A5101999329- Reproductive Biology and Fertility
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Pluripotent Stem Cells Research
- Retinal Imaging and Analysis
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Viral Infectious Diseases and Gene Expression in Insects
- Immunotherapy and Immune Responses
- Ophthalmology and Visual Impairment Studies
- RNA modifications and cancer
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- 3D Printing in Biomedical Research
- Sperm and Testicular Function
- Retinal Diseases and Treatments
- Covalent Organic Framework Applications
- Inflammatory Biomarkers in Disease Prognosis
- Autophagy in Disease and Therapy
- Esophageal Cancer Research and Treatment
- Surgical Sutures and Adhesives
- Nanoparticle-Based Drug Delivery
Zhejiang University
2018-2025
Sun Yat-sen University
2023-2025
Sir Run Run Shaw Hospital
2024-2025
Ministry of Industry and Information Technology
2024-2025
Beijing Institute of Technology
2024-2025
Third Affiliated Hospital of Harbin Medical University
2019-2024
Hong Kong Polytechnic University
2024
Soochow University
2006-2024
Stomatology Hospital
2021-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Abstract Severe traumatic bleeding may lead to extremely high mortality rates, and early intervention stop plays as a critical role in saving lives. However, rapid hemostasis deep non-compressible trauma using highly water-absorbent hydrogel, combined with strong tissue adhesion bionic procoagulant mechanism, remains challenge. In this study, DNA hydrogel (DNAgel) network composed of natural nucleic acids water absorption, swelling instant is reported, like band-aid physically bleeding. The...
Traumatic brain injury (TBI) can lead to different neurological and psychiatric disorders. Circular RNAs (circRNAs) are highly expressed in the nervous system enriched synapses; yet, underlying role mechanisms of circRNAs impairment dysfunction still not fully understood. In this study, we investigated expression their relation with after TBI. RNA-Seq was used detect differentially injured tissue, revealing that circIgfbp2 significantly increased. Up-regulated hsa_circ_0058195, which...
Abstract Systemic chemotherapy for oral squamous cell carcinoma (OSCC) is associated with multidrug resistance and systemic adverse effects. Cobalt‐ferrocene metal–organic framework (Co‐Fc) a nanoparticle synthetized by ferrocene cobalt stronger Fenton reaction that can locally generate hydroxyl radical effectively kill tumors. However, tumor cells remove exogenous substances through autophagy activity to maintain the internal environment homeostasis. Herein, Co‐Fc loaded classical inhibitor...
Abstract Autograft replaced by a nerve guidance conduit (NGC) is challenging in peripheral injury because current NGC still limited precise conductivity and excellent biocompatibility vivo, which influences the repair even for long lesion gap repair. Several particular elements have potential function acceleration based on traditional three factors of neural tissue engineering. The review aims to address questions: 1) What superior factor conduction application? 2) How can more conductive...
Objective: The purpose of our study is to investigate the role miR-17-5p in angiogenesis nasopharyngeal carcinoma and crosstalk between HUVECs CNE-2 via exosomes. Methods: Firstly, flow cytometry, cell viability assay, transwell tube formation were used explore angiogenesis. Then zebrafish model was confirm effects on qRT-PCR analysis Immunofluorescence assay expression NPC tissues cells compared normal control. Besides, vitro assays analyze biological functions NPC. What's more, vivo detect...
To investigate the relationship between body fat distribution and risk of cardiometabolic microvascular events among individuals with prediabetes or diabetes normal mass index (BMI).A total 17,232 participants from UK Biobank (UKB) 12-year follow-up 499 diabetic China 2-year BMI were included. Anthropometric measurements waist circumference (WC), waist-to-hip ratio (WHR) waist-to-height (WHtR), composition assessment trunk-to-leg (TLFR) obtained. Outcomes included incident all-cause...
Gastric cancer is the fourth most common and second leading cause of death worldwide. Cardiospermum halicacabum used to treat nerve disorders, stiffness, rheumatism, ear ache, snake bite, so on.In this study, reaction parameters were optimized control size nanoparticle, which was confirmed by transmission electron microscopy. Various characterization techniques such as selected area diffraction pattern, UV-visible spectroscopy, energy-dispersive X-ray analysis, dynamic light scattering,...
Aim: Achieving drug-targeting delivery and environment-responsive releasing to realize imaging-guided precise tumor therapy. Materials & methods: Graphene oxide (GO) was used as the drug-delivery system load indocyanine green (ICG) doxorubicin (DOX) form a GO/ICG&DOX nanoplatform, in which GO can quench fluorescence of ICG DOX. MnO2 folate acid-functionalized erythrocyte membrane were further coated into surface obtain an FA-EM@MnO2-GO/ICG&DOX nanoplatform. Results: The nanoplatform has...
Purpose: To investigate the 10-year changes in visual function and incidence of impairment (VI) highly myopic eyes. Methods: This longitudinal study enrolled individuals who were followed up for 10 years. All participants underwent detailed ophthalmic examinations at baseline follow-up visits. Best-corrected acuity (BCVA) was measured using Early Treatment Diabetic Retinopathy Study protocol, field (VF) assessed with standard automatic perimetry. Results: A total 568 eyes (284 participants)...
Objectives: The present study identified the prognostic nutritional factors and their relationships with survival outcome in patients esophageal cancer treated chemoradiotherapy (CRT).Methods: A total of 97 previously CRT were enrolled study. status was assessed by Nutrition Risk Screening 2002 (NRS-2002). Weight, serum protein, albumin, prealbumin level, red blood cell, lymphocyte count, hemoglobin also recorded. index (PNI) calculated.Results: proportion at risk from baseline until sixth...
Abstract Phototherapy has been recognized as a photochemical process to treat tumor via induce cancer cells necrosis and death, with minimal invasiveness, higher selectivity, few side effects. However, the therapy effects of phototherapy are often compromised by hypoxia, high levels hydrogen peroxide, glutathione microenvironment (TME). Therefore, we constructed catalase-like activity bionic metal–organic framework drugs delivery system (FA-EM@MnO 2 /ZIF-8/ICG) controllable releasing. In...