Furthermore, overexpression...
ABSTRACT Aging-related osteoporosis (OP) is considered a serious public health concern. Approximately 30% of postmenopausal women suffer from OP; more than 40% them risk fragility fractures. Multiple drugs have been prescribed to treat OP, but they are not ideal because low cure rates and adverse side effects. miRNA-based gene therapy rapidly developing strategy in disease treatment that presents certain advantages, such as large-scale production capability, genetic safety, rapid miRNA used...
RNA methylation plays a vital role in the pathogenesis of variety diseases including cancer, and aberrant levels modified nucleosides were revealed to be related cancer. Urine is favored source for biomarker discovery due non-invasion patients. Herein, we developed sensitive hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC-MS/MS) method combined with stable isotope dilution accurate quantification methylated human urine. With this method, successfully quantified...
Ischemic cerebrovascular disease is a significant and common public health issue worldwide. The emerging roles of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) in ischemic neuronal injury continue to be investigated. current study aimed investigate the role EV-derived miR-132 from MSCs injury. EVs were initially isolated bone (BMSCs) subsequently evaluated. A middle cerebral artery occlusion (MCAO) mouse model was constructed with neurological function evaluated through...