A5100438241- Advanced Sensor and Energy Harvesting Materials
- Tactile and Sensory Interactions
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Soft Robotics and Applications
- Parasitic infections in humans and animals
- Lung Cancer Treatments and Mutations
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Dementia and Cognitive Impairment Research
- Teleoperation and Haptic Systems
- Retinal and Macular Surgery
- Algal biology and biofuel production
- Electrocatalysts for Energy Conversion
- Reproductive Biology and Fertility
- Congenital Anomalies and Fetal Surgery
- Sperm and Testicular Function
- Circadian rhythm and melatonin
- Gas Sensing Nanomaterials and Sensors
- Vascular Malformations Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Immune cells in cancer
- Retinal Diseases and Treatments
- Photosynthetic Processes and Mechanisms
Henan Provincial People's Hospital
2019-2025
Zhengzhou University
2017-2025
Nankai University
2023-2025
Central South University
2023-2025
Shihezi University
2024-2025
Xiangya Hospital Central South University
2023-2025
South China Botanical Garden
2025
University of Science and Technology of China
2016-2025
First Affiliated Hospital of Henan University of Science and Technology
2025
Hefei Infectious Disease Hospital
2021-2025
Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy...
With the rapid development of intelligent wearable electronic devices, highly compressible porous piezoresistive sensors are in imperative demand. However, robustness conductive coating that affects stability and durability still needs to be solved urgently. In this work, a flexible MXene/PEDOT:PSS@Melamine foam (MPMF) sensor was designed prepared by simply dip-coating it MXene PEDOT:PSS mixed solution. Here, skeleton first treated with PDA improve its hydrophilicity enhance interfacial...
With the rapid development of wearable electronics, a multifunctional and flexible strain sensor is urgently required. Even though enormous progress has been achieved in designing high-performance sensors, conflict between high sensitivity large workable range still restricts their further advance. Herein, "point to point" conductive network proposed design fabricate carbon black/polyaniline nanoparticles/thermoplastic polyurethane film (CPUF). The designed structure renders CPUF composites...
Extracellular matrix (ECM) is crucial in various biological functions during tumor progression, including induction of anoikis resistance and cell adhesion-mediated drug (CAM-DR). Fibronectin (FN) a vital ECM component with direct regulatory effects on ECM-mediated CAM-DR, making it an attractive innovative therapeutic target for depriving tissue. Herein, deprivation system (EDS) developed based FN targeting self-assembly peptide constructing nanofibers the renal carcinoma (RCC), which...
PURPOSE This phase 3 trial aimed to compare the efficacy and safety of capecitabine or plus oxaliplatin (XELOX) with those fluorouracil cisplatin (PF) in definitive concurrent chemoradiotherapy (DCRT) for inoperable locally advanced esophageal squamous cell carcinoma (ESCC). METHODS Patients were randomly assigned receive two cycles capecitabine, XELOX, PF along intensity-modulated radiation therapy. each arm again consolidation chemotherapy not. The primary end points 2-year overall...
This paper presents CofiFab, a coarse-to-fine 3D fabrication solution, combining printing and 2D laser cutting for cost-effective of large objects at lower cost higher speed. Our key approach is to first build coarse internal base structures within the given object using cutting, then attach thin 3D-printed parts, as an external shell, onto recover fine surface details. CofiFab achieves this with three novel algorithmic components. First, we formulate optimization model compute fabricatable...
Force feedback gloves are promising for producing immersive haptic sensations in virtual reality systems or intuitive control of remote robots dexterous manipulation tasks. Existing mainly adopt rigid actuators. In this article, we propose a force glove using pneumatically powered fiber-reinforced soft bending Based on the unilateral deformable feature actuator, dorsal-side mounted soft-rigid linkage mechanism is proposed to produce fingertip feedback. We incorporated and experimentally...
Abstract Background A retrospective analysis verified the role of gene mutations in brain metastasis patients with non‐small cell lung cancer (NSCLC). Methods Data from 552 advanced NSCLC treated January 2015 to June 2017 Affiliated Cancer Hospital Zhengzhou University were retrospectively analyzed. Next‐generation sequencing was used detect eight reported driver genes and various risk factors evaluated. Results Of NSCLC, 153 (27.7%) had metastases. The univariate showed that age ( P =...
Bladder cancer displays multiple biological features aided in drug resistance; therefore, single therapy fails to induce complete tumor regression. To address this issue, various kinds of cell death cells as well restoring immune microenvironment need be taken into consideration. Here, we introduce a gel system termed AuNRs&IONs@Gel, which target-delivers combination photothermal, ferroptotic, and through intravesical instillation. AuNRs&IONs@Gel consists delivery platform, embedded gold...
Abstract Critical-sized bone defects caused by traumatic fractures, tumour resection and congenital malformation are unlikely to heal spontaneously. Bone tissue engineering is a promising strategy aimed at developing in vitro replacements for transplantation overcoming the limitations of natural grafts. In this study, we developed an innovative scaffold based on gelatin methacrylate (GelMA) hydrogel, obtained via two-step procedure: first, solid lipid nanoparticles (SLNs) were loaded with...
The acrosome is a membranous organelle positioned in the anterior portion of sperm head and essential for male fertility. Acrosome biogenesis requires dynamic cytoskeletal shuttling vesicles toward nascent which regulated by series accessory proteins. However, much remains unknown about molecular basis underlying this process. Here, we generated Ssh2 knockout (KO) mice HA-tagged knock-in (KI) to define functions Slingshot phosphatase 2 (SSH2) spermatogenesis demonstrated that as regulator...
A vital bioactive component of marine resources is Holothuria leucospilota polysaccharides (HLP). This study examined whether HLP could regulate intestinal flora to treat loperamide-induced constipation. Constipated mice showed signs prolonged defecation (up by 60.79 min) and a reduced number bowel movements pellet water content (decreased 12.375 11.77%, respectively). The results that treatment these symptoms, reversed the changes in related protein expression levels colon, regulated active...
ABSTRACT Mitochondriopathy inspired adenosine triphosphate (ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains prodigious challenge. Harnessing the advantages in vivo self-assembled nanomaterials, we designed an Intracellular Sequestration (IAS) system to specifically construct nanofibrous nanostructures on surface nuclei with exposed binding sites,...
We study assemblies of convex rigid blocks regularly arranged to approximate a given freeform surface. Our designs rely solely on the geometric arrangement form stable assembly, neither requiring explicit connectors or complex joints, nor relying friction between blocks. The convexity simplifies fabrication, as they can be easily cut from different materials such stone, wood, foam. However, designing is challenging, since adjacent pairs are restricted in their relative motion only direction...
China has implemented the "tiered medical services" policy since 2015, while there is a paucity of data evaluating current status chronic obstructive pulmonary disease (COPD) management under system. Characteristics and treatments from 11,905 COPD patients in 88 hospitals across different tiers were included analyzed. We assessed statistical significance differences by one way analysis variance (ANOVA) for continuous variables with chi-squared test categorical variables. Patients primary...