A5004981617- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Ion channel regulation and function
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Molecular Biology Techniques and Applications
- ECG Monitoring and Analysis
- RNA modifications and cancer
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Metabolism, Diabetes, and Cancer
- Connective tissue disorders research
- Thermal Regulation in Medicine
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- Aortic aneurysm repair treatments
- Congenital heart defects research
- Aortic Disease and Treatment Approaches
- Ultrasound and Hyperthermia Applications
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Influenza Virus Research Studies
- Caveolin-1 and cellular processes
- Neonatal Respiratory Health Research
Huazhong University of Science and Technology
2012-2024
Tongji Hospital
2021-2024
Wenzhou Medical University
2024
Beijing Jingshida Electromechanical Equipment Research Institute
2024
Second Affiliated Hospital of Zhejiang University
2020-2023
Ministry of Education of the People's Republic of China
2023
Chongqing University
2021
Chongqing Three Gorges University
2021
Jiangmen Central Hospital
2006-2012
BackgroundAs aortic aneurysms (AAs) enlarge, they can become life-threatening if left undiagnosed or neglected. At present, there is a lack of radical treatments for preventing disease progression. Therefore, we aimed to identify effective drug targets that slow the progression AAs.MethodsA Mendelian randomization (MR) analysis was conducted therapeutic which are associated with AAs. Summary statistics AAs were obtained from two datasets: UK Biobank (2228 cases and 408,565 controls) FinnGen...
The progression of diabetic cardiomyopathy (DCM) is noticeably influenced by mitochondrial dysfunction. Variants caveolin 3 (CAV3) play important roles in cardiovascular diseases. However, the potential CAV3 function DCM and related mechanisms have not yet been elucidated.
Cardiac sialylation is involved in a variety of physiological processes the heart. Altered has been implicated heart failure (HF) mice. However, its role patients with HF unclear, and potential effect modulation cardiac worth exploring. We first assessed association between plasma N-acetylneuraminic acid levels incidence adverse cardiovascular events over median follow-up period 2 years. Next, immunoblot analysis lectin histochemistry were performed tissue to determine expression...
Diabetic cardiomyopathy (DCM), characterized by mitochondrial dysfunction and impaired energetics as contributing factors, significantly contributes to high mortality in patients with diabetes. Targeting key proteins involved might offer new therapeutic possibilities for DCM. Lentinan (LNT), a β-(1,3)-glucan polysaccharide obtained from lentinus edodes, has demonstrated biological activity modulating metabolic syndrome. In this study, the authors investigate LNT's pharmacological effects on...
Although the associations between serum lipid levels and aneurysms have been investigated in epidemiological studies, causality remains unknown. Thus, this study aimed to investigate causal relationships of high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), total (TC), triglyceride (TG) on five types aneurysms, using genetic variants associated with four traits as instrumental variables a Mendelian randomization (MR) analysis.We performed two-sample analyses evaluate HDL-C,...
Objective ALPK3 is associated with a recessive form of pediatric cardiomyopathy accompanied by musculoskeletal and craniofacial abnormalities. Heterozygous truncating variants in this gene ( tv) have recently been confirmed as cause autosomal dominant hypertrophic (HCM). Whether also implicated HCM East Asia the effect missense on remains unresolved. Methods We compared frequency rare deleterious study cohort comprised 793 cases Asian descent to that controls subset Genome Aggregation...
Triple-negative breast cancer (TNBC) is a highly aggressive with poor prognosis. The lack of effective targeted therapies for TNBC remains profound clinical challenge. Fusion transcripts play critical roles in carcinogenesis and serve as valuable diagnostic therapeutic targets cancer. present study aimed to identify novel fusion TNBC. We analyzed the RNA sequencing data 360 samples filter candidates through SOAPfuse ChimeraScan analysis. characteristics, including recurrence, type,...
Abstract Background Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) is the most sensitive technique for evaluating gene expression levels. Choosing appropriate reference genes (RGs) critical normalizing and changes in of target genes. However, uniform reliable RGs breast cancer research have not been identified, limiting value studies. Here, we aimed to identify accurate tissues cell lines using RNA-seq dataset. Methods First, compiled transcriptome profiling data from...
The prognosis of heart failure (HF) depends on genetic predisposition, and recent studies have shown that impaired autophagy is involved in HF. This study was aimed to construct a prognostic model combining polygenetic background based the pathway other traditional risk factors (TRF) HF prognosis.Via re-analysing transcriptomic data 50 failing 14 non-failing donors, differentially expressed autophagy-related genes (ARGs) were chosen for further comparison analysis with whole exome sequencing...
Carnitine has been associated with cardiac energy metabolism and heart failure, but the association between its precursors-trimethyllysine (TML) γ-butyrobetaine (GBB)-and failure preserved ejection fraction (HFpEF) remains unclear.To evaluate relationship TML-related metabolites HFpEF in an Asian population.The cross-sectional component of this study examined plasma HFpEF, while a prospective cohort design was applied to examine incident cardiovascular events HFpEF. Included were 1000...
Brugada syndrome (BrS) is an inheritable arrhythmia that can lead to sudden cardiac death in patients while the heart structure normal. However, genetic background of more than 65% BrS probands remains unclear.The purpose this study report variant spectrum a Chinese cohort with suspected and analyze their distinct clinical electrocardiographic features.Patients from Tongji Hospital between 2008 2021 were analyzed retrospectively.A total 79 included study. Patients type 1 electrocardiogram...
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Objective To explore the efficacy and safety of target-conteolled infusion ( TCI ) propofol by laryngeal mask airway LMA in gynecologic laparoseopic surgery.Methods 60 ASA Ⅰ - Ⅱ patients aged 18 to 45 scheduled for surgery were randomly divided into two group.Group A received anesthesia with group B general tracheal intubation combined intravenous propofol.Changes MAP HR monitored at pre-induction,3 min after induction,the moment or wearing mask,5 mask,the removal tube mask,and 5 groups.The...
Objective To study the clinical effect of different ways heat preservation in patients during operation with general anesthesia.Methods 120 scheduled for surgery under anesthesia were randomly divided into control group and experiment group,with 60 each group.The just used air heating,the combined heating fluid heating.Patients' temperature recorded at entering operating room(OR) getting out it.Results The temperatures all normal.None was below 36℃.No experienced complications...