A5100359635- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 diagnosis using AI
- Alzheimer's disease research and treatments
- Drug-Induced Hepatotoxicity and Protection
- Bioinformatics and Genomic Networks
- COVID-19 epidemiological studies
- Ginkgo biloba and Cashew Applications
- Autoimmune Neurological Disorders and Treatments
- Liver Disease and Transplantation
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal Diseases and Glomerulopathies
- Acute Ischemic Stroke Management
- Parkinson's Disease and Spinal Disorders
- Clinical Laboratory Practices and Quality Control
- Machine Learning in Healthcare
- Chronic Kidney Disease and Diabetes
Shenzhen Third People’s Hospital
2020-2025
Chongqing Three Gorges University
2025
Chongqing University
2025
Chongqing Three Gorges Central Hospital
2025
Shanghai Jiao Tong University
2015-2024
Central South University
2020-2024
Xiangya Hospital Central South University
2020-2024
Jiangyin People's Hospital
2024
Zhejiang University
2010-2023
Sir Run Run Shaw Hospital
2023
α-Synuclein misfolding and aggregation play an important role in the pathogenesis of Parkinson's disease (PD). Loss function mutation PARK7/DJ-1 gene cause early-onset familial PD. DJ-1 can inhibit α-synuclein aggregation, may at early step process. Soluble wild-type is mainly degraded by chaperone-mediated autophagy (CMA), impairment CMA closely related to Here, we investigated whether could reduce accumulation CMA. knockout mice siRNA knockdown SH-SY5Y cells were used investigate potential...
To determine the predictive value of clinical assessment and dopamine transporter (DAT) uptake for early development neurodegenerative synucleinopathy diseases from idiopathic REM sleep behavior disorder (iRBD) over 5 years in a Chinese population.Forty-three patients with iRBD were administered tests, 35 examined by DAT-SPECT imaging during 2011. Cox proportional hazard Kaplan-Meier analyses used to evaluate markers follow-up study years.Eighteen (41.9%) developed after median 4.1...
Imaging markers sensitive to neurodegeneration in the substantia nigra are critically needed for future disease-modifying trials. Previous studies have demonstrated utility of posterior free water as a marker progression Parkinson's disease. In this study, we tested hypothesis that is elevated idiopathic REM sleep behaviour disorder, which considered prodromal stage synucleinopathy. We applied free-water imaging 32 healthy control subjects, 34 patients with disorder and 38 Eighteen subjects...
Currently, there are no definitive therapies for coronavirus disease 2019 (COVID-19). Gut microbial dysbiosis has been proved to be associated with COVID-19 severity and probiotics is an adjunctive therapy COIVD-19. However, the potential benefit of in not studied. We aimed assess relationship use clinical outcomes patients COVID-19.We conducted a propensity-score matched retrospective cohort study adult COVID-19. Eligible received either plus standard care (probiotics group) or alone...
Objective The longitudinal effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the liver are unknown. This study aimed to characterize dynamic changes in function test abnormalities patients with COVID-19 at phase and recovery phase. Methods A prospective cohort involved who were admitted Shenzhen Third People’s Hospital between January 11, 2020, April 27, 2020. Patients underwent tests hospitalization outpatient visit 1-month, 3-month, 6-month, 12-month...
The long-term clinical status of coronavirus disease 2019 (COVID-19) in recovered patients remains largely unknown. This prospective cohort study evaluated COVID-19 and explored the associated risk factors. At outpatient visit, underwent routine blood tests, physical examinations, pulmonary function 6-min walk test, high-resolution computed tomography (CT) chest, extrapulmonary organ tests. 230 were analyzed. Half (52.7%) reported at least one symptom, most commonly fatigue (20.3%) sleep...
This study intends to investigate the connection between non-contrast computed tomography (NCCT) imaging findings and neurological function scores in patients with intracerebral hemorrhage (ICH) a long follow up of 451 patients. Between January 2020 October 2021, retrospective review was undertaken on ICH. The NCCT results within 24 h symptom onset, clinical information, biochemical markers one-year outcome post-discharge were collected analyzed. Subsequently, prognostic model devised...
Both high prevalence and incidence rates of delirium occur frequently among patients aged 65 years or older in intensive care units (ICUs) are accompanied by adverse outcomes. Because lack nursing staff resources imperfect humanistic care, is easily overlooked both physicians nurses the ICU Mainland China.This study aimed to explore rate determine risk factors critically ill patients.A prospective observational was conducted on who were admitted consecutively two ICUs a university-affiliated...
A link between the gut microbiome and Parkinson's disease (PD) has been intensively studied, more than 100 differential genera were identified across studies. However, predominant contributing to PD remain poorly understood. Inspired by recent advances showing microbiota distribution in blood brain, we, here, comprehensively investigated currently available fecal data (1,914 samples) identify significantly altered genera, which further validated comparison results from analysis of (85 brain...
Summary Background Over 90 genetic variants have been found to be associated with Parkinson’s disease (PD) in genome-wide association studies, however, the neural mechanisms of previously identified risk PD were largely unexplored. The objective this study was evaluate associations between PD-associated and brain gene expressions, clinical features, networks. Methods patients (n = 198) receiving magnetic resonance imaging examinations from Progression Markers Initiative (PPMI) database...
The systematic mechanisms of acute intracerebral hemorrhage are still unknown and unverified, although many recent researches have indicated the secondary insults. This study was aimed to disclose pathological mechanism identify novel biomarker therapeutic target candidates by plasma proteome. Patients with AICH (n = 8) who demographically matched healthy controls 4) were prospectively enrolled, their samples obtained. TMT-LC–MS/MS-based proteomics approach used quantify differential...
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of synucleinopathies. Patients with synucleinopathies frequently display abnormalities. However, whether patients iRBD have abnormalities remains unknown.The aim this study was to assess and related gray matter alterations explore such can serve as biomarkers indicate phenoconversion in iRBD.Forty early disease progression 35 healthy control subjects participated 15-minute ocular-tracking task that evaluated...
The proteinaceous aggregates rich in copper, zinc superoxide dismutase (SOD1) have been shown to be involved pathogenesis of amyotrophic lateral sclerosis (ALS). Since negatively charged species such as nucleic acids frequently found associated with the deposits tissues patients amyloid diseases, we examined here aggregation behavior SOD1 presence DNA under acidic conditions that facilitate protein aggregation. Several forms double-stranded were tested trigger by light scattering, single-...
The relationship between major depressive disorder (MDD) and dysthymia, a form of chronic depression, is complex. two conditions are highly comorbid it unclear whether they separate disease entities. We investigated the extent to which patients with dysthymia superimposed on depression can be distinguished from those recurrent MDD.We examined clinical features in 1970 Han Chinese women MDD (DSM-IV) 30 60 years age across China. Logistic regression was used determine association disorders...
The tremendous development of laparoscopic hepatectomy helps to relieve the difficulties encountered during open hepatectomy. Therefore, a difficulty scoring system was produced assess grade aim this study explore whether IWATE-DSS is comparable long-term outcomes LH for hepatocellular carcinoma. Clinical data from all consecutive patients who underwent carcinoma at Sir Run Shaw Hospital, Hangzhou, were prospectively collected and reviewed. level operations graded using IWATE-DSS....
Introduction:The purpose of this study was to compare the viral shedding time in patients infected with Omicron variant during Paxlovid therapy and conventional analyze effects on COVID-19.Methods: In study, demographic clinical characteristics laboratory data 3159 SARS-CoV -2 treated at Jilin Province People's Hospital were collected analyzed.A total 362 received therapy, 2797 therapy.After propensity score matching (PSM), 1086 obtained. Results:The difference platelet (PLT) count between...
Penetrance estimates of the leucine-rich repeat kinase 2 (LRRK2) variants for Parkinson disease (PD) vary widely. G2385R is one most common LRRK2 in Asian populations, and its penetrance currently unknown. We aimed to estimate Chinese population.The variant was tested by Sanger sequencing 6386 participants older than 50 years, all from community cohort established Shanghai Ruijin Hospital 2009-2011. carriers matched noncarriers underwent a brief questionnaire survey (including sex, current...
Sepsis associated encephalopathy (SAE) is a common neurological complication of sepsis. Delirium symtom SAE. The pathophysiology SAE still unclear, but several likely mechanisms have been proposed, such as mitochondrial and endothelial dysfunction, neurotransmission disturbances, derangements calcium homeostasis, cerebral microcirculation brain hypoperfusion. Near-infrared spectroscopy (NIRS) non-invasive measure for regional oxygen saturation (rSO