A5051316009- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Anesthesia and Pain Management
- Congenital Heart Disease Studies
- Non-Invasive Vital Sign Monitoring
- Neonatal Health and Biochemistry
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Anesthesia and Sedative Agents
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Anomalies and Treatments
- Airway Management and Intubation Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sepsis Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- S100 Proteins and Annexins
- Metabolism and Genetic Disorders
Gaozhou People's Hospital
2024
First Affiliated Hospital of Chengdu Medical College
2023
Guangdong Provincial People's Hospital
2022
Guangdong Academy of Medical Sciences
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2021
Xiangya Hospital Central South University
2018-2021
Central South University
2018-2021
National Clinical Research
2021
Hunan Provincial Center for Disease Control and Prevention
2021
Southwest University
2020
<b>Background:</b> Surgical closure of patent ductus arteriosus (PDA) with severe pulmonary arterial hypertension in adults carries higher risk than children. <b>Objectives:</b> To investigate the application self-expandable occluders for transcatheter PDA associated adults, and assessment immediate short-term results. <b>Methods:</b> 29 adult patients (6 men, 23 women) underwent attempted at a mean (standard deviation (SD)) age 31.1 (11.4) years (range 18–58 years) (SD) weight 54.1 (7.1) kg...
Section:ChooseTop of pageAbstract <<MethodologyStatistics and Data Analy...ResultsDiscussionReferencesCITING ARTICLES
<b><i>Background:</i></b> Noninvasive ventilation is increasingly used in very-low-birth-weight infants (VLBWI) to reduce complications that occur with invasive ventilation. However, the physiological effects of synchronization during noninvasive nasal intermittent mandatory (IMV) have not been tested VLBWI immediately after extubation. <b><i>Objective:</i></b> We aimed study short-term synchronized IMV (S-NIMV) compared nonsynchronized (NIMV)...
Pulmonary arterial hypertension (PAH) is a severe complication of hereditary hemorrhagic telangiectasia (HHT); however, little known about its clinical characteristics and prognosis. Nine newly diagnosed HHT-PAH patients were prospectively recruited between October 2007 January 2016 followed up every half-year. Eighteen idiopathic pulmonary (IPAH) patients, matched with on mean pressure, capillary wedge vascular resistance, cardiac index, World Health Organization (WHO) functional class...
<b><i>Background:</i></b> There are no clear evidence-based recommendations on the use of different techniques respiratory support and chest compressions (CC) during neonatal cardiopulmonary resuscitation (CPR). <b><i>Objectives:</i></b> To determine effects strategies along with CC representing clinical practice return spontaneous circulation (ROSC) in hypoxic newborn piglets cardiac arrest. We hypothesized that a T-piece resuscitator (TPR)...
<b><i>Background:</i></b> There are no evidence-based recommendations on the use of different techniques respiratory support and chest compressions (CC) during neonatal cardiopulmonary resuscitation (CPR). <b><i>Objectives:</i></b> We studied short-term effects ventilatory strategies along with CC representing clinical practice gas exchange [arterial oxygen saturation (SaO<sub>2</sub>), arterial partial pressure...
Pulse oximetry is widely used in intensive care and emergency conditions to monitor arterial oxygenation guide oxygen therapy.To study the reliability of pulse comparison with CO-oximetry newborn piglets during cardiopulmonary resuscitation (CPR).In a prospective cohort 30 healthy piglets, cardiac arrest was induced, thereafter each piglet received CPR for 20 min. Arterial saturation monitored continuously by (SpO2). blood analyzed functional (SaO2) every 2 SpO2 compared coinciding SaO2...
Idiopathic pulmonary arterial hypertension is a progressive disease with high mortality an increasing burden of right ventricular. Right ventricular dyssynchrony was observed in idiopathic hypertension, but the association unclear. This study aimed to investigate impact on survival hypertension. A total 116 patients were enrolled this study. All these underwent comprehensive clinical evaluation. assessed by two-dimensional speckle-tracking echocardiography. The time peak strain (Tpeak)...
Abstract Myositis-specific autoantibodies are important diagnostic and prognostic markers. The aim of our study is to detect anti-3-hydroxy 3-methylutaryl coenzyme A reductase (anti-HMGCR) antibody using novel unlabeled immunoprecipitation (IP) assay immunoblotting in Chinese patients with myositis clarify the features anti-HMGCR-positive patients. In present study, we established IP HMGCR C-terminus for anti-HMGCR detection. presence was screened 181 myositis. sera from 12 were positive...
<b><i>Background:</i></b> Pulse oximetry is widely used in intensive care and emergency conditions to monitor arterial oxygenation guide oxygen therapy. <b><i>Objective:</i></b> To study the reliability of pulse comparison with CO-oximetry newborn piglets during progressive hypoxia, cardiac arrest, cardiopulmonary resuscitation (CPR), after return spontaneous circulation (ROSC). <b><i>Methods:</i></b> Thirty-three were...
Abstract Background: Coronary artery disease (CAD) is the commonest cause of heart failure (HF), whereas pulmonary hypertension (PH) has not been established or reported in this patient population. Therefore, we assessed prevalence, risk factors, and survival CAD-associated HF (CAD-HF) complicated with PH. Methods: Symptomatic CAD-HF patients were continuously enrolled prospective, multicenter registry study. Echocardiography, coronary arteriography, left right catheterization (RHC), other...
Sepsis associated encephalopathy (SAE) is a common neurological complication of sepsis. Delirium symtom SAE. The pathophysiology SAE still unclear, but several likely mechanisms have been proposed, such as mitochondrial and endothelial dysfunction, neurotransmission disturbances, derangements calcium homeostasis, cerebral microcirculation brain hypoperfusion. Near-infrared spectroscopy (NIRS) non-invasive measure for regional oxygen saturation (rSO
There are few data available on the interaction of inflations, chest compressions (CC), and delivery tidal volumes in newborn infants undergoing resuscitation presence endotracheal tube (ET) leaks.To determine effects different respiratory support strategies along with CC changes volume ET leaks hypoxic piglets cardiac arrest.Asphyxiated piglets, intubated weight-adapted uncuffed ET, were randomized into three groups resuscitated according to ILCOR 2010 guidelines: (1) T-piece resuscitator...
Right ventricular (RV) intraventricular mechanical dyssynchrony detected by two-dimensional speckle tracking echocardiography (2D-STE) has been reported to be correlated with a decrease in RV contractile efficiency pulmonary hypertension (PH) patients, while little attention paid biventricular dysfunction. Therefore, we aimed evaluate the predictive value of 2D-STE interventricular for exercise capacity and disease severity patients pre-capillary PH (PcPH).Conventional transthoracic...
We investigated and compared the correlations between two‐dimensional speckle tracking echocardiography detected left ventricular peak early diastolic strain rates (global: global rate; septum: rate of septum; free wall: wall) disease severity in pre‐capillary pulmonary hypertension. Seventy‐four hypertension patients (23 males 51 females, 35 ± 13 years) thirty healthy controls were consecutively recruited for analyses our study. Medical records reviewed to capture clinical data; risk...
Both portal hypertension and splenectomy are risk factors for pulmonary hypertension. However, the interactions between in development of remain unclear. Twelve newly diagnosed patients with a previous history induced by were recruited November 2008 May 2017. We compared their clinical features, hemodynamics, prognosis idiopathic arterial patients, who matched cardiac index, mean pressure, vascular resistance. also characteristics hypertension-post-splenectomy-pulmonary eight portopulmonary...
Dysfunction of the sympathetic nervous system and increased epicardial adipose tissue (EAT) have been independently associated with occurrence cardiac arrhythmia. However, their exact roles in triggering arrhythmia remain elusive. Here, using an vitro coculture neurons, cardiomyocytes, adipocytes, we show that adipocyte-derived leptin activates neurons increases release neuropeptide Y (NPY), which turn triggers cardiomyocytes by interacting Y1 receptor (Y1R) subsequently enhancing activity...
Purpose/Aim Bronchopulmonary dysplasia (BPD) is associated with poor survival in preterm infants. Intrauterine infection can aggravate the degree of obstruction alveolar development premature infants; however, pathogenic mechanism remains unclear. In this study, we sought to determine whether pyroptosis could be inhibited by downregulating mammalian target rapamycin (mTOR) activation and inducing autophagy BPD-affected lung tissue.
<h3>Background</h3> Impaired hemodynamics in neonatal sepsis increase the mortality. <h3>Objective</h3> Studying changes and peripheral perfusion premature infants with suspected comparing them stable matched controls. <h3>Methods</h3> Left (LVO) right ventricular output (RVO), superior vena cava (SVC) flow were measured using echocardiography newborn after DOL 7. Measurements repeated 3 times q 24 h when antibiotics discontinued. Anterior cerebral artery RI oxygenation of brain kidney by...
Objective: To investigate the clinical significance of transcranial Doppler (TCD) in early diagnosis sepsis-associated encephalopathy(SAE). Methods: Septic patients admitted to intensive care unit(ICU) were recruited at Xiangya Hospital, Central South University from July 2015 March 2016. Clinical data and TCD parameters during 24 hours after admission collected. All screened for delirium using confusion assessment method unit (CAM-ICU) twice a day. The gold standard SAE was positive CAM-ICU...
<b>Background:</b> Iron deficiency in the absence of anaemia is common patients with idiopathic pulmonary arterial hypertension (IPAH). It has been associated inappropriately raised levels hepcidin, key regulator iron homeostasis and correlates disease severity worse clinical outcomes. Oral absorption may be impeded by elevated hepcidin levels. The safety benefits parenteral replacement IPAH are unknown. <b>Methods:</b> Iron-deficient (defined as ferritin <37µg/L, serum <10.3µmol/L,...