A5007768081- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Optical Imaging and Spectroscopy Techniques
- MicroRNA in disease regulation
- EEG and Brain-Computer Interfaces
- ECG Monitoring and Analysis
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Healthcare Technology and Patient Monitoring
- Cancer Cells and Metastasis
- Analytical Chemistry and Sensors
- Autophagy in Disease and Therapy
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Angiogenesis and VEGF in Cancer
- Cancer Mechanisms and Therapy
- Assistive Technology in Communication and Mobility
- Cardiovascular Health and Disease Prevention
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- Biosensors and Analytical Detection
- Photoacoustic and Ultrasonic Imaging
Air Force Medical University
2013-2025
Xijing Hospital
2013-2025
Chinese Academy of Sciences
2025
Ningbo Institute of Industrial Technology
2025
Huzhou University
2025
Second Affiliated Hospital of Zhejiang University
2025
Loughborough University
2015-2024
National Clinical Research Center for Digestive Diseases
2018-2024
Hubei University of Technology
2024
FilmLight (United Kingdom)
2024
This paper presents the design, theoretical modelling and experimental validation of a quad-stable energy harvester for harnessing ultra-low frequency random motions using nonlinear pendulum piezoelectric transduction. The multi-stable is created by magnetic forces between magnets on tip magnet cantilever beam. Two attractive one repulsive in combination with gravitational force create multiple stable positions pendulum. dynamics allow to effectively convert low-frequency kinetic from host,...
An amalgamated concept of Internet m-health Things (m-IoT) has been introduced recently and defined as a new that matches the functionalities IoT for innovative future (4G health) applications. It is well know diabetes major chronic disease problem worldwide with economic social impact. To-date there have not any studies address potential m-IoT non-invasive glucose level sensing advanced opto-physiological assessment technique management. In this paper we benefits using in based architecture...
Noncontact imaging photoplethysmography (PPG) can provide physiological assessment at various anatomical locations with no discomfort to the patient. However, most previous PPG (iPPG) systems have been limited by a low sample frequency, which restricts their use clinically, for instance, in of pulse rate variability (PRV). In present study, plethysmographic signals are remotely captured via an iPPG system 200 fps. The parameters (i.e., heart and respiration PRV) derived from datasets yield...
The MYC oncogene is overexpressed in hepatocellular carcinoma (HCC) and has been associated with widespread microRNA (miRNA) repression; however, the underlying mechanisms are largely unknown. Here, we report that c-Myc oncogenic transcription factor physically interacts enhancer of zeste homolog 2 (EZH2), a core enzymatic unit polycomb repressive complex (PRC2). Furthermore, miR-101, an important tumor-suppressive miRNA human hepatocarcinomas, epigenetically repressed by PRC2 c-Myc-mediated...
Imaging photoplethysmography (PPG) is able to capture useful physiological data remotely from a wide range of anatomical locations. Recent imaging PPG studies have concentrated on two broad research directions involving either high-performance cameras and or webcam-based systems. However, little has been reported about the difference between these techniques, particularly in terms their performance under illumination with ambient light. We explore approaches through simultaneous measurement...
Advanced colorectal cancer (CRC) is one of the deadliest cancers, and 5-year survival rate patients with metastasis extremely low. The epithelial–mesenchymal transition (EMT) considered essential for metastatic CRC, but fundamental molecular basis underlying this effect remains unknown. Here, we identified that O-GlcNAcylation, a unique posttranslational modification (PTM) involved in metabolic reprogramming, increased capability CRC. levels O-GlcNAcylation were CRC tissues cell lines, which...
Human gastric cancers contain a population of cancer stem cells (GCSCs) that can undergo self-renewal and multipotent differentiation. GCSCs be enriched with EpCAM+/CD44+ cells. However, the underlying mechanisms controlling balance GCSC differentiation remain to explored. Because miRNAs regulate cell fates, we compared miRNA expression in tumorspheric more differentiated We found miR-17-92 cluster members miR-19b, miR-20a miR-92a were gradually reduced during GCSCs. Therefore, speculated...
LAMP2A is the key protein of chaperone-mediated autophagy (CMA), downregulation leads to CMA blockade. activation has been implicated in cancer growth, but exact mechanisms are unclear. Elevated expression was found 8 kinds tumors (n=747), suggesting that may have an important role progression. Unsurprisingly, knockdown gastric (GC) cells hindered proliferation, accompanied with altered cell cycle-related proteins and accumulation RND3/RhoE. Interactomic KEGG analysis revealed RND3 a...
Background: Cancer-associated fibroblasts (CAFs) promote tumor progression through extracellular matrix (ECM) remodeling and extensive communication with other cells in microenvironment. However, most CAF-targeting strategies failed clinical trials due to the heterogeneity of CAFs. Hence, we aimed identify cluster tumor-promoting CAFs, elucidate their function determine specific membrane markers ensure precise targeting. Methods: We integrated multiple single-cell RNA sequencing (scRNA-seq)...
MicroRNAs play essential roles in gene expression regulation during carcinogenesis. Here, we investigated the role of miR-7 and mechanism by which it is dysregulated gastric cancer (GC). We used genome-wide screenings identified RELA FOS as novel targets miR-7. Overexpression repressed prevented GC cell proliferation tumorigenesis. These effects were clinically relevant, low was correlated with high poor survival patients. Intriguingly, found that indirectly regulated activation targeting...
Circulating tumor cells (CTCs) have emerged as promising tools for noninvasive cancer detection and prognosis. Most conventional approaches capturing CTCs use an EpCAM-based enrichment strategy, which does not work well in cancers that show low or no expression of EpCAM, such renal cell carcinoma (RCC). In this study, we developed a new set surface markers including CA9 CD147 alternative CTC-capture antigens specifically designed RCC patients. We showed the both was prevalent patient cohort...
Loss of cell-cell adhesion is important for the development cancer invasion and metastasis. Vinculin, a key adhesion-related protein, can affect metastasis prognosis in several tumours. Here, we determined biological roles vinculin colorectal (CRC) evaluated its clinical significance as potential disease biomarker. The expression level CRC cell lines tissues was measured using Real-Time PCR western blotting. Moreover, function analysed Transwell assays vivo gain- loss-of-function...
Abstract The Chinese natural product, berberine, has biological properties that support its potential efficacy as a colon cancer prevention agent. Its longstanding use in China to treat gastrointestinal tract and rheumatologic disorders is generally regarded safe, supporting initial investigations an at-risk population, such individuals with ulcerative colitis. However, the safety of berberine this population not established. Individuals living biopsy-proven colitis, ≤grade 2 dysplasia,...
Contact and spot measurement have limited the application of photoplethysmography (PPG), thus an imaging PPG system comprising a digital CMOS camera three wavelength light-emitting diodes (LEDs) is developed to detect blood perfusion in tissue. With means system, ideally contactless monitoring with larger field view different depth tissue by applying multi- illumination can be achieved understand change. Corresponding individual LED illumination, signals derived both transmission reflection...
Aberrant upregulation of POU2F2 expression has been discovered in metastatic gastric cancer (GC). However, the mechanisms underlying aberrant and potential functions remain uncertain.The role mechanism GC metastasis were investigated epithelial cells, cell lines an experimental animal model by gain function loss function. Upstream downstream targets selected bioinformatics identified luciferase reporter assay, electrophoretic mobility shift assay chromatin immunoprecipitation PCR. The...
Heart rate (HR) as an important physiological indicator could properly describe global subject’s physical status. Photoplethysmographic (PPG) sensors are catching on in field of wearable sensors, combining the advantages costs, weight and size. Nevertheless, accuracy HR readings is unreliable specifically during activity. Among several identified sources that affect PPG recording, contact pressure (CP) between sensor skin greatly influences signals. Methods: In this study, measurements a at...
Background: Metastasis is the major reason for high recurrence rates and poor survival among patients with colorectal cancer (CRC). However, underlying molecular mechanism of CRC metastasis unclear. This study aimed to investigate role forkhead box K2 (FOXK2), one most markedly increased FOX genes in CRC, by which it deregulated metastasis. Methods: FOXK2 levels were analyzed two independent human cohorts (cohort I, n = 363; cohort II, 390). In vitro Transwell assays vivo lung liver models...
A novel bilayer resist system consisting of a 3 nm thick titanium (Ti) layer on top 65 poly(methylmethacrylate) (PMMA) was developed for mechanical nanolithography with the atomic force microscope. The ultrathin Ti allowed 20 resolution patterning conventional silicon cantilevers, provided proper force-depth calibration performed before lithography. Techniques pattern transfer were applied to fabricate chromium nanostructures and nanowires from patterned Ti/PMMA resist.
Poor cell survival severely limits the beneficial effects of stem therapy for peripheral arterial disease (PAD). This study was designed to investigate role mammalian target rapamycin (mTOR) in and therapeutic function transplanted murine adipose-derived stromal cells (mADSCs) a PAD model. mADSCs (1.0 × 10(7)) were isolated from dual-reporter firefly luciferase enhanced green fluorescent protein-positive transgenic mice, intramuscularly implanted into hind limb C57BL/6 mice after femoral...
This study presents the use of a multi-channel opto-electronic sensor (OEPS) to effectively monitor critical physiological parameters whilst preventing motion artefact as increasingly demanded by personal healthcare. The aim this work was how capture heart rate (HR) efficiently through well-constructed OEPS and 3-axis accelerometer with wireless communication. A protocol designed incorporate sitting, standing, walking, running cycling. datasets collected from these activities were processed...
The aim of the present study was to delineate therapeutic effect a Helicobacter pylori vaccine with chitosan as an adjuvant, well identify potential mechanism against H. infection when compared vaccine, cholera toxin (CT) adjuvant. Mice were first infected and, following establishment effective model, vaccinated using protein Levels colonization, pylori‑specific antibodies and cytokines determined by enzyme‑linked immunosorbent assay. TLR4 Foxp3 mRNA levels reverse transcription polymerase...
A novel refractive index (RI) sensor based on microfiber (MF) coated with gold nanowires has been proposed and theoretically investigated. Compared film, the can significantly improve performance of MF sensor. The influence diameters nanowire sensing properties are For analyte RI ns = 1.33, maximum sensitivity 5200nm/RIU (DMF 3μm, Dwire 120nm) figure merit (FOM) 150.38RIU−1 9μm, 30nm) be achieved. Both FOM will increase when increases from 1.33 to 1.40. 1.40, an extremely high 12314nm/RIU...