A5100402273- Blood groups and transfusion
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Multiple Myeloma Research and Treatments
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cardiac Ischemia and Reperfusion
- Hematological disorders and diagnostics
- Advanced Breast Cancer Therapies
- Inflammasome and immune disorders
- Pluripotent Stem Cells Research
- Zoonotic diseases and public health
- Molecular Biology Techniques and Applications
- Chronic Myeloid Leukemia Treatments
- Viral Infections and Vectors
- Bone and Joint Diseases
- Erythrocyte Function and Pathophysiology
- Folate and B Vitamins Research
- Protease and Inhibitor Mechanisms
- Trace Elements in Health
- Autoimmune Bullous Skin Diseases
- Iron Metabolism and Disorders
Weifang People's Hospital
2024
Chinese Center For Disease Control and Prevention
2024
Xuzhou Medical College
2024
Hospital of the University of Pennsylvania
2020-2023
State Key Laboratory of Natural Medicine
2021
China Pharmaceutical University
2021
Lanzhou University
2019
Lanzhou University Second Hospital
2019
Southern Medical University
2010-2018
Nanjing General Hospital of Nanjing Military Command
2018
Benzene is an occupational toxicant and environmental pollutant that potentially causes hematotoxicity leukemia in exposed populations. Epidemiological studies suggest association between increased incidence of childhood benzene exposure during the early stages pregnancy. However, experimental evidence supporting lacking at present time. It believed its metabolites target hematopoietic stem cells (HSCs) to cause toxicity cancer system. In current study, we compared effects hydroquinone (HQ),...
Ionized calcium binding adaptor molecule 1 (IBA1), a marker of microglia/macrophages, has not been investigated in human hematopathologic contexts. We evaluated its expression mature and immature neoplasms monocytic/histiocytic dendritic cell (DC) origin.Immunohistochemistry for IBA1, CD14, CD68, CD163 was performed on total 114 cases, including spectrum DC (20 tissue based 59 bone marrow based) several nonhistiocytic/monocytic/DC as control groups (15 20 based).IBA1 observed all types...
Phenotype D-- is associated with severe hemolytic transfusion reactions and disease of the fetus newborn. It typically caused by defective RHCE genes. In this study, we identified a phenotype proband verified Rh phenotypes other 6 family members. However, inconsistent results between phenotypic analysis Sanger sequencing revealed intact exons no mutations in proband, but protein was not expressed. Subsequent whole-genome Oxford Nanopore Technologies an inversion ambiguous breakpoints intron...
Abstract Hematopoietic stem cells (HSCs) have emerged as promising therapeutic cell sources for high-risk hematological malignancies and immune disorders. However, their clinical use is limited by the inability to expand these ex vivo . Therefore, there an urgent need identify specific targets effective probes that can HSCs. Here we report a novel class of INK4C (p18 or p18) small molecule inhibitors (p18SMIs), which were initially found in silico 3D screening. We identified lead p18...
Abstract Some patients have poor response to adult-onset Still disease (AOSD) traditional treatment, which easily recurs during the reduction of prednisone. We observed efficacy and safety tocilizumab combined with methotrexate (MTX) in treatment refractory AOSD, explore possibility reducing dosage after control. A total 28 AOSD cases who had an inadequate corticosteroids at least 1 immunosuppressive agent, even large-dose prednisone could not relieve their conditions recurrence, were...
The aim of this study was to investigate the protective role erythropoietin (EPO) against myocardial fibrosis (MF).Pressure-overloaded rats were established by abdominal aortic constriction, randomly divided in a double-blind manner into 3 groups (n = 12 for each group): sham-operated (sham), operated receiving physiological saline (vehicle) and 4,000 U/kg rhEPO (EPO group). vehicle drugs administered intraperitoneal injection. In addition, cultured adult rat cardiac fibroblasts (CFs)...
Septic cardiomyopathy (SCM) is a significant global public health concern characterized by substantial morbidity and mortality, which has not been improved for decades due to lack of early diagnosis effective therapies. This study aimed identify hub biomarkers in SCM explore their potential mechanisms.
The rapid development of automatic blood cell analyzers has greatly optimized complete count results. However, erroneous results relevant to still exist. Pseudothrombocytopenia can be observed in both cases anticoagulant-induced platelet aggregation, and the presence large giant platelets.
Background:AT-III gene mutations are associated with venous thromboembolism (VTE) in pregnant women or puerperants. In this study we established a denaturing high-performance liquid chromatography (DHPLC) assay to screen mutation/polymorphism of the AT-III gene.
Abstract Introduction Myelodysplastic syndromes (MDS) encompass a diverse group of myeloid neoplasms for which the diagnosis low‐grade subtypes remains challenging. Erythroblastic islands (EBIs) are highly organized units erythroid proliferation, differentiation, and enucleation. EBI disruption is frequently observed believed to be one early changes in MDS. Methods In this study, we digitally analyzed bone marrow biopsies dual stained with alpha‐hemoglobin stabilizing protein (AHSP) CD163...
The present study was undertaken to investigate the relationship between apolipoprotein E genotype and cerebral palsy in Chinese Han children. 120 children with age range from 1 12 years old were selected as CP group including 86 spastic 34 dyskinetic children, normal control group. Apolipoprotein DNA obtained blood cell. Polymerase chain reaction‐restricted fragment length polymorphism (PCR‐RFLP) used determine allele severity of impairment assessed by gross motor function classification...
To compare the pharmaco-economic effect of 3 chemotherapeutic regimens in treatment patients with multiple myeloma(MM).One hundred and thirty-eight newly diagnosed cases MM our hospital were analyzed retrospectively, then divided into group A, B C according to therapeutic regimen. Group A was treated VCD regimen (bortezomib + cyclophosphamide dexamethasone, 63 cases), The BiCTD (clarithromycin+cyclophosphamide+thalidomide+dexamethasone, 44 CTD (cyclophosphamide+ thalidomide+dexamethasone, 33...