A5018124110- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Cancer therapeutics and mechanisms
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Head and Neck Surgical Oncology
- Chronic Myeloid Leukemia Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Myeloid Leukemia Research
- Gastrointestinal Tumor Research and Treatment
- Genomic variations and chromosomal abnormalities
- Cytomegalovirus and herpesvirus research
- Tumors and Oncological Cases
- Nonmelanoma Skin Cancer Studies
- Peptidase Inhibition and Analysis
- Acute Lymphoblastic Leukemia research
- Chemical Synthesis and Analysis
- Ovarian cancer diagnosis and treatment
- Eosinophilic Disorders and Syndromes
- Quinazolinone synthesis and applications
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Cancer Mechanisms and Therapy
Nanjing General Hospital of Nanjing Military Command
2015-2021
Nanjing University
2018-2019
Southern Medical University
2018
Second Hospital of Anhui Medical University
2018
Anhui Medical University
2018
Jinling Institute of Technology
2017
Clarithromycin (CAM) is a macrolide antibiotic that widely used in the treatment of respiratory tract infections, sexually transmitted diseases and infections caused by Helicobacter pylori Mycobacterium avium complex. Recent studies showed CAM was highly effective against multiple myeloma (MM) when combination with immunomodulatory drugs dexamethasone. However, related mechanism still unknown. As 3 agents are all respective regimen, we postulated might enhance effect drugs. We evaluated...
8p11 myeloproliferative syndrome (EMS) is a rare disease characterized by the constitutive activation of fibroblast growth factor receptor 1 (FGFR1). To date, four cases EMS with chromosomal translocation, t(1;8)(q25;p11.2), have been reported. In present study, TPR‑FGFR1‑expressing Baf3 cells were established and confirmed polymerase chain reaction. identify most promising drug for EMS, activities associated mechanism three tyrosine kinase inhibitors (TKIs), TKI258, ponatinib AZD4547,...
To investigate the clinicopathologic characteristics,diagnosis and treatment of isolated ovarian relapse acute lymphoblastic leukemia(ALL).A 16-year-old girl presented with complaints bone joint pain. The peripheral blood marrow(BM) smears showed 32% 72% blasts, respectively, which were myeloperoxidase-negative. blasts positive for HLA-DR, TdT, CD10, CD19, CD22 cCD79a negative CD34, CD5, CD7, CD13, CD33, CD56 MPO detected by flow cytometry. BM cytogenetic analysis fusion gene screening...
To investigate the clinicopathologic characteristics of adult patients with atypical infectious mononucleosis(IM).From January 2003 to December 2013, a total 5 cases IM misdiagnosed as lymphoma were selected, and clinico-pathological efficacy treatment analyzed. Biopsy lymph node or tonsil was performed evaluate possibility lymphoma. Peripheral blood EBV antibody EBV-DNA examined by ELISA real-time fluorescence quantitative PCR, respectively.All considered on basis morphological features in...
To investigate the clinicopathologic and molecular characteristics of acute promyelocytic leukemia(APL) developed during imatinib therapy for gastrointestinal stromal tumors(GIST).A 49-year-old woman was hospitalized abdominal pain. The CT revealed a gastric mass. Laparoscopic resection tumor performed. histopathologic analysis showed poorly differentiated malignant cell infiltration with epithelioid features. Immunohistochemistry staining these cells positive CD117 CD34. GIST confirmed...
To investigate the effects of bortezomib(BTZ) and thalidomide(TM) on peripheral blood memory T-cells (Tm) regulatory T cells(Tregs) in patients with multiple myeloma(MM).Eighty-six MM received 2 courses chemotherapy were divided into effective (partial response at least) group (63 cases) ineffective (no partial response) (17 according to therapeutic efficacy; these 80 BTZ (38 TM (42 yet regimens, 20 newly diagnosed used as baseline group, 30 healthy volunteers control group. The Tm subsets...
Objective To investigate the clinicopathologic characteristics, diagnosis and therapy of aggressive natural killer cell leukemia (ANKL) patients. Methods Clinical manifestations, cellular morphology, immunophenotypic analysis by flow cytometry (FCM), TCR gene rearrangement, pathology Immunohistochemical bone marrow (BM) were combined to diagnose six patients with ANKL. Results The median age 35.5 years old. All fever, cytopenia liver dysfunction. Imageological examination presented...
To investigate the cytogenetic characteristics of various plasma cell dyscrasia using CD138 MACS-FISH, to elucidate application value MACS-FISH in genetic diagnosis dyscrasia, and explore standardization FISH detection for dyscrasia.A total 232 patients with newly diagnosed were collected, including 203 cases MM, 24 AL amyloidosis 5 MGUS, whose abnormalities detected by differences positive rates chromosome karyotype analysis, C-FISH MM abnormality compared. The sensitivity analyzed compared...
To investigate the clinical, morphologic and immunophenotypic properties of patients with small cell variant T-cell prolymphocytic leukaemia(T-PLL).Peripheral blood bone marrow cytomorphologic examination, receptor(TCR) gene rearrangement detection were used to verify diagnosis for 2 lymphocytosis. Two treated combined chemotherapeutic protocol based on fludarabine.At case 1, main lymphocytes peripheral smear mature without nucleoli. The immunophenotype cells was CD3+CD5+CD7+CD4+CD8+TCRα/β+....
To establish a multiple myeloma specimen bank applied for molecular biological researches and to explore the methods of collection, transportation, storage, quality control management bank.Bone marrow blood samples were collected from patients, plasma cell sorting operated after separation mononuclear cells bone specimens. The divided into 2 parts, one was added with proper amount TRIzol then kept in -80 °C refrigerator subsequent RNA extraction, other calf serum frozen liquid...
To compare the pharmaco-economic effect of 3 chemotherapeutic regimens in treatment patients with multiple myeloma(MM).One hundred and thirty-eight newly diagnosed cases MM our hospital were analyzed retrospectively, then divided into group A, B C according to therapeutic regimen. Group A was treated VCD regimen (bortezomib + cyclophosphamide dexamethasone, 63 cases), The BiCTD (clarithromycin+cyclophosphamide+thalidomide+dexamethasone, 44 CTD (cyclophosphamide+ thalidomide+dexamethasone, 33...
Objective:To investigate the clinical features, diagnosis and treatment experience of basal cell adenoma (BCA).Method:The data 7 patients with parotid gland from Second Affiliated Hospital Medical University Anhui March 2012 to June 2016 were retrospectively analyzed. Combined literature review, was discussed.Result:Seven BCA mostly diagnosed as pleomorphic adenomatous lymphoma before operation using ultrasound, fine needle aspiration cytology enhanced CT, no prior operation. Four cases BCA,...
Abstract Objective: To explore potential predictors of RMPP in early stage. Study design: The prospective study, multicenter study was conducted Zhejiang, China from May 1 st , 2019 to January 31 2020. Children aged 29 days 14 years old, with fever time during 48 120 hours were included. A total 1428 children completed the study. questionnaire designed collect patients’ information. Pharyngeal swab samples collected. M. pneumoniae DNA pharyngeal specimens detected. Whether patients develop...