A5101625460- Multiple Sclerosis Research Studies
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Alzheimer's disease research and treatments
- Genetic Mapping and Diversity in Plants and Animals
- Immune Cell Function and Interaction
- Wheat and Barley Genetics and Pathology
- Genetics and Plant Breeding
- Ginkgo biloba and Cashew Applications
- Dysphagia Assessment and Management
- Autoimmune Neurological Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Luminescence Properties of Advanced Materials
- Functional Brain Connectivity Studies
- Physical Activity and Health
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Screening and Detection
- Neurological Disease Mechanisms and Treatments
- Mineral Processing and Grinding
- Competency Development and Evaluation
- Ultrasound Imaging and Elastography
Shanghai Jiao Tong University
2018-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018-2024
Chongqing Medical University
2018-2024
Shanghai Ninth People's Hospital
2022-2024
Tianjin Medical University
2024
Fujian Normal University
2024
Fujian Institute of Research on the Structure of Matter
2024
Chinese Academy of Sciences
2024
XinHua Hospital
2021-2023
Ruijin Hospital
2019-2022
Abstract Scintillators with high light yield, spatial resolution, and detection sensitivity are desirable for X‐ray imaging. Howerer, it remains challenging to improve the yield radiation capability of alkali metal rare‐earth fluoride (ALnF 4 ). Herein, a type Cu 2+ ion heterovalent co‐doped LiLuF :Tb,Cu microcrystalline scintillation material persistent, thermostimulated luminescence is obtained by defect engineering. The codoping strategy not only increases radioluminescence (RL)...
Abstract Schizophrenia (SCZ), a highly heritable mental disorder, is characterized by cognitive impairment, yet the extent of shared genetic basis between schizophrenia and performance (CP) remains poorly understood. Therefore, we aimed to explore polygenic overlap SCZ CP. Specifically, bivariate causal mixture model (MiXeR) was employed estimate ( n = 130,644) CP 257,841), conjunctional false discovery rate (conjFDR) approach used identify loci. Subsequently, functional annotation...
Abstract Current control of prosthetic hands is ineffective when grasping deformable, irregular, or heavy objects. In humans, achieved under spinal reflexive the musculotendon skeletal structure, which produces a hand stiffness commensurate with task. We hypothesize that mimicking reflex on may improve performance and safety interacting human. Here, we present design compliant controller for neuromorphic model human reflex. The includes 6 motoneuron pools containing 768 spiking neurons, 1...
Oral biofilms are mixed-species microbial communities, and their uncontrolled outgrowth can express as oral diseases. Antimicrobial peptides represent alternative classes of antimicrobials that exhibit selectivity for prokaryotes. We wanted to test the effect a synthetic decapeptide antimicrobial, KSL, on development formed by isolated human salivary bacteria. used differential interference contrast microscopy, coupled with dual-flow cell system, determine KSL biofilm development. reductions...
Abstract Introduction Proteinuria in burn patients is common, and may be associated with acute kidney injury (AKI) adverse outcomes. We evaluated the incidences, outcomes, characteristics determinants of proteinuria its influence on AKI outcomes patients. Methods This retrospective study was carried out a hospital's department. The population consisted injuries admitted during five-year period. Positive urine dipstick readings were defined as mild (± or 1+) heavy (≥ 2+) proteinuria,...
Previous studies have shown that abnormal metabolic reprogramming in CD4+ T cells could explain the occurrence of several autoimmune disorders, including Sjogren's syndrome (SS). However, therapeutic targets metabolism remain to be explored. Here, we report glutaminase 1 (Gls1), a pivotal factor glutaminolysis, might involved pathogenesis SS. The expression Gls1 was upregulated infiltrated labial and circulating SS patients. Inhibiting with BPTES significantly abolished proliferation rate,...
Restoring neuromuscular reflex properties in the control of a prosthetic hand may potentially approach human-level grasp functions hand. Previous studies have confirmed feasibility real-time emulation monosynaptic spinal loop for control. This study continues to explore how well biomimetic controller could enable amputee perform force-control tasks that required both strength and error-tolerance. The was programmed on neuromorphic chip reflex. model-calculated force finger flexor used drive...
A flexible endoscope introduces more dexterity to the image capturing in endoscopic surgery. However, manual control or automatic based on instrument tracking does not handle misorientation between video and surgeon. We propose an method that tracks surgeon's head with respect object surgical scene. The robotic is actuated so it captures scene from same perspective as surgeon wears a head-mounted display observe video. frustum of rendered augmented reality overlay provide guidance. developed...
White matter hyperintensities (WMHs) were commonly seen in brain magnetic resonance imaging (MRI) of the elderly. Many studies found that WMHs associated with cognitive decline and dementia. However, association between different regions remains debated.We explored severity 115 non-demented elderly (≥50 years old) sampled from Wuliqiao Community located urban area Shanghai. MRI scans done during 2009-2011 at beginning study. Severity was scored by Improved Scheltens Scale Cholinergic...
Objective: Human neuromuscular reflex control provides a biological model for compliant hand prosthesis. Here we present computational approach to understanding the emerging human-like compliance, force and position control, stiffness adaptation in prosthetic with replica of human reflex. Methods: A virtual twin was constructed MuJoCo environment tendon-driven anthropomorphic structure. Biorealistic mathematic models muscle, spindle, spiking-neurons monosynaptic were implemented neuromorphic...
Cerebral microbleeds (CMBs) are frequently found in the healthy elderly. However, data on prevalence and risk factors of CMBs general population China lacking.A cross-sectional study focusing was conducted stroke-free elderly from Shanghai Wuliqiao community. MRI performed at 3Tesla cardiovascular (eg, age, smoking history, hypertension), cerebral small vessel disease (CSVD) markers white matter hyperintensities, lacunar infarction, enlarged perivascular space) genetic information APOE, CR1)...
Background Autoimmune encephalitis (AE) is a noninfectious emergency with severe clinical attacks. It difficult for the earlier diagnosis of acute AE due to lack antibody detection resources. Purpose To construct deep learning (DL) algorithm using multi‐sequence magnetic resonance imaging (MRI) identification AE. Study Type Retrospective. Population One hundred and sixty patients (90 women; median age 36), 177 herpes simplex virus (HSVE) (89 39), 184 healthy controls (HC) (95 39) were...
The human hand has compliant properties arising from muscle biomechanics and neural reflexes, which are absent in conventional prosthetic hands. We recently proved the feasibility to restore neuromuscular reflex control (NRC) hands using real-time computing neuromorphic chips. Here we show that restored NRC augments ability of individuals with forearm amputation complete grasping tasks, including standard Box Blocks Test (BBT), Golf Balls (GBT), Potato Chips (PCT). latter two were more...
Penetrance estimates of the leucine-rich repeat kinase 2 (LRRK2) variants for Parkinson disease (PD) vary widely. G2385R is one most common LRRK2 in Asian populations, and its penetrance currently unknown. We aimed to estimate Chinese population.The variant was tested by Sanger sequencing 6386 participants older than 50 years, all from community cohort established Shanghai Ruijin Hospital 2009-2011. carriers matched noncarriers underwent a brief questionnaire survey (including sex, current...
Objective To develop a fusion model combining clinical variables, deep learning (DL), and radiomics features to predict the functional outcomes early in patients with adult anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis Southwest China. Methods From January 2012, two-center study of anti-NMDAR was initiated collect MRI data from acute Two experienced neurologists independently assessed patients’ prognosis at 24 moths based on modified Rankin Scale (mRS) (good outcome defined as mRS...
In this paper, a novel prototype of cable-driven prosthetic hand with biorealisitic muscle property was developed. A pair antagonistic muscles controlled the flexion and extension index finger. Biorealistic properties were emulated using neuromorphic model reflex in real time. The output coupled to servo motor that tracked computed force. able track within frequency range from 0 8.29 (Hz) phase shift 2 205 (deg). Surface electromyography signals collected amputee's forearm used as α commands...