A5089843507- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Heart Failure Treatment and Management
- Vascular Anomalies and Treatments
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Valve Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- Pituitary Gland Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Renin-Angiotensin System Studies
- Cardiac Structural Anomalies and Repair
- Vasculitis and related conditions
- Blood Pressure and Hypertension Studies
- Myasthenia Gravis and Thymoma
- Transplantation: Methods and Outcomes
- Ultrasound in Clinical Applications
- Lung Cancer Research Studies
- Cardiovascular Conditions and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Heart rate and cardiovascular health
- Vascular Tumors and Angiosarcomas
Peking Union Medical College Hospital
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Fu Wai Hospital
2024
University of Pittsburgh
2012
Qilu Hospital of Shandong University
2010-2011
Ministry of Education of the People's Republic of China
2011
State Key Laboratory of Respiratory Disease
2007
Guangzhou Medical University
2007
The intensity of hemolytic anemia has been proposed as an independent risk factor for the development certain clinical complications sickle cell disease, such pulmonary hypertension, hypoxemia and cutaneous leg ulceration. A composite variable derived from several individual markers hemolysis could facilitate studies underlying mechanisms hemolysis. In this study, we assessed association with outcomes in anemia. component was calculated by principal analysis reticulocyte count, serum lactate...
Introduction: Mounting evidence indicates a possible connection between the systemic inflammatory response index (SIRI) and prognosis of heart failure, but its role in idiopathic pulmonary arterial hypertension (IPAH) is not well understood. This study aimed to investigate relationship SIRI variables such as functional ability, echocardiography results, hemodynamic measurements, long-term outcomes patients with IPAH. Methods: The included 426 consecutive IPAH who underwent right...
Abstract Background Insulin resistance (IR) plays an important role in the pathophysiology of cardiovascular disease. Recent studies have shown that diabetes mellitus and impaired lipid metabolism are associated with severity prognosis idiopathic pulmonary arterial hypertension (IPAH). However, relationship between IR is poorly understood. This study explored association four indices IPAH using data from a multicenter cohort. Methods A total 602 consecutive participants were included this...
Balloon pulmonary angioplasty (BPA) has been demonstrated to improve cardiac function and exercise capacity in patients with inoperable chronic thromboembolic hypertension (CTEPH), but its instant impact on cardiopulmonary seldom evaluated. This study aims determine the safety efficacy of BPA immediate lasting effects among CTEPH patients. From May 2018 January 2019, who underwent sessions were consecutively enrolled. Hemodynamics measured by right heart catheterization, selective...
We aimed to examine the hypothesis that circulating trimethylamine-N-oxide (TMAO) levels serve as a biomarker in pulmonary arterial hypertension (PAH), and determine whether 3,3-dimethyl-1-butanol (DMB), TMAO inhibitor, exerted protective effect monocrotaline (MCT)-induced PAH rats.In-patients with were prospectively recruited from Fuwai Hospital. Fasting blood samples obtained assess other laboratory values during initial second hospitalization. In MCT-induced rat, normal diet water...
Abstract Background Trimethylamine N-oxide (TMAO), the gut microbiota-dependent metabolite, is a potential biomarker in several cardiovascular diseases. However, no study has investigated its value pulmonary hypertension (PH). Therefore, this aimed to explore association between plasma TMAO levels and prognosis patients with PH. Methods Inpatients idiopathic/heritable arterial (IPAH/HPAH), PAH associated congenital heart disease (CHD-PAH), chronic thromboembolic (CTEPH) at Fuwai Hospital...
Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder associated with high pulmonary artery pressure. Genetic testing enables early diagnosis offers an opportunity for family screening. To identify genetic mutations help make precise diagnosis, we performed in 191 probands PAH tried to analyze the genotype-phenotype correlation. Initially, samples (n = 119) were submitted BMPR2 screening using Sanger sequencing. Later, developed panel test causal 13 genes related call...
Background: Gut microbiota assumes an essential role in the development and progression of pulmonary arterial hypertension (PAH). Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite, is correlated with prognosis patients PAH. However, correlation between changes TMAO (ΔTMAO) PAH remains elusive. Objectives: To investigate association ΔTMAO PAH, explore whether dynamic assessment level was superior to measurement at single time point predicting prognosis. Design:...
Malnutrition is common in patients with chronic cardiovascular disease and associated significantly higher all-cause mortality. Approximately one-third of heart failure are malnourished. However, the relationship between malnutrition idiopathic pulmonary arterial hypertension (IPAH) remains unclear. This study aimed to clarify prognostic value IPAH. A total 432 consecutive participants IPAH were included this March 2013 August 2021. Three assessment tools, including geriatric nutritional...
Background and Objective The association between plasma betaine levels cardiovascular diseases (CVDs) has been revealed except for pulmonary hypertension (PH). In this study, we aimed to explore the role of in patients with PH. Methods Inpatients PH at Fuwai Hospital were enrolled after excluding relative comorbidities. Each patient received least one follow-up through a clinical visit, fasting blood was obtained both first second hospitalization detection. primary endpoint defined as...
Abstract Background Variants in the gene encoding bone morphogenetic protein receptor type II ( BMPR2 ) are most common genetic cause of pulmonary arterial hypertension (PAH), whereas biallelic variants eukaryotic translation initiation factor 2 alpha kinase 4 EIF2AK4 described veno-occlusive disease/pulmonary capillary haemangiomatosis (PVOD/PCH). Racial background may influence clinical characteristics patients diagnosed with PAH or PVOD/PCH. Here, we compared and survival between a...
Abstract Backgrounds Mounting evidences have highlighted the association between metabolites and cardiovascular diseases. Our previous works demonstrated that circulating metabolite, trimethylamine oxide, was associated with prognosis of patients pulmonary hypertension (PH). Choline is a precursor oxide its role in PH remains unknown. Here, we aimed to validate hypothesis choline levels were prognoses PH. Methods Inpatients diagnosed PH—defined as mean arterial pressure ≥ 25 mmHg by right...
Background: The hemodynamic results of balloon pulmonary angioplasty vary among patients with inoperable chronic thromboembolic hypertension (CTEPH). Previous studies revealed that microvasculopathy accounted for residual after endarterectomy, which could be reflected by the diffusing capacity carbon monoxide (DLCO). We aimed to identify whether DLCO predict BPA response. Materials and Methods: retrospectively analyzed 75 consecutive CTEPH who underwent from May 2018 January 2021 at Fuwai...
The COMPERA 2.0 4-stratum (4-S) risk score has been demonstrated superior over the 3-stratum (3-S) one in patients with pulmonary arterial hypertension and medically managed chronic thromboembolic (CTEPH). We aimed to determine prognostic value of original 4-S 3-S two new derivative versions CTEPH who underwent balloon angioplasty (BPA).We retrospectively enrolled 175 BPA-treated CTEPH. assessed stratification before after each BPA session by (by rounding decimal nearest integer) proposed...
Pulmonary artery (PA) dilatation is commonly observed in patients with pulmonary hypertension (PH). However, the clinical aspects of PA various etiology PH remain unknown. In this study, we investigated and imaging characteristics 1018 different subtypes arterial (PAH) chronic thromboembolic (CTEPH). The independent determinants for all-cause death were identified using univariate multivariate Cox proportional hazard models. was 88.8% patients, 27.2% had a diameter/ascending aorta diameter...
Background: Natriuretic peptide (NP) is high in atrial fibrillation (AF) and may decrease after cardioversion to sinus rhythm the levels of NP (ANP) brain (BNP) different types AF whether ANP BNP have predictive values for relapsed not been determined. Purpose: We aimed examine determine their roles AF, including a value AF. Methods Results: were measured 100 consecutive patients with without heart dysfunction at baseline 20 controls. All had higher than controls (p<0.01). After treatment...
Dysfunction of autonomic nervous system plays an important role in the development pulmonary hypertension. The present study aimed to investigate interaction between balloon angioplasty (BPA) and cardiac function by using heart-rate recovery at 1 min (HRR1) after exercise as a surrogate marker.We retrospectively enrolled 89 consecutive patients with inoperable chronic thromboembolic hypertension who underwent BPA from May, 2018 Jan, 2021. According hemodynamics follow-up, were categorized...
Right ventricular (RV) intraventricular mechanical dyssynchrony detected by two-dimensional speckle tracking echocardiography (2D-STE) has been reported to be correlated with a decrease in RV contractile efficiency pulmonary hypertension (PH) patients, while little attention paid biventricular dysfunction. Therefore, we aimed evaluate the predictive value of 2D-STE interventricular for exercise capacity and disease severity patients pre-capillary PH (PcPH).Conventional transthoracic...