A5101755821- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
- Trypanosoma species research and implications
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- ATP Synthase and ATPases Research
- Educational Robotics and Engineering
- Robotic Path Planning Algorithms
- Cardiac Fibrosis and Remodeling
- Aortic Disease and Treatment Approaches
- Respiratory viral infections research
- Ion Channels and Receptors
- Robotics and Sensor-Based Localization
- Signaling Pathways in Disease
- Electromagnetic Fields and Biological Effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Glycation End Products research
- Genomics and Rare Diseases
- PI3K/AKT/mTOR signaling in cancer
- Connective tissue disorders research
- Protein Kinase Regulation and GTPase Signaling
- Peroxisome Proliferator-Activated Receptors
Huazhong University of Science and Technology
2017-2024
Central Hospital of Wuhan
2022-2024
Tongji Hospital
2017-2022
Weatherford College
2022
Northeastern University
2018
Nanjing University of Chinese Medicine
2015
Genome-wide association studies (GWAS) have identified abundant risk loci associated with schizophrenia (SCZ), cardiovascular disease and metabolic diseases (including body mass index, type 2 diabetes, low- high-density lipoprotein, total cholesterol triglycerides). Although recent suggested shared genetic between these disorders, the common genes biological pathways them are still vague. Here we integrated comprehensive multi-dimensional data from GWAS, expression quantitative trait (eQTL)...
Cardiac sialylation is involved in a variety of physiological processes the heart. Altered has been implicated heart failure (HF) mice. However, its role patients with HF unclear, and potential effect modulation cardiac worth exploring. We first assessed association between plasma N-acetylneuraminic acid levels incidence adverse cardiovascular events over median follow-up period 2 years. Next, immunoblot analysis lectin histochemistry were performed tissue to determine expression...
Abstract Receptor‐interacting protein kinase 3 (RIP3) is a key determinant of necroptosis and participates in ischaemia—and oxidative stress‐induced necroptosis, myocardial remodelling heart failure (HF). In this study, we tested the hypothesis that common variants RIP3 gene were associated with risk prognosis HF Chinese Han population. By re‐sequencing luciferase assays, identified functional variant promoter region. The rs3212247‐T allele suppressed activity by facilitating transcription...
Long noncoding RNAs (lncRNAs) are currently considered to have a vital and wide range of biological functions, but the molecular mechanism underlying triglycerides metabolism remains poorly understood. This study aims identify novel lncRNAs differentially expressed in rat livers with hypertriglyceridemia elucidated function role TG metabolism. Differentially expressions were identified by transcriptome sequencing validated real-time PCR. The lnc19959.2 triglyceride was assessed both vitro...
The effects of exposure to magnetic fields (MFs) at electric frequencies (50-60 Hz) on carcinogenicity are still in debate. Whether MFs affects the heart is also a debated issue. This study aimed determine whether extremely low frequency (ELF-MFs) induced DNA damage cardiomyocytes both vitro and vivo Human ventricular were exposed 50 Hz ELF-MF 100 µT for 1 h continuously or 75 min intermittently. treatments evaluated by damage, redox status changes relative signal molecular expression....
Chronic heart failure (CHF) has poor prognosis and polygenic heritability, the genetic risk score (GRS) to predict CHF outcome not yet been researched comprehensively. In this study, we sought establish GRS outcomes of CHF. We re-analysed proteomics data failing human combined them filter high-throughput sequencing in 1000 Chinese cohort. Cox hazards models were used based on single nucleotide polymorphisms (SNPs) estimate association with CHF, analyse difference between individual SNPs...
Background: Common variants may contribute to the variation of prognosis heart failure (HF) among individual patients, but no systematical analysis was conducted using transcriptomic and whole exome sequencing (WES) data. We aimed construct a genetic risk score (GRS) estimate its potential as predictive tool for HF-related mortality alone in combination with traditional factors (TRFs). Methods Results: reanalyzed data 177 failing hearts 136 healthy donors. Differentially expressed genes...
Abstract Aims The aim of this study was to investigate the effects Neuraminidase inhibitors (NI) on COVID-19 in a retrospective study. Methods and results included an overall patients (n = 3267) 1:1 propensity score-matched 972). levels plasma N-acetylneuraminic acid neuraminidase expression were further evaluated panel hospitalized 1-month post-infection recovered subjects. mortality rate 9.6% (313/3267) 9.2% (89/972) propensity-score matched patients. NI treatment lowered (5.7% vs. 10.3%)...
Abstract Aims Our objective was to investigate the association of common variants in coding region advanced glycosylation end‐product specific receptor (RAGE) and prognosis heart failure (HF). Methods results A total 3394 HF patients were continuously enrolled from January 2009 August 2018 with a median follow‐up 20.4 months. Additionally, 2861 healthy subjects also participated study. By sequencing these two groups, we identified functional missense variant rs2070600 RAGE, which showed...
The prognosis of heart failure (HF) depends on genetic predisposition, and recent studies have shown that impaired autophagy is involved in HF. This study was aimed to construct a prognostic model combining polygenetic background based the pathway other traditional risk factors (TRF) HF prognosis.Via re-analysing transcriptomic data 50 failing 14 non-failing donors, differentially expressed autophagy-related genes (ARGs) were chosen for further comparison analysis with whole exome sequencing...
Abstract The carbohydrate response element‐binding protein (Ch REBP ), also referred to as MLXIPL , plays a crucial role in the regulation of glucose and lipid metabolism. Existing studies have shown an association between genetic variations Ch gene levels, such triglycerides high‐density lipoprotein cholesterol. However, mechanistic this are limited. In study, bioinformatic analysis revealed that polymorphism rs1051943A occurs complementary binding sequence miR‐1322 3′‐untranslated region (...
Abstract Phosphoinositide 3‐kinase γ (PI3Kγ) is G‐protein‐coupled receptor‐activated lipid kinase with both kinase‐dependent and kinase‐independent activity. Plenty of evidence have demonstrated that PI3Kγ participated in TAC I/R‐induced myocardial remodelling heart failure (HF). In this study, we tested the hypothesis common variants gene ( PIK3CG ) were associated prognosis HF Chinese Han population. Through re‐sequencing genotyping, finally identified a variant 3′UTR strongly two‐stage...
Background: Genetic variants in Scavenger receptor Class B Type 1 (SCARB1) influencing high-density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD) risk were identified by recent genome-wide association studies. Further study of potential functional SCARB1 may provide new ideas the complicated relationship between HDL-C CHD. Methods: 2000 bp promoter region was re-sequenced 168 participants with extremely high plasma 400 control subjects. Putative alleles using...
Aiming at the problem of robot motion planning under environment obstacles, this paper studies obstacle avoidance method arm ROS platform (Robot Operating System). Based on service developed by team, URDF (Unified Robot Description Format) file is exported from 3-D SolidWorks model using SW2URDF plugin, and configuration launch files needed for are created MoveIt! Setup Assistant. By relevant APIs provided invoking random sampling based algorithm RRT we completed planning, object grasping...
A Human-friendly control method is proposed to solve the problem that traditional inverse kinematics of motion chain difficult be solved by coupling chest when waist as starting double arm chain. The inertial capture module collects operator's and establishes relative rotation matrix between modules. joint angle manipulator calculated corresponding relation robot matrix. master-slave experiment was carried out using solid-arm humanoid robot. operator platform completes interactive action...
<b><i>Introduction:</i></b> The role of neuraminidases in cardiovascular disease has recently gained increasing attention. However, the association between neuraminidase gene polymorphisms and heart failure (HF) not yet been investigated. <b><i>Methods Results:</i></b> Genotyping nine single-nucleotide (SNPs) NEU2/NEU3/NEU4 genes was performed 610 HF patients 600 healthy controls from Southwest Han Chinese population using TaqMan SNP Assay....
The purpose was to identify the Transient receptor potential (TRP) superfamily gene variants associate with prognosis of ischemic cardiomyopathy (ICM). A whole-exome sequencing study involving 252 ICM and healthy controls participants enrolled from March 2003 November 2017. Optimal sequence kernel association test Cox regression dominant conducted cause genes TRP common SNPs ICM. Rs224534 verified in replication population. Besides, expression TRPV1 detectable human failed heart ventricular...