A5102023988- Neuroscience and Neuropharmacology Research
- Advanced Fluorescence Microscopy Techniques
- Glycogen Storage Diseases and Myoclonus
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Anesthesia and Neurotoxicity Research
- Advanced biosensing and bioanalysis techniques
- GNSS positioning and interference
- Digital Holography and Microscopy
- Inertial Sensor and Navigation
- Orbital Angular Momentum in Optics
- Near-Field Optical Microscopy
- Intensive Care Unit Cognitive Disorders
- High-Temperature Coating Behaviors
- High Entropy Alloys Studies
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Optical Coherence Tomography Applications
- Geophysics and Gravity Measurements
- RNA Interference and Gene Delivery
- Functional Brain Connectivity Studies
- Dental Implant Techniques and Outcomes
- Intermetallics and Advanced Alloy Properties
- Mitochondrial Function and Pathology
- Advanced Frequency and Time Standards
Xijing Hospital
2016-2025
Air Force Medical University
2016-2025
Henan University of Technology
2024-2025
Shanxi University
2021-2022
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2021-2022
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2021-2022
Peking University
2017-2022
Ministry of Industry and Information Technology
2022
Beijing Institute of Technology
2022
Wuhan University of Technology
2020
Abstract The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the of SOX12 mechanism by which it is dysregulated colorectal (CRC) remain unclear. Here we analyzed expression patterns two independent CRC cohorts (cohort I, n = 390; cohort II, 363) found that was significantly upregulated CRC, indicating poor prognosis patients. Overexpression promoted cell proliferation metastasis, whereas downregulation hampered...
Astrocytic glycogen works as an essential energy reserve for surrounding neurons and is reported to accumulate excessively during cerebral ischemia/reperfusion (I/R) injury. Our previous study found that accumulated mobilization exhibits a neuroprotective effect against I/R damage. In addition, ischemia could transform astrocytes into A1-like (toxic) A2-like (protective) subtypes. However, the underlying mechanism behind mobilization-mediated neuroprotection in reperfusion injury its...
To investigate the current situation of mental psychology and quality life (QoL) in patients with inflammatory bowel disease (IBD) China, analyze influencing factors.
Astrocytic glycogen is an important energy reserve in the brain and believed to supply fuel during crisis. However, pattern of metabolism ischemic stroke its potential therapeutic impact on neurological outcomes are still unknown. Here, we found extensive accumulation after reperfusion patients primates. Glycogenolytic dysfunction astrocytes responsible for accumulation, caused by inactivation protein kinase A (PKA)-glycogen phosphorylase (PhK)-glycogen (GP) cascade accompanied activation...
Abstract Although antipsychotics that act via monoaminergic neurotransmitter modulation have considerable therapeutic effect, they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorders. This may be attributed to the limited range of neurotransmitters are regulated by psychotropic drugs. Recent findings indicate need for investigation medications target less-studied neurotransmitters. Among these candidate neurotransmitters, lactate is developing being a...
ABSTRACT Objective To establish the norms of Hong Kong Brief Cognitive Test (HKBC) among Chinese older adults and to examine its utility for differentiating neurocognitive disorders from cognitively normal controls. Methods Two thousand three hundred twelve participants aged 40 years above were recruited six regions China as norm construction sample. 93 246 cognitive impairment patients included diagnostic test HKBC. Based on multinomial regression model, which analyzed relationship between...
Abstract Al–0.6Mg–0.5Si (wt%) alloys with varying Y contents are prepared, and effects of on the microstructure, electrical conductivity, mechanical properties investigated. The results show that refined by addition Y, average grain size is from 254 to 168 μm content 0 0.4 wt%. Addition can lead formation AlSiY phase AlFeSiMgY mixed as react elements such Fe Si in alloy. conductivity initially increases subsequently decreases increasing content. reaches its highest value 54.3% IACS 0.3 wt%...
Japanese encephalitis virus (JEV) is the most prevalent cause of viral in Asia and western Pacific. Neuronal death caused by JEV infection inflammation induced cytotoxicity leads to progression deterioration (JE). Mixed-lineage kinase domain-like protein (MLKL) mediated necroptosis a newly discovered pathway programmed cell participates many inflammatory diseases. In this study, we demonstrated for first time that was involved neuronal loss during JE via immune-electron microscopy...
Astrocytic glycogen serves as an important glucose reserve, and its degradation provides extra support for neighboring neurons during energy deficiency. Salvianolic acid B (SAB) exerts a neuroprotective effect on reperfusion insult after cerebrovascular occlusion, but the of SAB astrocytic relationship with neuroprotection are not completely understood. Here, we knocked down astrocyte-specific phosphorylase (GP, rate-limiting enzyme in glycogenolysis) vitro vivo investigated changes key...
Glycophagy has evolved from an alternative glycogen degradation pathway into a multifaceted pivot to regulate cellular metabolic hemostasis in peripheral tissues. However, the pattern of glycophagy brain and its potential therapeutic impact on ischemic stroke remain unknown. Here, we observed that dysfunction astrocytic was caused by downregulation GABA type A receptor-associated protein like 1 (GABARAPL1) during reperfusion patients mice. PI3K-Akt activation is involved driving GABARAPL1...
Abstract Conventional light sheet fluorescence microscopy (LSFM) utilizes two perpendicularly arranged objective lenses for optical excitation and detection, respectively. Such a configuration often limits the use of high‐numerical‐aperture (NA) objectives or requires specially designed long‐working‐distance objectives. Here, LSFM based on micro‐mirror array (MMA) to enable imaging with single lens is reported. The planar fluorescent emission excited by illumination collected same objective,...
A cobalt metal-organic framework (Co MOF)-ionic liquid (IL) nanocomposite comprising the base matrix of electrode was developed with electropolymerized molecularly imprinted polymer (MIP) consisting o-phenylenediamine (oPD) to detect carcinoembryonic antigen (CEA), a biomarker breast cancer. Firstly, Co MOF synthesized using hydrothermal synthesis, which used as an electrically conductive skeleton and functionalized IL. Then, CEA employed template in electropolymerization oPD-imprinted films...
Background: It is well known that circadian rhythms and sleep homeostasis contribute to a pronounced trough in sleepiness behavioral performance at night. However, the underlying neuroimaging mechanisms remain unclear. How brain-function connectivity modulated during deprivation (SD) has been rarely examined. Methods: By increasing number of scanning sessions SD, current study used voxel-mirrored homotopic (VMHC) investigate dynamic changes interhemispheric communication one night SD. Every...
High failure rates of oral implants have been reported in diabetic patients due to the disruption osseointegration. The aim this study was investigate whether direct laser metal sintering (DLMS) could improve osseointegration animal models.Surface characterizations were carried out on two types implants. Cell morphology and osteogenic-related gene expression MG63 cells observed under conditions DLMS microarc oxidation (MAO). A diabetes model mini-pigs established by intravenous injection...
Schizophrenia (SCZ) is an inherited disease, with the familial risk being among most important factors when evaluating individual’s for SCZ. However, robust imaging biomarkers disease that can be used diagnosis and determination of prognosis are lacking. Here, we explore potential functional connectivity (FC) use as a biomarker early detection high-risk first-degree relatives (FDRs). Thirty-eight first-episode SCZ patients, 38 healthy controls (HCs), 33 FDRs were scanned using resting-state...
There are growing concerns that anaesthetic exposure can cause extensive apoptotic degeneration of neurons and the impairment normal synaptic development remodelling. However, little attention has been paid to exploring possible cytotoxicity inhalation anaesthetics, such as isoflurane, in astrocytes. In this research, we determined prolonged an caused astrocytes, identified underlying molecular mechanism responsible for process.Astrocytes were exposed astrocytic survival was then measured...
Fluorescence emission difference (FED) microscopy, as an emerging super-resolution imaging modality, uses double-exposure and subtraction between double-exposed fluorescence images to achieve high spatial resolution beyond the diffraction limit. Here we report on a new FED approach with single-exposure scheme based dynamic cylindrical-vector fields, where excitation beam can be switched radial azimuthal polarization states at designated radio frequency. Lateral of <mml:math...
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