A5100423168- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Organ Transplantation Techniques and Outcomes
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cancer Research and Treatments
- Liver Disease and Transplantation
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- MicroRNA in disease regulation
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
Second Affiliated Hospital of Zhejiang University
2016-2025
Shanghai Jiao Tong University
2018-2025
Tianjin Medical University Cancer Institute and Hospital
2025
Zhejiang University
2011-2024
First Affiliated Hospital Zhejiang University
2004-2024
Temple University
2022-2024
Central South University
2021-2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Shandong Tumor Hospital
2023
Aim: Sirtuin3 (sirt3) plays a pivotal role in improving oxidative stress and mitochondrial dysfunction which directly induced neuronal apoptosis after intracerebral hemorrhage (ICH). Reactive oxygen species (ROS) is also critical activator triggering NACHT, LRR, PYD domains-containing protein 3 (NLRP3) inflammasomes activation can regulate inflammatory responses brain. Moreover, hyperglycemia aggravate the ICH-induced damage. Hence, this study was designed to investigate mechanisms of...
Abstract Introduction Bone marrow mesenchymal stem cells (BMMSCs) have been reported to facilitate liver regeneration after toxic injuries. However, the effect of BMMSCs on massive hepatectomy is barely studied. Here we explored whether infusion promotes in a rat model. Methods Hypoxia preconditioning was achieved by culturing under hypoxia environment. Then 85% performed and or normoxia preconditioned were infused into portal vein. A group rats received vascular endothelial growth factor...
Abstract Background Intracerebral hemorrhage (ICH) can induce excessive accumulation of reactive oxygen species (ROS) that may subsequently cause severe white matter injury. The process oligodendrocyte progenitor cell (OPC) differentiation is orchestrated by microglia and astrocytes, ROS also drives the activation astrocytes. In light potent scavenging capacity ceria nanoparticles (CeNP), we aimed to investigate whether treatment with CeNP ameliorates injury modulating ROS-induced microglial...
Background: Venous bleeding induced by intercavernous sinus injury during sellar dural opening is a challenging intraoperative complication and difficult to treat in transsphenoidal surgery. To date, few studies concerning the management of have been reported. Aims: Our aim was assess clinical outcomes new hemostasis technique utilizing nonpenetrating titanium clips for bleeding. Materials Methods: From January 2007 July 2008, 242 pituitary tumors were operated using transnasal approach. A...
Traumatic brain injury (TBI) initiates a complex cascade of neurochemical and signaling changes that leads to neuronal apoptosis, which contributes poor outcomes for patients with TBI. The neuron-specific K(+) -Cl(-) cotransporter-2 (KCC2), the principal Cl(-) extruder in adult neurons, plays an important role homeostasis function. This present study was designed investigate expression pattern KCC2 following TBI evaluate whether or not melatonin is able prevent apoptosis by modulating...
The role of glial scar after intracerebral hemorrhage (ICH) remains unclear. This study aimed to investigate whether microglia-astrocyte interaction affects formation and explore the specific function scar. We used a pharmacologic approach induce microglial depletion during different ICH stages examine how ablating microglia astrocytic formation. Spatial transcriptomics (ST) analysis was performed potential ligand-receptor pair in modulation verify functional changes scars at periods. During...
Preclinical and clinical studies have shown that microglia macrophages participate in a multiphasic brain damage repair process following intracerebral hemorrhage. The E26 transformation-specific sequence-related transcription factor Spi1 regulates microglial/macrophage commitment maturation. However, the effect of on hemorrhage remains unclear. In this study, we found may regulate recovery from neuroinflammation neurofunctional caused by modulating transcriptome. We showed high expression...
Compelling evidence has indicated that imbalance between apoptosis and autophagy may be involved in subarachnoid hemorrhage (SAH). We aimed to investigate the effects mechanisms of melatonin homeostasis autophagy. One-hundred forty-eight male Sprague-Dawley rats were intraperitoneally injected with or vehicle 2 h after SAH induction. Western blotting an immunofluorescent assay performed detect expression apoptosis- autophagy-related proteins. The neuroprotective effect attenuating...
Background and Aims: The aim is to evaluate the association between use of intraoperative dexmedetomidine with an increase in recurrence-free survival (RFS) overall (OS) after nonsmall cell lung cancer (NSCLC) surgery. Material Methods: This was a propensity score-matched (PSM) retrospective study. Single academic center. study comprised patients Stage I through IIIa NSCLC. Patients were excluded if they younger than 18 years. Primary outcomes RFS OS. OS evaluated using univariate...
Abstract Background: Cavernous sinus dural arteriovenous fistulas (CS-DAVFs) present significant treatment challenges when the inferior petrosal (IPS) is not opacified during cerebral angiography. However, widely accepted transvenous IPS recanalization approach associated with a high failure rate. The consistently visible superior ophthalmic vein (SOV) offers promising alternative, though it has yet to be fully evaluated in large-scale studies. Methods: This retrospective, case-control study...
ABSTRACT Background The coagulation system is intrinsically linked to pathological mechanisms and progression of ischemic stroke. However, the role preoperative function in determining functional outcomes acute stroke patients following large artery occlusion (AIS‐LVO) has not been extensively evaluated peer‐reviewed literature. Methods We utilized logistic regression analyses, complemented by construction receiver operating characteristic (ROC) curves, identify significant predictive...
Implants made of titanium and its alloys are currently widely used in the human body. A series surface modification methods developed nowadays enable alloy implants to serve effectively body for a long time. This paper reviews three different types technologies biomedical alloys: physical, chemical, biological, with particular attention assistance these on biological properties alloys. The physical method can change morphology prepare specific coatings implants, such as oxide films,...
To sum up the clinical characteristics of patients with central pontine myelinolysis (CPM) after orthotopic liver transplantation (OLT) and to document possible causes CPM.Data 142 undergoing OLT between January 1999 May 2003 were analyzed retrospectively. Following risk factors during perioperation in without CPM: primary disease, preoperative serum sodium level, magnesium level plasma osmolality, fluctuation degree concentration, immunosuppressive drug etc.A total 13 (9.2%) neurologic...
pp32 is a nuclear protein found highly expressed in normal tissues those cells capable of self-renewal and neoplastic cells. We report the cloning cDNAs encoding human murine pp32. The clones encode 28.6-kDa protein; approximately two-thirds N-terminal predicts an amphipathic alpha helix containing two possible localization signals potential leucine zipper motif. C-terminal third exceptionally acidic, comprised 70% aspartic glutamic acid residues; predicted pI 3.81. Human are 88% identical;...
Neuronal apoptosis plays a key role in secondary brain injury caused by intracerebral hemorrhage (ICH). This study first showed that inhibition of activating transcription factor 6 (ATF6) could alleviate through anti-apoptosis after ICH rats. The melatonin, ATF6 and CCAAT/enhancer-binding protein homologous (CHOP) siRNAs were applied this study. Brain water content, behavioral assessment, blood-brain barrier (BBB) leakage evaluated at 24h ICH. Western blot analysis was used to evaluate the...