A5030896863- Viral Infections and Immunology Research
- Helminth infection and control
- interferon and immune responses
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Connective tissue disorders research
- Systemic Lupus Erythematosus Research
- Cardiovascular Effects of Exercise
- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Cardiac Fibrosis and Remodeling
- Galectins and Cancer Biology
Tongji Hospital
2021-2025
Huazhong University of Science and Technology
2021-2025
Abstract Background and Purpose Myocarditis is a life‐threatening inflammatory disease, but lacks effective treatment options. Hydroxychloroquine (HCQ), an established antimalarial agent, used widely to manage rheumatic disorders. This research aimed evaluate the efficacy of HCQ in treating myocarditis. Experimental Approach A mouse model experimental autoimmune myocarditis (EAM) was therapeutic effects on cardiac function, inflammation fibrosis. Echocardiography, histology cytokine assays...
Although the associations between serum lipid levels and aneurysms have been investigated in epidemiological studies, causality remains unknown. Thus, this study aimed to investigate causal relationships of high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), total (TC), triglyceride (TG) on five types aneurysms, using genetic variants associated with four traits as instrumental variables a Mendelian randomization (MR) analysis.We performed two-sample analyses evaluate HDL-C,...
Background: Myocarditis is a live-threatening inflammatory disease of the heart and lack effective treatment measures. Hydroxychloroquine (HCQ), classic antimalarial drug, has been widely used in rheumatic diseases. This study investigated whether HCQ can treat chronic autoimmune myocarditis. Methods Results: Murine myocarditis was induced, therapeutic effects oral on acute were evaluated using echocardiography, cardiac catheterization, analysis scores tissue. Results showed that...