A5031453187- Birth, Development, and Health
- Air Quality and Health Impacts
- Telomeres, Telomerase, and Senescence
- Heavy Metal Exposure and Toxicity
- Climate Change and Health Impacts
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health, Environment, Cognitive Aging
- Spine and Intervertebral Disc Pathology
- Gestational Diabetes Research and Management
- Plant Reproductive Biology
- Spinal Fractures and Fixation Techniques
- Aluminum toxicity and tolerance in plants and animals
- Medical Imaging and Analysis
- Plant Molecular Biology Research
- Pregnancy and preeclampsia studies
- Diabetes Management and Research
- Health disparities and outcomes
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- 2D Materials and Applications
- Photosynthetic Processes and Mechanisms
- Geochemistry and Elemental Analysis
- Selenium in Biological Systems
- Transplantation: Methods and Outcomes
Trinity College Dublin
2024-2025
First Affiliated Hospital of Guangzhou Medical University
2023-2025
State Key Laboratory of Respiratory Disease
2023-2025
Guangzhou Medical University
2023-2025
Advanced Materials and BioEngineering Research
2024
Anhui Polytechnic University
2020-2024
Shanghai Zhangjiang Laboratory
2023-2024
Huazhong Agricultural University
2021-2024
Huazhong University of Science and Technology
2018-2023
Kunming University of Science and Technology
2021-2023
The effect of long-term exposure to air pollution on the development chronic obstructive pulmonary disease (COPD) is still controversial, and role interactions with genetic risk lifestyle in COPD unclear.We included 452762 participants derived from UK Biobank. Annual concentrations pollutions, including particle matter (PM2.5, PM10), nitrogen oxides (NOx), dioxide (NO2), were assessed using land-use regression model. We applied Cox proportional hazard model evaluate associations between...
Despite significant developments in optical imaging of superoxide anion (O2•–) as the preliminary reactive oxygen species, novel visualizing strategies that offer ultrahigh sensitivity are still imperative. This is mainly because intrinsic concentrations O2•– extremely low living systems. Herein, we present rational design and construction a new polymer nanoprobe PCLA-O2•– for detecting based on chemiluminescence (CL) resonance energy transfer without an external excitation source....
Prenatal exposure to thallium is related adverse birth outcomes. However, little known about the effects of prenatal on mitochondrial DNA copy number (mtDNAcn) in newborns; such knowledge might reveal a potential mechanism linking maternal and To investigate trimester-specific associations with cord blood leukocyte mtDNAcn. A total 746 pregnant women urinary samples were recruited from Wuhan Children Hospital between November 2013 March 2015 City, China. The concentration urine was...
Evidence linking air pollution to major depressive disorder (MDD) remains sparse and results are heterogeneous. In addition, the evidence about interaction joint associations of genetic risk lifestyle with on incident MDD unclear. We aimed examine association various pollutants assessed whether susceptibility influence associations.This population-based prospective cohort study analyzed data collected between March 2006 October 2010 from 354,897 participants aged 37 73 years UK Biobank....
Telomere length (TL) is considered as a surrogate of biological aging and has been related to aging-related diseases. The initial setting newborn TL important implications for telomere dynamics in adulthood, affected by the intrauterine environment. However, effects prenatal air pollution exposure on are poor understood. We aimed explore trimester-specific relationships between maternal TL. Between November 2013 March 2015, total 762 mother-newborn pairs were recruited birth cohort study...
Prior studies have suggested exposure to heavy metals and endocrine disrupting chemicals could disturb the homeostasis of thyroid stimulating hormone (TSH), but no epidemiology study concerning influence rare earth elements (REE) during pregnancy on neonatal TSH levels. The present aimed investigate relationships between prenatal REE A total 7367 pregnant women were recruited from Wuhan Children’s Hospital September 2012 October 2014 in Wuhan, China. Urinary concentrations cerium (Ce),...
Newborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to investigate whether there an association between prenatal cadmium exposure relative cord blood Chinese newborns. Participants were 410 mother–newborn pairs drawn from prospective birth cohort conducted Wuhan, China, November 2013 March 2015. Urine samples collected pregnant women during...
Metabolic syndrome severity, expressed by the continuous metabolic risk score (MetS score), has been demonstrated to be able predict future health conditions. However, little is known about association between MetS and renal function.A total of 22,719 participants with normal function abstracted from Kailuan Study were followed 2006 2016. The new onset chronic kidney disease (CKD) was defined as eGFR <60 ml/min per 1.73 m2 and/or proteinuria >300 mg/dl. Progressive decline in an annual...
SARS-CoV-2 infection and the resultant COVID-19 pneumonia cause significant damage to airway lung epithelium. This manifests as mucus hypersecretion, pulmonary inflammation fibrosis, which often lead long-term complications collectively referred long COVID or post-acute sequelae of (PASC). The epithelium, first line defence against respiratory pathogens, depends on basal stem cells (BSCs) for regeneration. Alterations in BSCs are associated with impaired epithelial repair may contribute...
Two-dimensional (2D) transition metal dichalcogenides (TMDCs), exemplified by molybdenum disulfide (MoS2), have shown exceptional potential for data-centred, energy-efficient electronic applications due to their unique electrical, optoelectronic, and mechanical properties. However, challenges such as the controllable synthesis of high-quality, large-area 2D MoS2 films mitigation contamination during growth remain significant barriers integration into advanced technologies. Here, we developed...
Octave-spanning soliton frequency combs generated by microresonators present a compact and low-noise tool for high-resolution time distance measurements through self-referencing. While these have been observed on various photonic platforms, their practical deployment is often hindered complex control mechanisms, resulting in low yield of useful devices. To address challenges, we optimized dual-mode scheme incorporating heaters directly onto <a:math...
Cytosolic malate dehydrogenase (MDH) is a key enzyme that regulates the interconversion between and oxaloacetate (OAA). However, its role in modulating storage compound accumulation maize endosperm largely unknown. Here, we characterized novel naturally occurring mdh4-1 mutant, which produces small, opaque kernels exhibits reduced starch but enhanced lysine content. Map-based cloning, functional complementation allelism analyses identified ZmMdh4 as causal gene. Enzymatic assays demonstrated...
Background Cardiovascular health (CVH) status is associated with cardiovascular diseases (CVD). However, evidence for association of CVH change risk CVD scarce. Methods and Results Seven metrics (smoking status, body mass index, physical activity, diet, total cholesterol, blood pressure, fasting glucose) were used to evaluate the status. Having 0 2, 3 4, 5 7 ideal categorized as low, moderate, high respectively. Change in was assessed from 2006/2007 2010/2011. We calculated lifetime using a...
Background: Telomere length (TL) is a marker of biological aging and inversely related to aging-related diseases. The setting TL at birth may have important implications for lifelong telomere dynamics; however, its determinants remain poorly understood. Objectives: purpose our study was explore the relationships between prenatal exposure phthalates umbilical cord blood TL. Methods: A total 762 mother–newborn pairs were recruited from cohort performed November 2013 March 2015 in Wuhan, China....
LINC00426 is a newly identified long non-coding RNA (lncRNA) with unacknowledged biological roles. Here we set out to characterize the expression status of in osteosarcoma and understand its mechanistic involvement incidence doxorubicin (Dox) resistance.The relative miR-4319 was determined by real-time PCR. Cell viability proliferation response silencing or over-expression measured CCK-8 kit colony formation assay, respectively. The direct association between analyzed pulldown assay...
Abstract Background Two types of screw trajectories are commonly used in lumbar surgery. Both traditional trajectory (TT) and cortical bone (CBT) were shown to provide equivalent pull-out strengths a screw. CBT utilizing laterally-directed engaging only the pedicle is widely minimal invasive spine posterior fusion It has been demonstrated that exerts lower likelihood violating facet joint, superior strength than TT screws, especially osteoporotic vertebral body. No design yet apply this...