A5031697750- Tree-ring climate responses
- Plant Water Relations and Carbon Dynamics
- Geology and Paleoclimatology Research
- Climate variability and models
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Plant Stress Responses and Tolerance
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Photosynthetic Processes and Mechanisms
- Plant Virus Research Studies
- Plant-Microbe Interactions and Immunity
- Advanced Nanomaterials in Catalysis
- Hydrology and Watershed Management Studies
- Protein Degradation and Inhibitors
- Gout, Hyperuricemia, Uric Acid
- Ubiquitin and proteasome pathways
- Hydrology and Drought Analysis
- Plant nutrient uptake and metabolism
- Radiomics and Machine Learning in Medical Imaging
- Plant Molecular Biology Research
- Plant Pathogens and Resistance
- Isotope Analysis in Ecology
- Air Quality Monitoring and Forecasting
- Gastric Cancer Management and Outcomes
Xi'an Jiaotong University
2023-2025
Emory University
2025
Institute of Geology and Geophysics
2016-2024
Chinese Academy of Sciences
2015-2024
Guangdong University of Technology
2014-2024
Shanghai Normal University
2015-2024
Xiamen University
2021-2024
Arizona State University
2020-2024
Insilico Medicine (United States)
2024
Insilicos (United States)
2024
Abstract Reproducible climate reconstructions of the Common Era (1 CE to present) are key placing industrial-era warming into context natural climatic variability. Here we present a community-sourced database temperature-sensitive proxy records from PAGES2k initiative. The gathers 692 648 locations, including all continental regions and major ocean basins. trees, ice, sediment, corals, speleothems, documentary evidence, other archives. They range in length 50 2000 years, with median 547...
Spinach is an important leafy vegetable enriched with multiple necessary nutrients. Here we report the draft genome sequence of spinach (Spinacia oleracea, 2n=12), which contains 25,495 protein-coding genes. The highly repetitive 74.4% its content in form transposable elements. No recent whole duplication events are observed spinach. Genome syntenic analysis between and sugar beet suggests substantial inter- intra-chromosome rearrangements during Caryophyllales evolution. Transcriptome...
Atherosclerotic vascular disease (ASVD) is the leading cause of death worldwide. Hyperuricemia fourth risk factor for atherosclerosis after hypertension, diabetes, and hyperlipidemia. The mechanism hyperuricemia affecting occurrence development has not been fully elucidated. Mononuclear macrophages play critical roles in all stages atherosclerosis. Studies have confirmed that both ferroptosis promote atherosclerosis, but whether high level uric acid (HUA) promotes by regulating remains...
Rice is a major staple food worldwide. Making hybrid rice has proved to be an effective strategy significantly increase grain yield. Current technologies rely on male sterile lines and have been used predominantly in indica cultivars. However, intrinsic problems exist the implementation of these technologies, such as limited germplasms unpredictable conversions from sterility fertility field. Here, we describe photoperiod-controlled line, carbon starved anther ( csa ), which contains...
We developed a 50‐year tree ring δ 18 O chronology for each of three species ( Juniperus indica , Larix griffithii and Picea spinulosa ) using total 12 trees (four per species) from the Bhutan Himalaya. Despite originating different sampled at two altitudes, chronologies are highly correlated with one another r = 0.76–0.89). Response analyses reveal that values controlled mainly by summer precipitation, irrespective species. Based on these results, robust 269‐year was established to...
Elevated temperatures limit plant growth and reproduction pose a growing threat to agriculture. Plant heat stress response is highly conserved fine-tuned in multiple pathways. Spinach (Spinacia oleracea L.) cold tolerant but sensitive green leafy vegetable. In this study, adaptation mechanisms spinach sibling inbred heat-tolerant line Sp75 were investigated using physiological, proteomic, phosphoproteomic approaches. The abundance patterns of 911 stress-responsive proteins, phosphorylation...
Abstract. We have constructed a regional tree-ring cellulose oxygen isotope (δ18O) record for the northern Indian sub-continent based on two new records from India and central Nepal three published northwestern India, western Bhutan. The spans common interval 1743 to 2008 CE. Correlation analysis reveals that is significantly negatively correlated with climatic indices: all rainfall (AIR; r = −0.5, p < 0.001, n 138), monsoon index (IMI; −0.45, 51) intensity of monsoonal circulation (r...
Abstract Spinach is a nutritious leafy vegetable belonging to the family Chenopodiaceae. Here we report high-quality chromosome-scale reference genome assembly of spinach and resequencing 305 cultivated wild accessions. Reconstruction ancestral Chenopodiaceae karyotype indicates substantial rearrangements in after its divergence from Chenopodiaceae, coinciding with high repeat content genome. Population genomic analyses provide insights into genetic diversity population differentiation....
Doxorubicin (DOX) is a most common anthracycline chemotherapeutic agent; however, its clinical efficacy limited due to severe and irreversible cardiotoxicity. Ferroptosis, characterized by iron overload lipid peroxidation, plays pivotal role in DOX-induced Resveratrol (RSV) displays cardioprotective anticancer effects, owing antioxidative anti-inflammatory properties. However, the mechanism of RSV DOX-mediated ferroptosis cardiomyocytes unclear. This study showed that DOX decreased cell...
Overexpression of nuclear receptor binding SET domain protein 2 (NSD2) is frequent in multiple myeloma (MM). However, existing NSD2 inhibitors are largely ineffective suppressing MM cell proliferation. Here, we report the discovery a first-in-class proteolysis targeting chimera (PROTAC) degrader, 9 (MS159), and two structurally similar controls, 17 (MS159N1) 18 (MS159N2), with diminished to cereblon (CRBN) E3 ligase NSD2, respectively. Compound 9, but not 18, effectively degraded...
Nuclear receptor-binding SET domain-containing 2 (NSD2) plays important roles in gene regulation, largely through its ability to dimethylate lysine 36 of histone 3 (H3K36me2). Despite aberrant activity NSD2 reported numerous cancers, efforts selectively inhibit the catalytic this protein with small molecules have been unsuccessful date. Here, we report development UNC8153, a novel NSD2-targeted degrader that potently and reduces cellular levels both H3K36me2 chromatin mark. UNC8153 contains...
Trimethylation of histone H3 lysine 9 (H3K9me3) is crucial for the regulation gene repression and heterochromatin formation, cell-fate determination organismal development1. H3K9me3 also provides an essential mechanism silencing transposable elements1–4. However, previous studies have shown that canonical readers (for example, HP1 (refs. 5–9) MPP8 10–12)) limited roles in endogenous retroviruses (ERVs), one main element classes mammalian genome13. Here we report...
Hypoxia-inducible factor prolyl hydroxylase (PHD) inhibitors have been approved for treating renal anemia yet failed clinical testing inflammatory bowel disease because of a lack efficacy. Here we used multimodel multimodal generative artificial intelligence platform to design an orally gut-restricted selective PHD1 and PHD2 inhibitor that exhibits favorable safety pharmacokinetic profiles in preclinical studies. ISM012-042 restores intestinal barrier function alleviates gut inflammation...
Abstract The catalytic activity of carbon dots (CDs) has generated significant interest regarding their potential applications within the biomedical field. However, structure‐activity relationship CDs and pharmacological mechanisms in disease treatment have yet to be comprehensively elucidated. In this study, two distinct types exhibiting superoxide dismutase (SOD)‐like enzymatic activities are synthesized through hydrothermal (Hy‐CDs) carbonization (Ca‐CDs) methods, utilizing Honeysuckle as...
[1] A tree ring cellulose δ18O chronology of Fokienia hodginsii from 1951 to 2002 is established by four cores different trees explore its potential for reconstructing climatic variations in northern Laos. This the first Laos as well this species. We compare and width between cores. The results suggest that time series are more strongly correlated than are. In addition, correlation analysis shows a significantly negative May–October Palmer Drought Severity Index (PDSI), while indices have...
A tree ring δ 18 O chronology is developed for the past 300 years (1705–2004) using 6 cypress trees from northern Vietnam to reconstruct long‐term hydroclimatic variations in summer monsoon season. To best of our knowledge, this first well‐replicated Southeast Asia, as well longest yet produced. Response analyses reveal that significantly correlated with temperature, precipitation, and Palmer Drought Severity Index (PDSI) during period May–October, highest correlation PDSI. Our accounts 44%...
The eukaryotic translation initiation factor 5A (eIF5A) promotes formation of the first peptide bond at onset protein synthesis. However, function eIF5A in plants is not well understood. In this study, we characterized (TaeIF5A1) from Tamarix androssowii. promoter TaeIF5A1 with 1,486 bp length was isolated, and cis-elements were identified. A WRKY (TaWRKY) RAV (TaRAV) can specifically bind to a W-box motif activate expression TaeIF5A1. Furthermore, TaeIF5A1, TaWRKY TaRAV share very similar...
Hypoxia-inducible factor (HIF)-1α and HIF-2α are the main regulators of cellular responses to hypoxia. Post-translational modifications HIF-1α 2α necessary modulate their functions. The methylation non-histone proteins by Set7, an SET domain-containing lysine methyltransferase, is a novel regulatory mechanism control cell protein function in response various stresses. In this study, we show that Set7 methylates at 32 K29; inhibits expression HIF-1α/2α targets impairing occupancy HIF-α on...
Abstract A tree ring cellulose oxygen isotope (δ 18 O) chronology for the period 1870–2011 was established using samples from four Fokienia hodginsii trees with aim of exploring potential to use δ O records reconstruct climatic variations in Fujian, a subtropical region southeast China. We believe that this is first area. Response analysis revealed significantly correlated precipitation between April and September, relative humidity August October, Palmer drought severity index October. Our...
ABSTRACT Tomato is a major vegetable crop that has tremendous popularity. However, viral disease still factor limiting tomato production. Here, we report the virome identified through sequencing small RNAs of 170 field-grown samples collected in China. A total 22 viruses were identified, including both well-documented and newly detected viruses. The community dominated by few species, they exhibit polymorphisms recombination genomes with cold spots hot spots. Most coinfected multiple...