A5101539771- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Ureteral procedures and complications
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Immunotherapy and Immune Responses
- Cholesterol and Lipid Metabolism
- Phagocytosis and Immune Regulation
- MXene and MAX Phase Materials
- T-cell and B-cell Immunology
- Sphingolipid Metabolism and Signaling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
Third Affiliated Hospital of Harbin Medical University
2016-2025
Harbin Medical University
2013-2025
First Affiliated Hospital of Harbin Medical University
2017
Second Affiliated Hospital of Nanjing Medical University
2016
Long noncoding RNAs (lncRNAs) have emerged as important molecules and potential new targets for human cancers. This study investigates the function of lncRNA CTBP1 antisense RNA (CTBP1-AS) in prostate cancer (PCa) explores entailed molecular mechanism. Aberrantly expressed genes potentially correlated with PCa progression were probed using integrated bioinformatics analyses. A cohort 68 patients was included, their tumor para-cancerous tissues collected. CTBP1-AS highly cells associated poor...
Aim Previous research has shown a strong association between insulin resistance (IR) and both the onset advancement of diabetic kidney disease (DKD). This focuses on examining relationship IR all-cause mortality in individuals with DKD. Methods study utilized data obtained from National Health Nutrition Examination Survey (NHANES), spanning years 2001 to 2018. Insulin was assessed using reliable indicators (HOMA-IR, TyG, TyG-BMI, METS-IR). The indices survival outcomes evaluated through...
Aims: To investigate the effects of neutral ceramidase (NCDase) packaged in exosomes that are secreted from β-cells on free fatty acid (FFA)-induced apoptosis and its role regulation sphingolipid-mediated signaling pathway. Methods: HPLC Western blotting were performed to determine NCDase activity expression. Annexin V-fluorescein-isothiocyanate/propidium iodide flow cytometry was used assess apoptosis. Electrospray ionization tandem mass spectrometry for ceramide (Cer),...
Clear-cell renal cell carcinoma (ccRCC) is an aggressive and malignant kidney cancer which has the worst prognosis. Although microRNAs (miRNAs) have recently been identified as a novel class of regulators in oncogenesis metastasis, there are few studies on their participation ccRCC. In present study, we observed that miR-367 expression was increased both human ccRCC tissues lines. Cell proliferation evaluated by MTT assay 5-Ethynyl-2'-deoxyuridine (EdU) kit, indicated inhibition could...
We aimed to discover the potential microRNA (miRNA) targets and explore underlying molecular mechanisms of clear cell renal carcinoma (ccRCC).Microarray data GSE16441 was downloaded from Gene Expression Omnibus database. Differentially expressed genes (DEGs) differentially miRNAs between ccRCC tumors matched non-tumor samples were analyzed. Target screened. Besides, functional enrichment analysis DEGs performed, followed by protein-protein interaction (PPI) network construction sub-module...
To identify the N6-methyladenosine (m6A) methylation regulator genes linking prostate adenocarcinoma (PRAD) and periodontitis (PD).PD TCGA-PRAD GEO datasets were downloaded analyzed through differential expression analysis to determine differentially expressed (DEGs) deregulated in both conditions. Twenty-three m6A RNA methylation-related total. The m6A-related that overlapped between PRAD PD identified as crosstalk genes. Survival was performed on these their prognostic values overall...
Objective The study objective was to investigate the prognostic risk factors related overall survival (OS), cancer-specific (CSS), recurrence-free (RFS), and metastasis-free (MFS) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Patients were then divided into different groups (based on their number of factors), specific postoperative treatment plans formulated patients in groups. Methods We retrospectively analyzed data 401 with UTUC who underwent RNU...
Abstract Purpose : Metastatic recurrence takes place in more than 21.7% of patients with UTUC underwent RNU. Although metastatic suggested a poor prognosis, the effect specific site on prognosis is still to be discussed. Methods: According retrospective analysis 355 who RNU for high-grade, node-negative upper urothelial carcinoma our hospital from 2010 2020. The result showed that no one received neoadjuvant or adjuvant chemotherapy. So, Univariate and multivariate Cox regression analyses...