A5041272224- Pulmonary Hypertension Research and Treatments
- Vehicle emissions and performance
- Extracellular vesicles in disease
- Protease and Inhibitor Mechanisms
- Advanced Decision-Making Techniques
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Traffic Prediction and Management Techniques
- Metabolism and Genetic Disorders
- Simulation and Modeling Applications
- Endoplasmic Reticulum Stress and Disease
- Bladder and Urothelial Cancer Treatments
- Botanical Research and Applications
- Nanoplatforms for cancer theranostics
- Muscle activation and electromyography studies
- Urinary and Genital Oncology Studies
- Autonomous Vehicle Technology and Safety
- Galectins and Cancer Biology
- Energy, Environment, and Transportation Policies
- Natural Antidiabetic Agents Studies
- Infectious Aortic and Vascular Conditions
- Acute Ischemic Stroke Management
- Aviation Industry Analysis and Trends
North China Municipal Engineering Design & Research Institute
2023-2024
Capital Medical University
2024
Boston Children's Hospital
2024
Harvard University
2024
East China University of Political Science and Law
2024
Beijing Institute of Neurosurgery
2024
Peking University
2018-2023
Institute of Mountain Hazards and Environment
2022
Chinese Academy of Sciences
2022
Harbin Medical University
2022
Objective— We aimed to assess whether exposure higher levels of ambient air pollution impairs HDL (high-density lipoprotein) function and elucidate the underlying biological mechanisms potentially involved. Approach Results— In Beijing AIRCHD study (Air Pollution Cardiovascular Dysfunction in Healthy Adults), 73 healthy adults (23.3±5.4 years) were followed-up with 4 repeated visits 2014 2016. During each visit, concentrations, metrics, parameters inflammation oxidative stress measured....
Abstract Vulnerable atherosclerotic (AS) plaque is the major cause of cardiovascular death. However, clinical methods cannot directly identify vulnerable AS at molecule level. Herein, osteopontin antibody (OPN Ab) and NIR fluorescence molecules ICG co‐assembled Ti 3 C 2 nanosheets are reported as an advanced nanoprobe Ab/Ti /ICG) with enhanced photoacoustic (PA) performance for direct non‐invasive in vivo visual imaging plaque. The designed OPN /ICG nanoprobes successfully realize obvious...
Abstract Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through production gut-derived metabolites. However, specific metabolites and their pathophysiological contribution cardiac hypertrophy or heart failure progression still remain unclear. N,N,N-trimethyl-5-aminovaleric acid (TMAVA), derived from trimethyllysine gut microbiota, was elevated with gradually increased risk mortality transplantation in a prospective...
Abstract Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant phenotypic alterations in smooth muscle cells (VSMCs). Gasdermin D (GSDMD) pore‐forming effector of pyroptosis. In this study, the role VSMC‐specific GSDMD alteration VSMCs and AAA formation determined. Single‐cell transcriptome analyses reveal Gsdmd upregulation angiotensin (Ang) II‐induced AAA. deletion ameliorates Ang apolipoprotein E (ApoE) −/− mice. Using untargeted metabolomic analysis, it...
Abstract Aims Eva-1 homologue 1 (Eva1a) is a novel protein involved in the regulation of cardiac remodelling and plaque stability, but little known about its role re-endothelialization development atherosclerosis (AS). Thus, present study, we aimed to elucidate function Eva1a AS. Methods results Wire injuries carotid femoral arteries were established Eva1a−/− mice. Eva1a-deficient mice crossed with apolipoprotein E−/− (ApoE−/−) evaluate AS artery injuries. Denudation at 3, 5, 7 days was...
Cardiac sialylation is involved in a variety of physiological processes the heart. Altered has been implicated heart failure (HF) mice. However, its role patients with HF unclear, and potential effect modulation cardiac worth exploring. We first assessed association between plasma N-acetylneuraminic acid levels incidence adverse cardiovascular events over median follow-up period 2 years. Next, immunoblot analysis lectin histochemistry were performed tissue to determine expression...
We aimed to examine the hypothesis that circulating trimethylamine-N-oxide (TMAO) levels serve as a biomarker in pulmonary arterial hypertension (PAH), and determine whether 3,3-dimethyl-1-butanol (DMB), TMAO inhibitor, exerted protective effect monocrotaline (MCT)-induced PAH rats.In-patients with were prospectively recruited from Fuwai Hospital. Fasting blood samples obtained assess other laboratory values during initial second hospitalization. In MCT-induced rat, normal diet water...
Low density cholesterol receptor (LDLR) in the liver is critical for clearance of low-density lipoprotein (LDL-C) blood. In atherogenic conditions, proprotein convertase subtilisin/kexin 9 (PCSK9) secreted by liver, a nonenzymatic fashion, binds to LDLR on surface hepatocytes, preventing its recycling and enhancing degradation lysosomes, resulting reduced LDL-C clearance. Our recent studies demonstrate that epsins, family ubiquitin-binding endocytic adaptors, are regulators atherogenicity....
Macrophages regulate the inflammatory response and affect re-endothelialization. Inflammation macrophages play important roles in promoting tissue repair, but p38α mitogen-activated protein kinase's role re-endothelialization is unknown. Wire injuries of carotid arteries Evans blue staining were performed macrophage-specific p38α-knockout (p38αfl/flLysMCre+/-) mice control (p38αfl/fl). Re-endothelialization at 3, 5 7 days was significantly promoted p38αfl/flLysMCre+/- mice. In vitro...
Background Trimethyllysine, a trimethylamine N‐oxide precursor, has been identified as an independent cardiovascular risk factor in acute coronary syndrome. However, limited data are available to examine the role of trimethyllysine population with stroke. We aimed relationship between plasma levels and stroke outcomes patients presenting ischemic or transient attack. Methods Results Data 10 027 stroke/transient attack from CNSR‐III (Third China National Stroke Registry) 1‐year follow‐up for...
Background and Objective The association between plasma betaine levels cardiovascular diseases (CVDs) has been revealed except for pulmonary hypertension (PH). In this study, we aimed to explore the role of in patients with PH. Methods Inpatients PH at Fuwai Hospital were enrolled after excluding relative comorbidities. Each patient received least one follow-up through a clinical visit, fasting blood was obtained both first second hospitalization detection. primary endpoint defined as...
At present, the mixed conditions at road intersections are more prominent, pedestrians crossing street and vehicles turning often collide, which has a great impact on safety of pedestrians. Although pedestrian alarm system car played very good role in improving traffic safety, due to high false rate this method, driver lacks way deal with it. Therefore, order solve problem accurate prediction intention improve crossing, paper takes urban unsignalized as an example, analyzes influencing...
Abstract The bioremediation of heavy metals contaminated soils with macrofungi is a new and promising approach; hence Agaricus bisporus (Large) sing has potentially shown accumulating ability to Cd contamination. This study focused on the tolerance response by A. different contents in closed cup flat stage fruiting body development. Cd, soluble protein, sugar, low molecular weight organic acids (LMWOAs), antioxidant activity were investigated. bioaccumulation factor transfer results revealed...
Achilles tendon rupture (ATR) can lead to significant disability of patients. However, whether serum lipid levels are associated with ATR is still unclear. This study aimed examine the difference in between patients and those without ATR.Patients who received surgery during January 2017 December were categorized into case group, had physical examinations same period control group. Different matching methods [case-control (CCM) propensity score (PSM)] used match cases controls at a 1:1...
Objective The study objective was to investigate the prognostic risk factors related overall survival (OS), cancer-specific (CSS), recurrence-free (RFS), and metastasis-free (MFS) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Patients were then divided into different groups (based on their number of factors), specific postoperative treatment plans formulated patients in groups. Methods We retrospectively analyzed data 401 with UTUC who underwent RNU...
Carnitine has been associated with cardiac energy metabolism and heart failure, but the association between its precursors-trimethyllysine (TML) γ-butyrobetaine (GBB)-and failure preserved ejection fraction (HFpEF) remains unclear.To evaluate relationship TML-related metabolites HFpEF in an Asian population.The cross-sectional component of this study examined plasma HFpEF, while a prospective cohort design was applied to examine incident cardiovascular events HFpEF. Included were 1000...
Existing intersection safety evaluation methods are mostly based on traffic accident data statistics, which has shortcomings such as difficulty in acquisition, long collection time and span. In order to solve these problems, this study obtains high-definition accurate spatio-temporal trajectory of different subjects at intersections through UAV detection technology, combines the conflict theory. Three indexes were obtained, five Tianjin evaluated by using grey clustering method, divided into...
The layout of urban charging stations is unreasonable, and it difficult to charge green energy vehicles. Based on the above problems, equalization, accessibility, allocation construction rate Tianjin Automobile Charging Station are studied. Firstly, hot data important places, parking lots obtained in through Gaode API, then ArcGIS kernel density analysis, buffer analysis other methods used study. study found that automobile relatively balanced, core area has achieved full coverage stations....