A5027771886- PARP inhibition in cancer therapy
- Multiple Myeloma Research and Treatments
- Ovarian cancer diagnosis and treatment
- Protein Degradation and Inhibitors
- Carbohydrate Chemistry and Synthesis
- Peptidase Inhibition and Analysis
- Synthetic Organic Chemistry Methods
- Cardiac, Anesthesia and Surgical Outcomes
- Glycosylation and Glycoproteins Research
- Lymphoma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroendocrine Tumor Research Advances
- DNA Repair Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Catalytic Processes in Materials Science
- Traditional Chinese Medicine Studies
- BRCA gene mutations in cancer
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Anesthesia and Sedative Agents
- Asymmetric Synthesis and Catalysis
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Nausea and vomiting management
- Advanced Differential Geometry Research
Nanjing Medical University
2010-2025
Jiangsu Province Hospital
2017-2024
Second Hospital of Anhui Medical University
2022-2024
Anhui Medical University
2022-2024
Central South University
2024
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2023-2024
Zhengzhou University
2024
University of York
2024
University of Shanghai for Science and Technology
2011-2023
Aims Propofol may result in hypotension, bradycardia and loss of protective reflexes, especially elderly patients, while esketamine, a N‐methyl‐D‐aspartate receptor antagonist, has analgesic, anaesthetic sympathomimetic properties is known to cause less cardiorespiratory depression. We hypothesized that esketamine reduce the median effective concentration (EC 50 ) propofol coadministration likely produce hypotension during gastrointestinal endoscopy patients. Methods Ninety aged 65–89 years,...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynergistic Formation of Soluble Lectin Clusters by a Templated Multivalent Saccharide LigandSteven D. Burke, Qian Zhao, Michael C. Schuster, and Laura L. KiesslingView Author Information Department Chemistry, University Wisconsin-Madison Madison, Wisconsin 53706 Cite this: J. Am. Chem. Soc. 2000, 122, 18, 4518–4519Publication Date (Web):April 22, 2000Publication History Received5 January 2000Published online22 April inissue 1 May...
Homologous recombination deficiency (HRD) is an approved predictive biomarker for Poly (ADP-ribose) polymerase inhibitors (PARPi) in ovarian cancer. However, the proportion of positive HRD real world and relationship between status PARPi Chinese cancer patients remain unknown. A total 67 who underwent PARPi, either olaparib or niraparib, were enrolled passed inclusion criteria from August 2018 to January 2021 Affiliated Cancer Hospital Nanjing Medical University. correlation with...
Primary hepatic neuroendocrine neoplasms (PHNENs) represent a kind of rare liver tumor and its clinical features prognosis remain unclear. This study aims to reveal the long-term therapeutic outcome PHNEN present prognostic feature. A retrospective designed, single-center containing 22 patients with PHNENs receiving surgical resections was done. Clinical data were reviewed follow-up updated. Survival analysis tried find factors. Nine recurred (recurrence rate = 40.9%) 6 died on disease. The...
Aims No consensus regarding the optimal endoscopic resection approach for rectal neuroendocrine tumors (R-NETs) measuring 10-20 mm, this study aims to investigate issue. Methods Patients with R-NETs underwent either mucosal (EMR) or submucosal dissection (ESD). The primary endpoint was complete rate, and secondary endpoints were surgery-related complications long-term outcomes. Results 96 patients met inclusion criteria, 84 completed resection, 5 excluded. 79 enrolled divided into EMR (n =...
Autophagy is an important regulator of cellular homeostasis and its dysregulation often results in cancer. Aberrant glycosylation induced by oncogenic transformation contributes to tumor invasion metastasis. In a previous study, we have demonstrated that EpCAM, protein, associated with cell growth metastasis breast But the effect EpCAM on autophagy not clear. precise mechanism regulation remains largely unknown. this cancer cells were transfected N-glycosylation mutation plasmid express...
Diabetes can increase the risk of coronary heart disease, and also mortality rate disease in diabetic patients. Although reperfusion therapy preserve viable myocardium, fatal injury occur. Studies have shown that diabetes aggravate myocardial ischemia-reperfusion injury, ERK1/2 reduce but its mechanism hyperglycemic is unclear. This study sought to explore extracellular signal-regulated kinase 1/2 (ERK1/2) ischemia (I/R) injury.H9C2 cardiomyocytes were treated with high-glucose (HG) medium...
BACKGROUND Traumatic head injury is a leading cause of death and disability worldwide. How clinicopathological features differ by age remains unclear. This epidemiological study analyzed the patients with belonging to 3 groups. MATERIAL AND METHODS Data traumatic were obtained from Department Cerebral Surgery Affiliated Hospital Guizhou Medical University Provincial People's in 2011-2015. Their parameters assessed. The divided into groups: elderly (≥65 years), middle-aged (18-64 juvenile...
Abstract Multiple myeloma (MM) is a highly heterogeneous and incurable disease. Inflammation plays vital role in cancer genesis progression. However, the relationship between inflammatory response-related genes (IRRGs) prognosis of MM patients remains unknown. We constructed IRRGs model by least absolute shrinkage selection operator regression analysis. Moreover, clinical multivariate was performed to identify implications. Gene set enrichment analysis implemented conduct its biological...
The study aimed to investigate the interaction of intraoperative stress hyperglycemia with monocyte functions and their impact on major adverse events (MAEs) in acute aortic dissection (AAD) patients who underwent open repair surgery.
Abstract Background Niraparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, is approved for first/second-line maintenance treatment of ovarian cancer patients with complete or partial response to platinum-based chemotherapy, and multi-line monotherapy in BRCAmt platinum-sensitive recurrence homologous recombination deficiency (HRD). We present real-world experience from single center China. Methods Patients treated niraparib Jiangsu Cancer Hospital between June 2019 July 2020 were...
PARP inhibitor (PARPi) is an important progress in ovarian cancer treatment. The available evidence suggests that BRCA mutation and homologous recombination deficiency (HRD) are effective biological markers for PARPi. Here we investigated the relationship between adverse events (AEs) efficacy of PARPi patients.Seventy-eight patients with underwent Olaparib Niraparib from July 2018 to 2020 were analyzed. AEs assessed by National Cancer Institute Common Terminology Criteria Adverse Events (NCI...
Sodium cantharidate (SCA) is a derivative of cantharidin obtained by its reaction with alkali. Studies have shown that it inhibits the occurrence and progression several cancers. However, therapeutic effects SCA on breast cancer are less well studied. This study aimed to clarify effect cells mechanism, provide scientific basis for clinical use treatment cancer. The results cell counting kit-8, colony formation assay, 5-ethynyl-2'-deoxyuridine staining showed inhibited proliferation....
// Feng Li 1, 2 , Yong-Ping Zhai Ting Lai Qian Zhao Hui Zhang 1 Yu-Mei Tang and Jian Hou Myeloma Lymphoma Center, Department of Hematology, Changzheng Hospital, The Second Military Medical University, Shanghai, China Jinling School Medicine, Nanjing Nanjing, Correspondence to: Hou, email: houjian@medmail.com.cn Keywords: t(4;14) translocation, MMSET gene, major breakpoint (MB4), prognosis, bortezomib Received: March 08, 2017 Accepted: May 06, Published: 24, ABSTRACT Multiple myeloma (MM)...
Modular syntheses of C3-symmetric macrocycles with pendant aryl and hydroxymethyl groups are described. These functional groups, amenable to further elaboration, were installed early in each synthesis carried through an iterative sequence module coupling macrolactonization. Association constants for macrolides 1a−c alkali metal cation guests determined, sandwich-type complexes Ba2+ confirmed these based on 1H NMR studies, including Job plots. X-ray crystallographic data 1a 1c obtained...
Abstract Efficient access to medicinally significant natural products is an essential basis for the development of pharmaceuticals. The limited availability marine impedes broad biological evaluation. Despite several elegant syntheses (−)‐lasonolide A having been reported, a practical synthesis this potent anticancer polyketide remains elusive. Based on application borane as traceless protecting group and unprecedented bissulfone reagent Julia olefination, was assembled in enantioconvergent...