Traumatic brain injury (TBI) can lead to disability or devastating consequences with few established treatments. Although ferroptosis has been shown be involved in TBI, the underlying mechanism was rarely known. Melatonin indicated exhibit neuroprotective activities. However, anti-ferroptotic effects of melatonin on TBI have not yet elucidated. We aimed investigate whether induced humans after and inhibition by could protect against blood-brain barrier (BBB) damage vivo vitro. Circular RNAs...

Traumatic brain injury (TBI) can lead to different neurological and psychiatric disorders. Circular RNAs (circRNAs) are highly expressed in the nervous system enriched synapses; yet, underlying role mechanisms of circRNAs impairment dysfunction still not fully understood. In this study, we investigated expression their relation with after TBI. RNA-Seq was used detect differentially injured tissue, revealing that circIgfbp2 significantly increased. Up-regulated hsa_circ_0058195, which...

Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) strongly predictive death by suicide, electroconvulsive therapy (ECT) effective for MDD, especially patients with SI. In present study, we aimed to determine differences resting-state functional magnetic resonance imaging (rs-fMRI) 14 adolescents aged 12-17 MDD SI at baseline after ECT. All participants were administered Hamilton Depression Scale (HAMD) Beck...

BACKGROUND Currently, adolescent depression is one of the most significant public health concerns, markedly influencing emotional, cognitive, and social maturation. Despite advancements in distinguish neurobiological substrates underlying depression, intricate patterns disrupted brain network connectivity adolescents warrant further exploration. AIM To elucidate neural correlates by examining using resting-state functional magnetic resonance imaging (rs-fMRI). METHODS The study cohort...

Major depressive disorder (MDD) and bipolar (BD) share clinical features, which complicates their differentiation in settings. This study proposes an innovative approach that integrates structural connectome analysis with machine learning models to discern individuals MDD from BD. High-resolution MRI images were obtained diagnosed or BD HCs. Structural connectomes constructed represent the complex interplay of brain regions using advanced graph theory techniques. Machine employed unique...

Non-suicidal self-injury (NSSI) behaviors are common in adolescents with major depressive disorder (MDD). Brain studies specifically targeting MDD and NSSI may provide new insights into suicide warnings MDD.This study examined the whole-brain neural activity aged between 12-17 years, 50 unmedicated patients (nsMDDs) or without (nnsMDDs), 25 healthy controls (HCs) participated this study, analyzed correlation values of amplitude low-frequency fluctuation (ALFF), fractional (fALFF) regional...

Prior research has demonstrated that the brains of adolescents with depression exhibit distinct structural alterations. However, preliminary studies have documented pathophysiological changes in certain brain regions, such as cerebellum, highlighting a need for further to support current understanding this disease.To study depressed adolescents.This enrolled 34 and age-, sex-, education-level-matched healthy control (HC) individuals. Structural functional alterations were identified when...

Background and Objective: The default mode network (DMN) may be an important component involved in the broad-scale cognitive problems seen patients with first-episode treatment-naive depression. Nevertheless, information is scarce regarding changes homogeneity (NH) found DMN of these patients. Therefore, this study, we explored NH Methods: study included 66 74 control participants matched by age, gender, educational level health status who underwent resting-state functional magnetic...

Resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the effects of electroconvulsive therapy (ECT) causing brain function changes in adolescents who suffered from depression and suicidal ideation (SI). A total 30 patients (MDDs) 25 healthy controls (HCs) matched by gender, age, education level were enrolled. The amplitude low-frequency fluctuations (ALFF) regional homogeneity (ReHo) compare differences between HCs MDDs at baseline, ALFF ReHo pre/post ECT...

Schizophrenia is a severe mental disorder with neurodevelopmental origin. Although schizophrenia results from changes in the brain, underlying biological mechanisms are unknown. Transcriptomics studies quantitative expression or qualitative of all genes and isoforms, providing more meaningful insight. Magnetic resonance imaging (MRI) techniques play roles revealing brain structure function. We give narrative focused review on current transcriptome combined MRI related to summarize research...

Background The neurobiological basis of suicidal behaviors among female adolescents with major depressive disorder (MDD) remains largely unclear. Materials and methods Fifty-eight drug-naïve, first-episode adolescent MDD [including 31 patients attempt (SA group) 27 without SA (non-SA group)], 36 matched healthy controls (HCs) participated in the present study. Resting-state functional magnetic resonance imaging (MRI) was performed on each subject. metrics amplitude low-frequency fluctuation...

Non-suicidal self-injury (NSSI) commonly occurs among adolescents with major depressive disorder (MDD), causing adverse effects on the physical and mental health of patients. However, underlying neurobiological mechanism NSSI in MDD (nsMDDs) remains unclear, there are still challenges treatment. Studies have suggested that sertraline administration could be an effective way for treatment.To verify effectiveness to explore processes, we treated a group nsMDDs this study. The brain spontaneous...

While electroconvulsive therapy (ECT) has been repeatedly shown to effectively and efficiently treat the major depressive disorder (MDD), mechanistic basis for such therapeutic efficacy remains be firmly established. As such, further research exploring ECT-based treatment of MDD in an adolescent population is warranted.This study included 30 treatment-naïve first-episode patients healthy control (HC) individuals (aged 12-17 years). All participants were scanned using rs-fMRI, again after 2...

Objects: The efficacy of electroconvulsive therapy (ECT) in the treatment adolescents with treatment-refractory depression is still unsatisfactory, and individual differences are large. It not clear which factors related to effect. Resting-state fMRI may be a good tool predict clinical this treatment, it helpful identify most suitable population for treatment. Methods: Forty were treated by ECT evaluated using HAMD BSSI scores before after then divided into response group non-treatment...

Introduction Adverse life events constitute primary risk factors for major depressive disorder (MDD), influencing brain function and structure. Adolescents, with their brains undergoing continuous development, are particularly susceptible to enduring impacts of adverse events. Methods We investigated differences correlations among childhood trauma, negative events, alterations in adolescents first-episode MDD. The study included 23 patients MDD 19 healthy controls, aged 10–19 years. All...

Background and Purpose The proportion of patients with somatic diseases associated anxiety is increasing each year, pulmonary nodules have become a non-negligible cause anxiety, the mechanism which unclear. study focus on cerebral blood flow (CBF) in to explore perfusion pattern nodules, status mode nodule induced state. Materials Methods Patients unconfirmed were evaluated by Hamilton Anxiety Scale (HAMA). total score > 14 was defined as group, ≤ points non-anxiety group. A 38...

The use of antidepressant therapy alone has a limited efficacy in patients with childhood trauma-associated major depressive disorder (MDD). However, the effectiveness treatment combined psychodrama these is unclear.To evaluate psychodrama.Patients MDD treated antidepressants were randomly assigned to either intervention (observation group) or general health education (control and received combination for 6 mo. observation group given by investigator together "semi-structured model" Yi Shu...

Purpose The major depressive disorder (MDD) can be a threat to the health of people all over world. Although governments have developed and implemented evidence-based interventions prevention programs prevent MDD maintain mental in adolescents, number adolescents with this condition has been on rise for past 10 years. Methods A total 60 were recruited, including 32 drug-naive first-episode 28 healthy controls (HCs). Alterations intrinsic cerebral activity explored using arterial spin...

Objective We aimed to investigate changes in whole-brain gray matter volumes (GMVs) before and after electroconvulsive therapy (ECT) adolescents with major depressive disorder (MDD) suicidal ideation (SI). Methods Thirty MDD SI were observed, structural magnetic resonance imaging (sMRI) was performed at baseline ECT for each patient. But Twenty-five healthy controls (HCs) scanned only baseline. The voxel-based morphometry (VBM) techniques used examine GMVs. Results Compared HCs, MDDs showed...