A5101478861- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Water Systems and Optimization
- IgG4-Related and Inflammatory Diseases
- Infant Health and Development
- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Prostate Cancer Treatment and Research
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Sirtuins and Resveratrol in Medicine
- Amyotrophic Lateral Sclerosis Research
Beijing Friendship Hospital
2023-2025
Capital Medical University
2023-2025
University of Nevada, Las Vegas
2024
Hebei Medical University
2023
Second Hospital of Hebei Medical University
2023
National Clinical Research Center for Digestive Diseases
2017-2023
Guangxi Medical University
2022
Air Force Medical University
2017-2020
Xijing Hospital
2017-2020
Ministry of Ecology and Environment
2020
Abstract The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the of SOX12 mechanism by which it is dysregulated colorectal (CRC) remain unclear. Here we analyzed expression patterns two independent CRC cohorts (cohort I, n = 390; cohort II, 363) found that was significantly upregulated CRC, indicating poor prognosis patients. Overexpression promoted cell proliferation metastasis, whereas downregulation hampered...
Colorectal cancer (CRC) frequently harbors KRAS mutations that result in chemoresistance and metastasis. MicroRNAs (miRNAs) are usually dysregulated play important regulatory roles tumor progression. However, the mutation-responsive miRNA profile CRC remains uninvestigated.
Background: Metastasis is the major reason for high recurrence rates and poor survival among patients with colorectal cancer (CRC). However, underlying molecular mechanism of CRC metastasis unclear. This study aimed to investigate role forkhead box K2 (FOXK2), one most markedly increased FOX genes in CRC, by which it deregulated metastasis. Methods: FOXK2 levels were analyzed two independent human cohorts (cohort I, n = 363; cohort II, 390). In vitro Transwell assays vivo lung liver models...
Metastasis is the major cause of poor survival and therapeutic failure in gastric cancer (GC). However, molecular mechanisms underlying GC metastasis remain unclear. Here, we analyzed expression patterns sex determining region Y-box 12 (SOX12) two independent cohorts paired tissues adjacent nontumor conducted vitro vivo functional studies to determine role SOX12 cells. High was associated with increased frequency recurrence poorer patient survival. overexpression cell migration, invasion...
A 54-year-old man presented to our department with a 2-month history of back pain and painful urination. contrast-enhanced computed tomography (CT) revealed large retroperitoneal soft tissue mass encircling the abdominal aorta, surrounding vessels, right ureter ([Fig. 1]). He had an average leukocyte level (7300/µL), within normal range for tumor markers IgG4 levels, C-reactive protein 38.88 mg/L. The clinical picture was highly suggestive fibrosis (RPF); however, definite diagnosis, biopsy...
Proximal migration of a pancreatic stent is rare complication endoscopic retrograde cholangiopancreatography (ERCP), with an incidence approximately 5.2% [1]. This constitutes dire scenario, as it may cause damage to the duct, potentially necessitating surgical intervention. We describe case successful retrieval proximally migrated using basket in roomy ampulla Vater duodenal diverticula.
Abstract The aberrant expression of human sirtuin 2 (SIRT2) has been detected in various types cancer; however, the biological roles, underlying mechanisms and clinical significance SIRT2 dysregulation colorectal cancer (CRC) remain unclear. results this study demonstrate that compared with paired normal tissues, is significantly decreased CRC tissues. loss correlated clinicopathological characteristics, including distant metastasis, lymph node metastasis American Joint Committee on Cancer...
Gout is one of the most prevalent rheumatic diseases, globally. Colchicine (COL) first-line drug used for treatment acute gout. However, oral administration COL restricted, owing to serious adverse reactions. Therefore, this study aimed develop a drug-in-adhesive (DIA) patch achieve transdermal delivery COL. We investigated solubility in different pressure-sensitive adhesives (PSAs) using slide crystallization studies. The COL-DIA patches were optimized based on vitro skin penetration...
Introduction Amyotrophic lateral sclerosis (ALS) is a rare, devastating neurodegenerative disease that affects upper and lower motor neurons. To date, no effective treatment or reliable biomarker for ALS has been developed. In recent years, many factors have proposed as possible biomarkers of ALS; however, consensus reached. Therefore, urgently needed. Eosinophils may play crucial role in healthy humans diseases, serve chronic diseases. Methods Routine blood test results were collected from...
<title>Abstract</title> Gastric cancer (GC) relies heavily on the reprogramming of lipid metabolism for energy, growth, and survival. Apolipoprotein C-I (APOC1) is implicated in metabolic processes GC, yet precise molecular mechanisms underlying this association remain incompletely understood. In study, we identified APOC1 as a key player GC progression. Our findings show that upregulated tissues cells compared with controls correlated poor prognosis. Furthermore, overexpression promoted...
BackgroundColorectal cancer (CRC) is one of the most prevalent malignant tumors with high morbidity and mortality rates worldwide. ZNF274, a member zinc-finger-protein family transcription factors, critical in chromosomal remodelling tumorigenesis. However, role ZNF274 CRC underlying molecular mechanisms remain unclear.MethodsImmunohistochemical analysis was performed to quantify expression human tissues. The Kaplan‒Meier method used analyse relationship between prognosis. correlation...