A5027765146- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Viral Infections and Immunology Research
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Renal Transplantation Outcomes and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Frailty in Older Adults
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Diabetes Treatment and Management
- Mechanical Circulatory Support Devices
- Pharmaceutical Practices and Patient Outcomes
- Liver Disease Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Liver Disease and Transplantation
- Potassium and Related Disorders
- Pulmonary Hypertension Research and Treatments
- Blood Pressure and Hypertension Studies
- Obstructive Sleep Apnea Research
- Anesthesia and Neurotoxicity Research
- Cardiac Health and Mental Health
University of Michigan
2015-2024
Michigan Medicine
2015-2024
Cornell University
2019-2023
Weill Cornell Medicine
2019-2023
VA Center for Clinical Management Research
2021-2022
Johns Hopkins University
2010-2012
Johns Hopkins Medicine
2010
Marienkrankenhaus Kassel
2005
Abstract Insulin resistance and altered energy metabolism is common in non-alcoholic fatty liver disease (NAFLD) appears to also be associated with myocardial dysfunction. We aimed evaluate prevalence, staging clinical features correlated NAFLD among patients heart failure preserved ejection fraction (HFpEF). Adults HFpEF were prospectively enrolled. Demographic data collected. was defined based on biopsy, abdominal imaging or ICD-coding the absence of other diseases. Descriptive, bivariate...
Background: We evaluated the diagnostic and prognostic value of quantification myocardial flow reserve (MFR) with positron emission tomography (PET) in orthotopic heart transplant patients. Methods Results: retrospectively identified patients who underwent rubidium-82 cardiac PET imaging. The primary outcome was composite cardiovascular death, acute coronary syndrome, revascularization, failure hospitalization. Cox regression used to evaluate association MFR outcome. relationship allograft...
Abstract Background Malnutrition may be an important geriatric condition in adults with heart failure preserved ejection fraction (HFpEF), but studies on its prevalence and associated clinical outcomes are limited. The aim of this study was to determine if malnutrition is short‐term morbidity mortality ambulatory patients HFpEF. Methods We examined 231 a diagnosis HFpEF seen at two dedicated academic programs (Weill Cornell Medicine Michigan Medicine) from June 2018 April 2022. defined by...
Cardiac sialylation is involved in a variety of physiological processes the heart. Altered has been implicated heart failure (HF) mice. However, its role patients with HF unclear, and potential effect modulation cardiac worth exploring. We first assessed association between plasma N-acetylneuraminic acid levels incidence adverse cardiovascular events over median follow-up period 2 years. Next, immunoblot analysis lectin histochemistry were performed tissue to determine expression...
We aimed to examine the hypothesis that circulating trimethylamine-N-oxide (TMAO) levels serve as a biomarker in pulmonary arterial hypertension (PAH), and determine whether 3,3-dimethyl-1-butanol (DMB), TMAO inhibitor, exerted protective effect monocrotaline (MCT)-induced PAH rats.In-patients with were prospectively recruited from Fuwai Hospital. Fasting blood samples obtained assess other laboratory values during initial second hospitalization. In MCT-induced rat, normal diet water...
Patients who survive critical illness endure complex physical and mental health conditions, referred to as post-intensive care syndrome (PICS). The University of Michigan's cardiac outpatient long-term outreach (PICCOLO) clinic is designed for patients recently admitted the coronary unit (CCU). goal this understand post-CCU patients' needs design targeted interventions reduce their morbidity mortality post-discharge. As a first step toward goal, we aimed define post-discharge CCU survivors....
SUMMARY Identifying individuals at high risk of heart failure during precursor stages could allow for earlier initiation treatments to modify disease progression. We performed a GWAS meta- analysis generate (HF) polygenic score (PRS) then tested the association with phenotypic subtypes (reduced ejection fraction [HFrEF] and preserved [HFpEF]) evaluate value prediction. Results from European-ancestry showed that an ancestry-matched PRS, calculated GBMI meta-analysis outperformed previous HF...
Abstract Aims Statins improve survival and reduce rejection cardiac allograft vasculopathy after heart transplantation (HT). The impact of different statin intensities on clinical outcomes has never been assessed. We set out to determine the exposure cardiovascular HT. Methods results performed a retrospective study 346 adult patients who underwent HT from 2006 2018. Statin intensity was determined longitudinally based American College Cardiology/American Heart Association (ACC/AHA)...